1FLC | pdb_00001flc

X-RAY STRUCTURE OF THE HAEMAGGLUTININ-ESTERASE-FUSION GLYCOPROTEIN OF INFLUENZA C VIRUS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1flcc1	All beta proteins	Viral protein domain	Viral protein domain	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
C	d1flcc2	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
E	d1flce1	All beta proteins	Viral protein domain	Viral protein domain	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
E	d1flce2	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
A	d1flca1	All beta proteins	Viral protein domain	Viral protein domain	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
A	d1flca2	Alpha and beta proteins (a/b)	Flavodoxin-like	SGNH hydrolase	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
B	d1flcb_	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
D	d1flcd_	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)
F	d1flcf_	Coiled coil proteins	Stalk segment of viral fusion proteins	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	Influenza hemagglutinin (stalk)	(Influenza C virus (C/Johannesburg/1/66) ) [TaxId: 100673 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	SGNH hydrolase-like	8044118	3001315	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8041200	3001342	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SGNH hydrolase-like	8044118	3001315	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	SGNH hydrolase-like	8044118	3001315	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Influenza hemagglutinin domain-like	8041200	3001342	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	SGNH hydrolase-like	8044118	3001315	SCOP2B (2022-06-29)
A	SCOP2 Family	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1	8028821	4002512	SCOP2 (2022-06-29)
A	SCOP2 Family	Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1	8031740	4003705	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Influenza hemagglutinin domain-like	8041200	3001342	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SGNH hydrolase-like	8044118	3001315	SCOP2 (2022-06-29)
B	SCOP2 Family	Influenza hemagglutinin (stalk)	8027213	4003840	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Influenza hemagglutinin (stalk)	8039592	3001616	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8039592	3001616	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Influenza hemagglutinin (stalk)	8039592	3001616	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Hema_esterase_2nd	e1flcC1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hema_esterase_2nd	ECOD (1.6)
C	Hema_esterase_1st	e1flcC2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Hema_esterase_1st	ECOD (1.6)
E	Hema_esterase_2nd	e1flcE1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hema_esterase_2nd	ECOD (1.6)
E	Hema_esterase_1st	e1flcE2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Hema_esterase_1st	ECOD (1.6)
A	Hema_esterase_2nd	e1flcA1	A: beta sandwiches	X: jelly-roll	H: Viral protein domain (From Topology)	T: Viral protein domain	F: Hema_esterase_2nd	ECOD (1.6)
A	Hema_esterase_1st	e1flcA2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: SGNH hydrolase (From Topology)	T: SGNH hydrolase	F: Hema_esterase_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.20.70.20	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)
E	2.20.70.20	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)
A	2.20.70.20	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)
B	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
D	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)
F	3.90.20.10	Alpha Beta	Alpha-Beta Complex	Hemagglutinin Ectodomain	Chain B	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF02710	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein (Hema_HEFG)	Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein	-	Family
A, C, E	PF03996	Hemagglutinin esterase (Hema_esterase)	Hemagglutinin esterase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	HAEMAGGLUTININ-ESTERASE-FUSION GLYCOPROTEIN	hydrolase activity, acting on ester bonds short-chain carboxylesterase activity carboxylic ester hydrolase activity acetylesterase activity hydrolase activity sialate O-acetylesterase activity catalytic activity sialate 9-O-acetylesterase activity sialate 4-O-acetylesterase activity host cell surface binding binding host cell surface receptor binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host endocytosis involved in viral entry into host cell non-lytic viral release viral budding virion assembly exit from host cell viral budding from plasma membrane viral release from host cell	cellular anatomical structure membrane virion component virion membrane viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane
B, D, F	HAEMAGGLUTININ-ESTERASE-FUSION GLYCOPROTEIN	hydrolase activity, acting on ester bonds short-chain carboxylesterase activity carboxylic ester hydrolase activity acetylesterase activity hydrolase activity sialate O-acetylesterase activity catalytic activity sialate 9-O-acetylesterase activity sialate 4-O-acetylesterase activity host cell surface binding binding host cell surface receptor binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane cellular process cellular component organization or biogenesis virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host endocytosis involved in viral entry into host cell non-lytic viral release viral budding virion assembly exit from host cell viral budding from plasma membrane viral release from host cell	cellular anatomical structure membrane virion component virion membrane viral membrane viral envelope host cell plasma membrane host cellular component host cell part host cell membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR001364	Haemagglutinin, influenzavirus A/B	Family
A, C, E	IPR014831	Haemagglutinin stalk, influenza C	Domain
A, C, E	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
A, C, E	IPR003860	Haemagglutinin-esterase glycoprotein, haemagglutinin domain	Domain
A, C, E	IPR007142	Haemagglutinin-esterase glycoprotein, core	Domain
B, D, F	IPR001364	Haemagglutinin, influenzavirus A/B	Family
B, D, F	IPR014831	Haemagglutinin stalk, influenza C	Domain
B, D, F	IPR008980	Viral capsid/haemagglutinin protein	Homologous Superfamily
B, D, F	IPR003860	Haemagglutinin-esterase glycoprotein, haemagglutinin domain	Domain
B, D, F	IPR007142	Haemagglutinin-esterase glycoprotein, core	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.