2X1W

Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d2x1wc_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2x1wa_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2x1wb_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2x1wd_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Cystine-knot cytokines	8070295	3000846	SCOP2B (2022-06-29)
A	SCOP2 Family	Platelet-derived growth factor-like	8070294	4003427	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cystine-knot cytokines	8070295	3000846	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cystine-knot cytokines	8070295	3000846	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cystine-knot cytokines	8070295	3000846	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PDGF	e2x1wC1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PDGF	ECOD (1.6)
A	PDGF	e2x1wA1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PDGF	ECOD (1.6)
B	PDGF	e2x1wB1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PDGF	ECOD (1.6)
D	PDGF	e2x1wD1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PDGF	ECOD (1.6)
F [auth M]	C1-set_3	e2x1wM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_3	ECOD (1.6)
F [auth M]	IG_like	e2x1wM2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IG_like	ECOD (1.6)
G [auth N]	C1-set_3	e2x1wN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_3	ECOD (1.6)
G [auth N]	IG_like	e2x1wN2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IG_like	ECOD (1.6)
H [auth O]	C1-set_3	e2x1wO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_3	ECOD (1.6)
H [auth O]	IG_like	e2x1wO2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IG_like	ECOD (1.6)
E [auth L]	C1-set_3	e2x1wL4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_3	ECOD (1.6)
E [auth L]	IG_like	e2x1wL3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IG_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
D	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
F [auth M]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth N]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth O]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
E [auth L], F [auth M], G [auth N], H [auth O]	VEGFR2	2C-LIKE	Homo sapiens (human)	KDR*01	C-LIKE-DOMAIN C-LIKE	RPI	(KDR(Pr121-224_d2)-KDR(Pr225-325_d3,326-327))	IMGT (202507-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00341	PDGF/VEGF domain (PDGF)	PDGF/VEGF domain		Domain
E [auth L], F [auth M], G [auth N], H [auth O]	PF21339	Vascular endothelial growth factor receptor 1-like, Ig-like domain (VEGFR-1-like_Ig-like)	Vascular endothelial growth factor receptor 1-like, Ig-like domain	This domain is found in Vascular endothelial growth factor receptor 1 from humans (VEGFR-1) and similar proteins from animals. VEGFR-1 is a tyrosine kinase receptor for the placental growth factor (PlGF) that plays an essential role in the developmen ...	This domain is found in Vascular endothelial growth factor receptor 1 from humans (VEGFR-1) and similar proteins from animals. VEGFR-1 is a tyrosine kinase receptor for the placental growth factor (PlGF) that plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis and other essential cellular processes. It consists of seven immunoglobulin-like (Ig-like) domains in its extracellular portion. This entry represents the second of these domains [1-5].	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	PF00047	Immunoglobulin domain (ig)	Immunoglobulin domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prote ...	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	VASCULAR ENDOTHELIAL GROWTH FACTOR C	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity chemoattractant activity cytokine receptor binding vascular endothelial growth factor receptor binding growth factor receptor binding vascular endothelial growth factor receptor 3 binding	response to stimulus response to chemical response to xenobiotic stimulus developmental process anatomical structure morphogenesis anatomical structure development animal organ development animal organ morphogenesis positive chemotaxis chemotaxis positive regulation of locomotion regulation of biological process regulation of response to external stimulus positive regulation of positive chemotaxis response to stimulus response to chemical response to xenobiotic stimulus developmental process anatomical structure morphogenesis anatomical structure development animal organ development animal organ morphogenesis positive chemotaxis chemotaxis positive regulation of locomotion regulation of biological process regulation of response to external stimulus positive regulation of positive chemotaxis biological regulation positive regulation of biological process response to external stimulus induction of positive chemotaxis regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to stimulus regulation of positive chemotaxis positive regulation of response to external stimulus taxis regulation of response to stimulus regulation of locomotion locomotion multicellular organismal process regulation of developmental process lymphangiogenesis vasculature development circulatory system development positive regulation of developmental process multicellular organism development regulation of lymphangiogenesis anatomical structure formation involved in morphogenesis positive regulation of lymphangiogenesis lymph vessel morphogenesis lymph vessel development regulation of anatomical structure morphogenesis system development regulation of osteoblast differentiation regulation of cellular process cellular developmental process negative regulation of osteoblast differentiation negative regulation of developmental process negative regulation of biological process regulation of cell differentiation osteoblast differentiation ossification cell differentiation negative regulation of cellular process negative regulation of cell differentiation cellular process cellular response to stimulus cellular response to growth factor stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication vascular endothelial growth factor signaling pathway cellular response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus signal transduction response to growth factor enzyme-linked receptor protein signaling pathway regulation of cell motility positive regulation of cell migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration cell migration regulation of immune system process cell motility positive regulation of immune system process positive regulation of cellular process regulation of mast cell chemotaxis cell chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration mast cell migration positive regulation of leukocyte chemotaxis positive regulation of leukocyte migration leukocyte migration positive regulation of mast cell chemotaxis cellular response to chemical stimulus immune system process mast cell chemotaxis leukocyte chemotaxis cell population proliferation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation blood vessel morphogenesis tube development angiogenesis sprouting angiogenesis tube morphogenesis blood vessel development positive regulation of cell division cell division regulation of cell division morphogenesis of embryonic epithelium epithelium development embryonic morphogenesis morphogenesis of an epithelium tissue development embryo development tissue morphogenesis mesenchymal stem cell proliferation regulation of stem cell proliferation positive regulation of mesenchymal stem cell proliferation regulation of mesenchymal stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation substrate-dependent cell migration regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of blood vessel endothelial cell migration positive regulation of endothelial cell migration blood vessel endothelial cell migration regulation of endothelial cell migration protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of signal transduction regulation of vascular endothelial growth factor receptor signaling pathway regulation of signaling regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway regulation of cell communication regulation of vasculature development regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus positive regulation of nervous system development cell development regulation of neurogenesis regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of cell development regulation of nervous system development neurogenesis regulation of glial cell proliferation gliogenesis positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of cell development nervous system development glial cell proliferation neuroblast proliferation regulation of neuroblast proliferation regulation of neural precursor cell proliferation generation of neurons positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation neural precursor cell proliferation response to peptide response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor system process circulatory system process regulation of blood pressure regulation of biological quality negative regulation of blood pressure blood circulation	cellular anatomical structure membrane extracellular region membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cellular anatomical structure membrane extracellular region membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm platelet alpha granule vesicle platelet alpha granule lumen extracellular space
E [auth L], F [auth M], G [auth N], H [auth O]	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane-ephrin receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity collagen receptor activity protein tyrosine kinase collagen receptor activity GPI-linked ephrin receptor activity protein-hormone receptor activity insulin receptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor receptor activity stem cell factor receptor activity cell adhesion molecule binding cadherin binding protein binding brain-derived neurotrophic factor receptor activity neurotrophin receptor activity hepatocyte growth factor receptor activity macrophage colony-stimulating factor receptor activity platelet-derived growth factor alpha-receptor activity growth factor binding vascular endothelial growth factor receptor activity histone H2AXY142 kinase activity histone modifying activity histone kinase activity histone H2AX kinase activity coreceptor activity histone H3Y41 kinase activity histone H3 kinase activity placental growth factor receptor activity insulin-like growth factor receptor activity identical protein binding Hsp90 protein binding heat shock protein binding boss receptor activity epidermal growth factor receptor activity protein-containing complex binding integrin binding signaling receptor binding vascular endothelial growth factor binding fibroblast growth factor receptor activity	multicellular organismal process multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis surfactant homeostasis regulation of cellular process regulation of developmental process cellular developmental process positive regulation of biological process regulation of vasculogenesis regulation of cell differentiation vasculogenesis positive regulation of developmental process multicellular organismal process multicellular organismal-level homeostasis chemical homeostasis homeostatic process multicellular organismal-level chemical homeostasis surfactant homeostasis regulation of cellular process regulation of developmental process cellular developmental process positive regulation of biological process regulation of vasculogenesis regulation of cell differentiation vasculogenesis positive regulation of developmental process multicellular organism development tube morphogenesis positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of cellular process blood vessel development system development developmental process regulation of biological process blood vessel morphogenesis tube development biological regulation vasculature development circulatory system development anatomical structure morphogenesis cellular process positive regulation of vasculogenesis cellular response to stimulus cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication vascular endothelial growth factor signaling pathway cellular response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus signal transduction response to growth factor enzyme-linked receptor protein signaling pathway regulation of multicellular organismal development animal organ development regulation of bone development skeletal system development regulation of multicellular organismal process bone development regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cell adhesion cellular component assembly cell junction assembly positive regulation of cell-substrate adhesion regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly hemopoiesis cell development embryo development embryonic hemopoiesis embryonic organ development branching morphogenesis of an epithelial tube angiogenesis epithelial tube morphogenesis epithelium development morphogenesis of an epithelium tissue development branching involved in blood vessel morphogenesis tissue morphogenesis morphogenesis of a branching structure anatomical structure formation involved in morphogenesis morphogenesis of a branching epithelium inorganic ion homeostasis monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis cell fate commitment positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling positive regulation of mesenchymal cell proliferation cell population proliferation positive regulation of cell population proliferation regulation of mesenchymal cell proliferation regulation of cell population proliferation mesenchymal cell proliferation endothelial cell differentiation endothelium development epithelial cell differentiation cell surface receptor protein serine/threonine kinase signaling pathway regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of BMP signaling pathway BMP signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway response to BMP transforming growth factor beta receptor superfamily signaling pathway heart development endocardium development positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion epithelial cell proliferation positive regulation of autophagy catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process positive regulation of metabolic process regulation of macroautophagy metabolic process positive regulation of macroautophagy process utilizing autophagic mechanism regulation of metabolic process positive regulation of organelle organization regulation of anatomical structure morphogenesis mitochondrion organization organelle fission mitochondrial fission regulation of organelle organization organelle organization regulation of mitochondrial fission regulation of mitochondrion organization positive regulation of mitochondrial fission wound healing angiogenesis involved in wound healing vascular wound healing response to stress response to wounding negative regulation of endothelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process regulation of biosynthetic process negative regulation of metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of macromolecule metabolic process endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation vascular endothelial growth factor receptor signaling pathway lymph vessel development respiratory tube development lung development respiratory system development lung alveolus development protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process camera-type eye morphogenesis sensory organ development eye development post-embryonic camera-type eye development visual system development post-embryonic camera-type eye morphogenesis eye morphogenesis post-embryonic eye morphogenesis sensory organ morphogenesis camera-type eye development animal organ morphogenesis post-embryonic development sensory system development cellular response to chemical stimulus response to chemical cellular response to hydrogen sulfide response to hydrogen sulfide regulation of mitochondrial depolarization positive regulation of membrane depolarization positive regulation of mitochondrial depolarization mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization regulation of biological quality regulation of membrane potential cell migration involved in sprouting angiogenesis sprouting angiogenesis regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation gonad development reproductive system development reproductive process female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development vascular endothelial growth factor receptor-2 signaling pathway developmental maturation epithelial cell development anatomical structure maturation epithelial cell maturation cell maturation positive regulation of cell migration involved in sprouting angiogenesis regulation of cell migration involved in sprouting angiogenesis blood vessel endothelial cell differentiation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of cell shape cell morphogenesis regulation of cell morphogenesis positive chemotaxis chemotaxis regulation of response to external stimulus positive regulation of positive chemotaxis response to external stimulus regulation of chemotaxis positive regulation of chemotaxis regulation of positive chemotaxis positive regulation of response to external stimulus taxis positive regulation of endothelial cell chemotaxis endothelial cell chemotaxis cell chemotaxis regulation of endothelial cell chemotaxis semaphorin-plexin signaling pathway regulation of vasculature development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process regulation of phosphorus metabolic process regulation of phosphorylation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation	protein-containing complex receptor complex membrane-bounded organelle intracellular anatomical structure sorting endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm protein-containing complex receptor complex membrane-bounded organelle intracellular anatomical structure sorting endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle cell periphery plasma membrane membrane membrane microdomain membrane raft extracellular region cell surface external side of plasma membrane side of membrane Golgi apparatus cell junction anchoring junction early endosome nucleus endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B, C, D	IPR023581	Platelet-derived growth factor, conserved site	Conserved Site
A, B, C, D	IPR000072	PDGF/VEGF domain	Domain
A, B, C, D	IPR004153	CXCXC repeat	Repeat
A, B, C, D	IPR050507	Platelet-derived/Vascular endothelial growth factor	Family
E [auth L], F [auth M], G [auth N], H [auth O]	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site	Conserved Site
E [auth L], F [auth M], G [auth N], H [auth O]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
E [auth L], F [auth M], G [auth N], H [auth O]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR000719	Protein kinase domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR003599	Immunoglobulin domain subtype	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR013151	Immunoglobulin-like beta-sandwich domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
E [auth L], F [auth M], G [auth N], H [auth O]	IPR007110	Immunoglobulin-like domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR017441	Protein kinase, ATP binding site	Binding Site
E [auth L], F [auth M], G [auth N], H [auth O]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR041348	VEGFR-2, transmembrane domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR008266	Tyrosine-protein kinase, active site	Active Site
E [auth L], F [auth M], G [auth N], H [auth O]	IPR009136	Vascular endothelial growth factor receptor 2 (VEGFR2)	Family
E [auth L], F [auth M], G [auth N], H [auth O]	IPR055229	VEGFR1-3, fifth immunoglobulin-like domain	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR003598	Immunoglobulin subtype 2	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR013098	Immunoglobulin I-set	Domain
E [auth L], F [auth M], G [auth N], H [auth O]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
E [auth L], F [auth M], G [auth N], H [auth O]	IPR050122	Receptor Tyrosine Kinase	Family
E [auth L], F [auth M], G [auth N], H [auth O]	IPR055238	VEGFR1-3, N-terminal Ig-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P49767	lymphedema, hereditary, 1D melanoma angiosarcoma breast carcinoma breast cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis adenoma cutaneous melanoma hereditary lymphedema Malignant neoplasm of breast ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast fibroadenoma lymphedema, hereditary, 1D melanoma angiosarcoma breast carcinoma breast cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis adenoma cutaneous melanoma hereditary lymphedema Malignant neoplasm of breast ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast fibroadenoma cystic fibrosis lymphatic system disease malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer cancer gastric carcinoma lymphedema malignant mesothelioma
E [auth L], F [auth M], G [auth N], H [auth O]	Pharos: P35968	angiosarcoma capillary infantile hemangioma non-small cell lung carcinoma tubular adenocarcinoma adenocarcinoma Venous Thrombosis schizophrenia temporal lobe epilepsy esophageal cancer uremia cancer multiple epiphyseal dysplasia granular cell carcinoma breast carcinoma osteochondrodysplasia angiosarcoma capillary infantile hemangioma non-small cell lung carcinoma tubular adenocarcinoma adenocarcinoma Venous Thrombosis schizophrenia temporal lobe epilepsy esophageal cancer uremia cancer multiple epiphyseal dysplasia granular cell carcinoma breast carcinoma osteochondrodysplasia colorectal cancer lung adenocarcinoma major depressive disorder diabetic kidney disease spondyloepiphyseal dysplasia tarda, X-linked endometrial carcinoma malignant pancreatic neoplasm thyroid gland follicular carcinoma medullary thyroid gland carcinoma facioscapulohumeral muscular dystrophy gastrointestinal stromal tumor myocardial ischemia hepatocellular carcinoma breast disease hypertensive disorder ovarian cancer pancreatic neoplasm colorectal carcinoma intracerebral hemorrhage renal cell carcinoma coronary artery disease kidney disease lung cancer cystic fibrosis malignant ependymoma sinusitis endometriosis thyroid gland papillary carcinoma Melnick-Needles syndrome ulcerative colitis gastric adenocarcinoma glioblastoma neoplasm of esophagus breast cancer idiopathic pulmonary fibrosis pancreatic intraductal papillary-mucinous carcinoma interstitial lung disease invasive ductal breast carcinoma cribriform carcinoma lung disease Schwartz-Jampel syndrome malignant mesothelioma spondyloepiphyseal dysplasia thymic carcinoma transitional cell carcinoma gastric cancer interstitial cystitis pancreatic intraductal papillary-mucinous neoplasm intestinal disease ischemia reperfusion injury cribriform carcinoma of breast