3CYI

Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ATP:Mg2+

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3cyia1	Alpha and beta proteins (a+b)	ParB/Sulfiredoxin	ParB/Sulfiredoxin	Sulfiredoxin-like	Sulfiredoxin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3cyia2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ParB/Sulfiredoxin	8033419	3001301	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ParBc	e3cyiA1	A: a+b complex topology	X: ParB/Sulfiredoxin (From Topology)	H: ParB/Sulfiredoxin (From Topology)	T: ParB/Sulfiredoxin	F: ParBc	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.1530.10	Alpha Beta	Alpha-Beta Complex	Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain	Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sulfiredoxin-1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding oxidoreductase activity, acting on a sulfur group of donors oxidoreductase activity catalytic activity antioxidant activity sulfiredoxin activity	response to oxidative stress response to stimulus response to stress cellular response to stimulus cellular response to chemical stimulus cellular response to stress response to chemical cellular response to oxidative stress cellular process cellular response to chemical stress	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016692	Sulfiredoxin	Family
A	IPR036086	ParB/Sulfiredoxin superfamily	Homologous Superfamily
A	IPR003115	ParB/Sulfiredoxin	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BYN0	psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.