3R8J

Crystal structure of human SOUL protein (orthorhombic form)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3r8ja_	Alpha and beta proteins (a+b)	Probable bacterial effector-binding domain	Probable bacterial effector-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3r8jb_	Alpha and beta proteins (a+b)	Probable bacterial effector-binding domain	Probable bacterial effector-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Probable bacterial effector-binding domain	8089092	3000062	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Probable bacterial effector-binding domain	8089092	3000062	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SOUL	e3r8jA1	A: a+b duplicates or obligate multimers	X: Probable bacterial effector-binding domain (From Topology)	H: Probable bacterial effector-binding domain (From Topology)	T: Probable bacterial effector-binding domain	F: SOUL	ECOD (1.6)
B	SOUL	e3r8jB1	A: a+b duplicates or obligate multimers	X: Probable bacterial effector-binding domain (From Topology)	H: Probable bacterial effector-binding domain (From Topology)	T: Probable bacterial effector-binding domain	F: SOUL	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.80.10	Alpha Beta	Alpha-Beta Barrel	Multidrug-efflux Transporter 1 Regulator Bmrr	Chain A	CATH (4.3.0)
B	3.20.80.10	Alpha Beta	Alpha-Beta Barrel	Multidrug-efflux Transporter 1 Regulator Bmrr	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF04832	SOUL heme-binding protein (SOUL)	SOUL heme-binding protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Heme-binding protein 2	binding organic cyclic compound binding tetrapyrrole binding heme binding	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole secretory granule lumen azurophil granule lumen organelle lumen secretory granule primary lysosome secretory vesicle extracellular region extracellular exosome extracellular vesicle extracellular organelle extracellular space extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006917	SOUL haem-binding protein	Family
A, B	IPR011256	Regulatory factor, effector binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y5Z4	liver cancer ulcerative colitis atypical teratoid rhabdoid tumor esophageal adenocarcinoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor breast fibroadenoma glioblastoma liver neoplasm malignant glioma osteosarcoma pilocytic astrocytoma spina bifida liver cancer ulcerative colitis atypical teratoid rhabdoid tumor esophageal adenocarcinoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor breast fibroadenoma glioblastoma liver neoplasm malignant glioma osteosarcoma pilocytic astrocytoma spina bifida cystic fibrosis large cell medulloblastoma lung cancer malignant mesothelioma ovarian cancer plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.