5JKB | pdb_00005jkb

Crystal structure of human JUNO (crystal form 2)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Frizzled domain-like	8090926	3001950	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Frizzled domain-like	8090926	3001950	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Frizzled domain-like	8090926	3001950	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Frizzled domain-like	8090926	3001950	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Folate_rec	e5jkbC1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
A	Folate_rec	e5jkbA1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
B	Folate_rec	e5jkbB1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
D	Folate_rec	e5jkbD1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03024	Folate receptor family (Folate_rec)	Folate receptor family	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins co ...	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Sperm-egg fusion protein Juno	molecular transducer activity signaling receptor activity protein binding binding signaling receptor binding	membrane organization sexual reproduction membrane fusion reproductive process plasma membrane fusion fertilization multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism cellular component organization fusion of sperm to egg plasma membrane involved in single fertilization plasma membrane organization cellular process cellular component organization or biogenesis endomembrane system organization membrane organization sexual reproduction membrane fusion reproductive process plasma membrane fusion fertilization multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism cellular component organization fusion of sperm to egg plasma membrane involved in single fertilization plasma membrane organization cellular process cellular component organization or biogenesis endomembrane system organization single fertilization sperm-egg recognition cell-cell recognition cell recognition cell adhesion	membrane plasma membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane cell surface external side of plasma membrane side of membrane membrane plasma membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane cell surface external side of plasma membrane side of membrane extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004269	Folate receptor	Family
A, B, C, D	IPR018143	Folate receptor-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: A6ND01	obstructive sleep apnea syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.