7TZ2

Structure of human Fibrinogen-like protein 1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8107640	3001395	SCOP2B (2022-06-29)
B	SCOP2 Family	Fibrinogen C-terminal domain-like	8107639	4002544	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Fibrinogen C-terminal domain-like	8107640	3001395	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8107640	3001395	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fibrinogen_C	e7tz2A1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: Fibrinogen_C	ECOD (1.6)
B	Fibrinogen_C	e7tz2B1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: Fibrinogen_C	ECOD (1.6)
C	Fibrinogen_C	e7tz2C1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: Fibrinogen_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.215.10	Alpha Beta	Alpha-Beta Complex	Gamma Fibrinogen	Chain A, domain 1	CATH (utative)
B	3.90.215.10	Alpha Beta	Alpha-Beta Complex	Gamma Fibrinogen	Chain A, domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00147	Fibrinogen beta and gamma chains, C-terminal globular domain (Fibrinogen_C)	Fibrinogen beta and gamma chains, C-terminal globular domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Fibrinogen-like protein 1	protein binding binding signaling receptor binding	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process response to stimulus immune response immune system process adaptive immune response multicellular organismal process regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process response to stimulus immune response immune system process adaptive immune response multicellular organismal process regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis biological regulation platelet aggregation blood coagulation cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation regulation of biological process regulation of response to stimulus regulation of immune response regulation of immune system process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte cell-cell adhesion negative regulation of cell adhesion leukocyte activation T cell activation negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion regulation of cell adhesion regulation of T cell activation negative regulation of cell activation negative regulation of T cell activation negative regulation of immune system process negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation developmental process cell population proliferation gland development animal organ development epithelial cell proliferation involved in liver morphogenesis liver development multicellular organism development anatomical structure morphogenesis gland morphogenesis hepatocyte proliferation hepaticobiliary system development anatomical structure development animal organ morphogenesis epithelial cell proliferation liver morphogenesis system development	protein-containing complex cellular anatomical structure extracellular region extracellular space fibrinogen complex cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR037579	Fibrinogen/angiopoietin-like	Family
A, B, C	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
A, B, C	IPR020837	Fibrinogen, conserved site	Conserved Site
A, B, C	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily
A, B, C	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q08830	large cell medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.