8GT0 | pdb_00008gt0

Structure of falcipain and human Stefin A complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cysteine proteinases	8035179	3001808	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cysteine proteinases	8035179	3001808	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cystatin/monellin	8043729	3000441	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cystatin/monellin	8043729	3000441	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF00112	Papain family cysteine protease (Peptidase_C1)	Papain family cysteine protease		Domain
B, D	PF00031	Cystatin domain (Cystatin)	Cystatin domain	Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. All members except Swiss:Q03196 and Swiss:Q1 ...	Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. All members except Swiss:Q03196 and Swiss:Q10993 are found. Pfam:PF00666 are related to this family but have not been included.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Cysteine protease falcipain-2	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity	catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process	cellular anatomical structure membrane extracellular region extracellular space membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle food vacuole intracellular organelle cellular anatomical structure membrane extracellular region extracellular space membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle food vacuole intracellular organelle cytoplasmic vesicle organelle secondary lysosome cytoplasm vesicle endocytic vesicle lysosome
B, D	Cystatin-A	enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein hydrolase activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity cysteine-type peptidase activity molecular function inhibitor activity molecular function regulator activity cysteine-type endopeptidase activity catalytic activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein hydrolase activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity cysteine-type peptidase activity molecular function inhibitor activity molecular function regulator activity cysteine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding enzyme binding protease binding	developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process negative regulation of hydrolase activity developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process negative regulation of hydrolase activity negative regulation of proteolysis regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of molecular function regulation of peptidase activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of hydrolase activity metabolic process macromolecule metabolic process regulation of metabolic process cell adhesion cell-cell adhesion peptide cross-linking macromolecule modification protein modification process	protein-containing complex peptidase inhibitor complex cell periphery cellular anatomical structure plasma membrane membrane cornified envelope intracellular anatomical structure cytoplasm cytosol extracellular region extracellular space membrane-bounded organelle nucleus protein-containing complex peptidase inhibitor complex cell periphery cellular anatomical structure plasma membrane membrane cornified envelope intracellular anatomical structure cytoplasm cytosol extracellular region extracellular space membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR000169	Cysteine peptidase, cysteine active site	Active Site
A, C, E	IPR013128	Peptidase C1A	Family
A, C, E	IPR000668	Peptidase C1A, papain C-terminal	Domain
A, C, E	IPR013201	Cathepsin propeptide inhibitor domain (I29)	Domain
A, C, E	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A, C, E	IPR025660	Cysteine peptidase, histidine active site	Active Site
A, C, E	IPR039417	Papain-like cysteine endopeptidase	Domain
B, D	IPR018073	Proteinase inhibitor I25, cystatin, conserved site	Conserved Site
B, D	IPR001713	Proteinase inhibitor I25A, stefin	Family
B, D	IPR000010	Cystatin domain	Domain
B, D	IPR046350	Cystatin superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: P01040	peeling skin syndrome 4 glioblastoma nasopharyngeal carcinoma psoriasis giant cell glioblastoma Neoplasm Metastasis malignant pancreatic neoplasm nephrolithiasis pancreatic ductal adenocarcinoma peeling skin syndrome acne atypical teratoid rhabdoid tumor spina bifida cystic fibrosis lung cancer peeling skin syndrome 4 glioblastoma nasopharyngeal carcinoma psoriasis giant cell glioblastoma Neoplasm Metastasis malignant pancreatic neoplasm nephrolithiasis pancreatic ductal adenocarcinoma peeling skin syndrome acne atypical teratoid rhabdoid tumor spina bifida cystic fibrosis lung cancer malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm acral peeling skin syndrome sinusitis B-cell chronic lymphocytic leukemia subependymal giant cell astrocytoma dermatomyositis esophageal adenocarcinoma lung carcinoma malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma asthma Sjogren syndrome breast cancer ulcerative colitis exfoliative ichthyosis lung adenocarcinoma malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.