Annotations: 9IV8

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03160	Calx-beta domain (Calx-beta)	Calx-beta domain		Domain
A	PF16494	C-terminal extension of sodium/calcium exchanger domain (Na_Ca_ex_C)	C-terminal extension of sodium/calcium exchanger domain	-	Family
A	PF01699	Sodium/calcium exchanger protein (Na_Ca_ex)	Sodium/calcium exchanger protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sodium/calcium exchanger 1	monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity calcium:monoatomic cation antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity calcium:sodium antiporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity calcium:monoatomic cation antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity calcium:sodium antiporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding ankyrin binding protein binding binding calmodulin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding transmembrane transporter binding	membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process regulation of biological process regulation of cardiac conduction regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation cardiac conduction regulation of multicellular organismal process heart contraction blood circulation regulation of heart rate positive regulation of the force of heart contraction regulation of the force of heart contraction localization transport monoatomic ion transport establishment of localization regulation of biosynthetic process regulation of cellular process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process sodium ion export across plasma membrane monoatomic ion transmembrane transport sodium ion transmembrane transport export from cell inorganic ion transmembrane transport export across plasma membrane metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic cation transport sodium ion transport cellular response to nitrogen compound cellular response to stimulus response to stimulus cellular response to caffeine response to nitrogen compound response to purine-containing compound response to alkaloid cellular response to chemical stimulus response to chemical cellular response to alkaloid cellular response to purine-containing compound response to caffeine inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of developmental process positive regulation of biological process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification calcium ion transport calcium ion transmembrane transport calcium ion import negative regulation of cytosolic calcium ion concentration regulation of calcium ion transport regulation of localization negative regulation of biological process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cardiac muscle contraction intracellular signal transduction cell communication intracellular signaling cassette signal transduction release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport regulation of cardiac muscle contraction muscle contraction maintenance of location release of sequestered calcium ion into cytosol regulation of transmembrane transport regulation of striated muscle contraction calcium-mediated signaling regulation of muscle contraction cellular localization signaling regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion maintenance of location in cell striated muscle contraction regulation of calcium ion transmembrane transport negative regulation of cellular process regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of cardiac muscle contraction by calcium ion signaling regulation of transport sequestering of calcium ion muscle system process regulation of muscle system process regulation of monoatomic cation transmembrane transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium ion export sodium ion homeostasis intracellular sodium ion homeostasis relaxation of cardiac muscle relaxation of muscle positive regulation of cytosolic calcium ion concentration calcium ion transport into cytosol regulation of cell communication regulation of cell communication by electrical coupling cell communication by electrical coupling cell communication by electrical coupling involved in cardiac conduction cell communication involved in cardiac conduction relaxation of smooth muscle import into cell import across plasma membrane inorganic cation import across plasma membrane calcium ion import across plasma membrane inorganic ion import across plasma membrane calcium ion import into cytosol sodium ion import across plasma membrane regulation of tube diameter vascular associated smooth muscle contraction regulation of tube size smooth muscle contraction vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to stress response to stress regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process negative regulation of protein serine/threonine kinase activity phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process phosphorus metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of molecular function primary metabolic process negative regulation of protein kinase activity regulation of protein kinase activity regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of protein serine/threonine kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation cardiac muscle cell development cellular developmental process cell development muscle cell differentiation striated muscle tissue development muscle structure development striated muscle cell development muscle cell development cell differentiation cardiac cell development muscle tissue development system development heart development cardiac muscle tissue development cardiac muscle cell differentiation cardiocyte differentiation circulatory system development striated muscle cell differentiation response to mechanical stimulus response to abiotic stimulus response to external stimulus response to muscle stretch	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body axon cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone postsynapse synapse membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse axon terminus presynapse distal axon neuron projection terminus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032452	Sodium/calcium exchanger domain, C-terminal extension	Domain
A	IPR044880	NCX, central ion-binding domain superfamily	Homologous Superfamily
A	IPR003644	Na-Ca exchanger/integrin-beta4	Domain
A	IPR051171	Calcium/Cation Antiporter	Family
A	IPR004837	Sodium/calcium exchanger membrane region	Domain
A	IPR001623	DnaJ domain	Domain
A	IPR004836	Sodium/calcium exchanger protein	Family
A	IPR038081	CalX-like domain superfamily	Homologous Superfamily
A	IPR002987	Sodium/calcium exchanger, isoform 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P32418	status epilepticus Myocardial Reperfusion Injury visual epilepsy megacolon hydrolethalus syndrome malignant colon neoplasm malignant pancreatic neoplasm myocardial ischemia attention deficit hyperactivity disorder, inattentive type chronic obstructive pulmonary disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm cystic fibrosis Pick disease exocrine pancreatic carcinoma status epilepticus Myocardial Reperfusion Injury visual epilepsy megacolon hydrolethalus syndrome malignant colon neoplasm malignant pancreatic neoplasm myocardial ischemia attention deficit hyperactivity disorder, inattentive type chronic obstructive pulmonary disease osteosarcoma pancreatic intraductal papillary-mucinous neoplasm cystic fibrosis Pick disease exocrine pancreatic carcinoma primitive neuroectodermal tumor malignant ependymoma medulloblastoma tuberculosis astrocytic tumor atypical teratoid rhabdoid tumor ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma psoriasis glioblastoma head and neck cancer large cell medulloblastoma malignant glioma Sjogren syndrome ulcerative colitis non-small cell lung carcinoma bone disease oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma coronary artery disease pituitary cancer

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.