Annotations: 9JDM

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth B], D [auth C]	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat
A, B [auth D], C [auth B], D [auth C]	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat
A, B [auth D], C [auth B], D [auth C]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth B], D [auth C]	Transient receptor potential cation channel subfamily V member 3	monoatomic cation transmembrane transporter activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity calcium channel activity calcium ion transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport cellular process calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport cellular response to stimulus response to osmotic stress regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular response to chemical stress cellular response to osmotic stress intracellular signal transduction cellular response to environmental stimulus cell communication cellular response to chemical stimulus osmosensory signaling pathway cellular response to stress response to stress response to chemical response to abiotic stimulus cellular response to abiotic stimulus signal transduction regulation of calcium ion import regulation of calcium ion transport regulation of localization positive regulation of calcium ion transport positive regulation of calcium ion import regulation of transport regulation of monoatomic ion transport positive regulation of biological process positive regulation of transport positive regulation of monoatomic ion transport regulation of metal ion transport cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization negative regulation of hair cycle multicellular organismal process hair cycle molting cycle negative regulation of biological process regulation of hair cycle regulation of multicellular organismal process negative regulation of multicellular organismal process response to temperature stimulus	protein-containing complex receptor complex membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection cell periphery plasma membrane membrane intracellular anatomical structure cytoplasm intracellular organelle protein-containing complex receptor complex membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection cell periphery plasma membrane membrane intracellular anatomical structure cytoplasm intracellular organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth B], D [auth C]	IPR002110	Ankyrin repeat	Repeat
A, B [auth D], C [auth B], D [auth C]	IPR005821	Ion transport domain	Domain
A, B [auth D], C [auth B], D [auth C]	IPR008347	Transient receptor potential cation channel subfamily V member 1-4	Family
A, B [auth D], C [auth B], D [auth C]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B [auth D], C [auth B], D [auth C]	IPR024862	Transient receptor potential cation channel subfamily V	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth D], C [auth B], D [auth C]	Pharos: Q8NET8	isolated focal non-epidermolytic palmoplantar keratoderma palmoplantar keratosis Olmsted syndrome 1 erythrokeratoderma Generalized pustular psoriasis Olmsted syndrome peeling skin syndrome psoriasis

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth D], C [auth B], D [auth C]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth D], C [auth B], D [auth C]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.