Annotations: 9L3Z

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	Cytochromes	8057879	3001526	SCOP2B (2022-06-29)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H]	Heavy Chain	IGHV3	-	chemerin-like receptor 1,soluble cytochrome b562	SAbDab (2025-05-02)
B [auth L]	Light Chain	IGKV1	Kappa	chemerin-like receptor 1,soluble cytochrome b562	SAbDab (2025-05-02)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF07361	Cytochrome b562 (Cytochrom_B562)	Cytochrome b562	-	Family
C [auth A]	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GC ...	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H]	The heavy chain of anti-BRIL Fab	-	-	-
B [auth L]	The light chain of anti-BRIL Fab	-	-	-
C [auth A]	Chemerin-like receptor 1,Soluble cytochrome b562	amide binding binding adipokinetic hormone binding peptide hormone binding hormone binding molecular transducer activity signaling receptor activity protein-hormone receptor activity adipokinetic hormone receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity G protein-coupled chemoattractant receptor activity chemokine receptor activity cytokine receptor activity amide binding binding adipokinetic hormone binding peptide hormone binding hormone binding molecular transducer activity signaling receptor activity protein-hormone receptor activity adipokinetic hormone receptor activity G protein-coupled receptor activity transmembrane signaling receptor activity G protein-coupled chemoattractant receptor activity chemokine receptor activity cytokine receptor activity immune receptor activity complement receptor activity tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to stimulus immune response immune system process developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development cellular response to stimulus immune response-regulating cell surface receptor signaling pathway positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality response to stimulus immune response immune system process developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process complement receptor mediated signaling pathway signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway regulation of response to stimulus regulation of immune response cellular process activation of immune response negative regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process negative regulation of NF-kappaB transcription factor activity nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of locomotion regulation of cell motility macrophage migration positive regulation of chemotaxis positive regulation of cell migration taxis cell migration regulation of mononuclear cell migration chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of macrophage migration response to external stimulus positive regulation of leukocyte chemotaxis granulocyte migration leukocyte migration response to chemical regulation of locomotion regulation of response to external stimulus macrophage chemotaxis regulation of granulocyte chemotaxis regulation of macrophage migration positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration cell motility locomotion positive regulation of cellular process cell chemotaxis regulation of macrophage chemotaxis positive regulation of leukocyte migration regulation of chemotaxis cellular response to chemical stimulus granulocyte chemotaxis mononuclear cell migration positive regulation of macrophage chemotaxis leukocyte chemotaxis homeostatic process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of signaling regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction calcium-mediated signaling intracellular signaling cassette regulation of calcium-mediated signaling regulation of cell communication defense response response to stress inflammatory response negative regulation of biological process regulation of interleukin-12 production negative regulation of interleukin-12 production cytokine production negative regulation of cellular process regulation of cytokine production interleukin-12 production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process fat cell differentiation positive regulation of fat cell differentiation regulation of developmental process cellular developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of fat cell differentiation electron transport chain generation of precursor metabolites and energy	cellular anatomical structure membrane cell periphery plasma membrane periplasmic space
D [auth C]	LRH7-C2	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
C [auth A]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
C [auth A]	IPR000826	Formyl peptide receptor-related	Family
C [auth A]	IPR002258	Chemerin-like receptor 1	Family
C [auth A]	IPR010980	Cytochrome c/b562	Homologous Superfamily
C [auth A]	IPR009155	Cytochrome b562	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A]	Pharos: Q99788	adrenal cortex carcinoma cutaneous lupus erythematosus interstitial cystitis medulloblastoma attention deficit hyperactivity disorder, inattentive type depressive disorder lung adenocarcinoma Mental Depression bipolar disorder granulosa cell tumor lung carcinoma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
C [auth A]	PDBTM	Annotated as membrane protein by PDBTM

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
D [auth C]	DTR	RESID: AA0198 PSI-MOD : D-tryptophan MOD:00205

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.