CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257 ?
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	Clotrimazolum Clotrimazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole Clotrimazol 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(o-Chlorotrityl)imidazole 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
Brand Names	Clotrimazole and Betamethasone Dipropionate Anti-Fungal Cream Walgreens Clotrimazole 3 Gehwol Fusskraft Nail and Skin Protection SIMPLY VITAL Antifungal Cream Clotrimazol Dual Myclo Crm 10mg Canesten 1% Topical Solution Neo-zol Cream 1% JiDeSheng meijer Athletes Foot Scheinpharm Clotrimazole 1% Thera plus Antifungal Clotrimazole Clotrimazole External Cream Canesten Crm 1% Top Jock Itch Clotrimazole Antifungal Footlogix Family Care Antifungal Fungicure Manicure Pedicure Liquid Gel Anti Fungal Healthy Accents Antifungal Mycelex Canesten Comfortab 3 Myclo-derm Cream 1% UpandUp Clotrimazole Western Family Athletes Foot Canesten Comfortab 1 Fungicure Manicure Pedicure Anti Fungal Smooth Gator Fungus Eliminator Clotrimazole Cream 1% Rugby Clotrimazole Antifungal Cream Lakesia Kleer-Plex Fungistat Fungus Cure Fungicure Pumpspray Myclo Crm 50mg Walgreens Jock Itch CVSHealth Antifungal Canesten Extra Strength External Antifungal Cream Astonea Clotrimazole 1% Athletes Foot Akin Anti-fungal Major Clotrimazole Athletes Foot Antifungal Antifungal Extra Strength Clotrimazole Extra Fort -fluconazole Combi Canesten 1 Day Internal Cream Shield and Protect Anti-Fungal Lotrimin WinCo Antifungal Footlogix Intensive Care Diabetic Formula CVS Antifungal Ringworm Dermatin Antifungal Anti-Fungal Gehwol Nail Protection Pen Fungistat Max Best Choice Clotrimazole PerfectHeal Antifungal Aspiera Anti-Fungal Terrasil Jock-Itch Treatment MAX Neo-zol Vaginal Cream 2% Canesten Combi 1 Day Equaline Clotrimazole Antifungal Canesten 2% Vaginal Cream FungaZoil Advanced Oheal Ringworm Cream 1MED Clotrimazole 1% Antifungal Cream Terrasil Athletes Foot AntiFungal Treatment Max Terrasil Tinea Treatment MAX Terrasil Tinea Treatment Maximum Strength CAREONE Clotrimazole Terrasil Jock Itch Treatment Maximum Strength Gehwol med Foot Clotrimazole Antifungal Signature Care Antifungal Protective Nail and skin Terrasil Foot and Nail Anti-Fungal Maximum Strength Terrasil Anti-Fungal Treatment MAX Atopalm Clotrimazole Antifungal Clotrimazole 1% Canesten External Antifungal Cream Forticept Antifungal Cooling Family Wellness Clotrimazole 1 Anti Fungal Cream Terrasil Anti-fungal Treatment Kleer-Plex Fungistat Athlete Foot Cure DermacinRx Therazole Pak Ringworm Canesten 100mg Vaginal Inserts Clotrimazole Ciclomazole Cura Hongo Antifungal CVS Clotrimazole Maximum Strength Canesten Combi-pak 1 Day Therapy Canesten 3 Day Internal Cream Gyne-Lotrimin 7 Kerasal foot and toe Occulus Skin Hydrating Topical Foam CLO-1 Antifungal Desenex Kroger ATHLETES FOOT Our Family Athletes Foot Antifungal Cream Jock-eze Aptrimazole 1.0% Antifungal Cream Canesten Vaginal Inserts 100mg Myclo-derm Solution 1% Exchange Select Atheletes foot S-Cream CLOTRIMAZOLE Cream 1% Myclo Tab 100mg Pedesil Soothing Antifungal Cream Canesten Liq 1% Clotrimazole/Betameth Walgreens Clotrimazole Canesten 1% Topical Cream Family Wellness Antifungal Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Au Kah Chuen Antifungal Fungicure Liquid Gel Clotrimaderm-fluconazole Combi-pack Terrasil JockItch Treatment Maximum Strength Topcare Athletes Foot PRO-EX Anti Fungal Alevazol Terrasil Anti-Fungal Treatment PMS-clotrimazole-betamethasone Kroger Jock Itch Clotrimazole Vaginal 6 Equate Jock Itch First Aid Research Antifungal Cream 1oz ShopRite antifungal Canesten 1 Vaginal Tablet Combi-pak Meijer Athletes Foot Cream AF Clotrimaderm Topical Solution 1% USP Dr Sheffield Athletes Foot Clotrimazol TopCare Antifungal Zapotol Clotrimazole Clotrimaderm External Cream Hua Tuo Xian Gao Lotrisone Canesten 6 Day Internal Cream Jock Itch Antifungal Clotrimazole Topical Solution 1% Signature Care Athletes Foot Family Care Clotrimazole Anti-Fungal Cream 1% Lotriderm WinCo Foods Antifungal Rugby Antifungal Clotrimazole Clotrimaderm Topical Budpak Antifungal Clotrimazole Lotrimin Antifungal Silka Ringworm Fastrin Anti - Fungal Skin Care Taro-clotrimazole/betamethasone Dipropionate TM-Clotrimazole First Aid Research Antifungal .5oz Fungicure Intensive Signature Care Jock Itch Clotrimazole Athletes Foot CAREALL Clotrimazole Mycozyl AC Athlete Foot Cream with Clotrimazole Walgreens Clotrimazole Antifungal Smart Sense Athletes Foot Antifungal Botanimedix TineaRX Antifungal Drying Emulsion Canesten Soft Capsule 1 Forticept Antifungal Foot Cream Lucky SuperSoft Athletes Foot Protective and Moisturizing Skin Canesten Combi 1 Day Internal + External Creams Rexall Jock Itch Foot Care Clotrimazole TopCare Clotrimazole 3 Pedesil Maximum Strength Good Sense Athletes Foot antifungal Canesten Combi 1 Day Comfortab + Extra Strength External Cream meijer Clotrimazole 3 Femmesil Skin Repair Sunmark Clotrimazole Up and Up Athletes Foot Goodsense Athletes Foot Canesten 200 Mg Vaginal Inserts Myclo Solution MakeSense Family Care Clotrimazole Antifungal Betamethasone Clotrimazole CVS Pharmacy ITCH RELIEF ANTIFUNGAL Forticept Antifungal Foot Gel Clotrimazole Topical Solution USP, 1% Jock Itch Cream with Clotrimazole Leader Athletes Foot Clotrimazole Canesoral Combi Antifungal Foot Canesten External Cream Canesten V Equaline Antifungal Cream Terbinafine HCl Chlortimazole and Tolnaftate Terrasil Foot and Nail Anti-Fungal Good Neighbor Pharmacy Clotrimazole Blossom Pharmaceuticals Antifungal Leader Clotrimazole Anti-Fungal Terrasil Rapid-Clear Anti-Fungal Rite Aid antifungal ringworm Terrasil Ringworm Treatment MAX Clotrimaderm Vaginal 6 SoundBody Clotrimazole Antifungal Terrasil Antifungal Cream Maximum Strength TheraPlus Plus ClotrimazOil Antifungal Hua Tuo Xian Gao Antifungal Canesten Crm 1% Vag TerrasilMed ANTIFUNGAL Quality Choice Clotrimazole Canesten Combi 3 Day Good Neighbor Pharmacy Clotrimazole 3 Canesoral Combi 1 Day Clotrimazole 1% Athletes Foot Olp Clotrimazole Micotrin AC Rexall Athletes Foot Up and Up Jock Itch Relief Jock Itch Neo-zol Vaginal Cream 1% Gerlasan Hand CVS Pharmacy Clotrimazole 3 Myclo-gyne Inserts Clotrimazole-fluconazole Combi Live Better Antifungal Athletes Foot Clotrimazole Extra Strength External Antifungal Cream Fortinia Votriza-AL Meijer Clotrimazole Antifungal Fortinia OF Gyne-Lotrimin 3 Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Quality Choice Athletes Foot Athlete s Foot Afac Clotrimazole External Antifungal Cream Clotrimazole Vaginal 3 Myclo-gyne Cream 1% Clotrimazole Jock Itch HEB Antifungal Clotrimazole Topical Clotrimaderm Vaginal 3 sunmark Clotrimazole 3 Dynarex Antifungal Shopko Athletes Foot Canesten 3 Vaginal Tablet Combi-pak Publix athletic foot Clotrimazole 1% Topical Antifungal Cream Oheal Manuka Honey Eczema Cream Fungicure Manicure Pedicure
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682