Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Synonyms
Clonidina
2-((2,6-Dichlorophenyl)imino)imidazolidine
Clonidinum
2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
Clonidine
Clonidin
Chlofazoline
Clonidine hydrochloride
Brand Names
Clonidine Hydrochloride Extended-Release
Catapres-TTS
Catapres-TTS-2
Sandoz Clonidine
Mar-clonidine
Ntp-clonidine
Clonidine
Nu-clonidine Tab 0.2mg
Clonidine hydrochloride extended-release
Nexiclon XR
Catapres
Apo-clonidine Tab 0.2mg
Clorpres
Teva-clonidine
Clonidine hydrochloride
Clonidine Transdermal System USP, 0.3 mg/day
Nexiclon
Clonidine Hci
Dom-clonidine
Catapres Tab 0.2mg
Apo-clonidine Tab 0.1mg
Combipres 0.1/15 Tab
Catapres-TTS-3
Clonidine Transdermal System USP, 0.2 mg/day
Nu-clonidine Tab 0.1mg
Duraclon
Apo-clonidine
Catapres Tab 0.1mg
Clonidine transdermal system
Dixarit Tab 0.025mg
Catapres-TTS-1
Mint-clonidine
Onyda XR
Clonidine Hydrochloride
Clonidine Transdermal System USP, 0.1 mg/day
Kapvay
Clonidine HYDROCHLORIDE
Jamp Clonidine
Clonidine 0.1
Clonidine HCl Tab 0.2mg
Indication
Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571]
Categories
Adrenergic Agents
Adrenergic Agonists
Adrenergic alpha-1 Receptor Agonists
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Agents producing tachycardia
Agents that produce hypertension
Analgesics
Anesthetics
Anesthetics, General
Antiadrenergic Agents, Centrally Acting
Antiglaucoma Preparations and Miotics
Antihypertensive Agents
Antihypertensive Agents Indicated for Hypertension
Antimigraine Preparations
Autonomic Agents
Bradycardia-Causing Agents
Cardiovascular Agents
Central alpha-2 Adrenergic Agonist
Central Alpha-agonists
Central Nervous System Agents
Central Nervous System Depressants
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A5 Substrates
Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
