DrugBank ID DB00158 ? Name Folic acid Groups approved vet_approved nutraceutical Description Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits.[L5744] In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the body's ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF. There are also several antiepileptic drugs (AEDs) that are associated with reduced serum and red blood cell folate, including [DB00564] (CBZ), [DB00252] (PHT), or barbiturates.[A37004] Folic acid is therefore often provided as supplementation to individuals using these medications, particularly to women of child-bearing age. Inadequate folate levels can result in a number of health concerns including cardiovascular disease, megaloblastic anemias, cognitive deficiencies, and neural tube defects (NTDs). Folic acid is typically supplemented during pregnancy to prevent the development of NTDs and in individuals with alcoholism to prevent the development of neurological disorders, for example. Synonyms Folacin Folic acid Acide folique Pteroyl-L-monoglutamic acid PGA
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid Acidum folicum ¨˘cido f¨Žlico N-pteroyl-L-glutamic acid Fols?ure Pteroylglutamic acid Vitamin M Vitamin B9 Vitamin Bc Folate sodium Folate PteGlu Pteroyl-L-glutamate Pteroyl-L-glutamic acid more Brand Names Av-VITE FB Forte B-complex-50 Tab M-Natal Plus Poly Vi Flor Chewable Tab Se-Natal 19
Nephrocaps Folgard DermaNIC DermacinRx PureFolix Multiple Vitamins and Minerals vitaMedMD One Rx Niaacinamide Azelaic AC TURMER FA B6 Zinc Ox Copper Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA Super Pantoplex Nutri-Tab OB Dr. AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass Keylosa Se-Tan PLUS Folic Acid Injection USP Prenatal PR Natal 430 Right Choice A.M. Multi Formula - Caplet INATAL Ultra Folic Acid Tab 5mg Neonatal DHA Multi Tabs Folvite Tab 5mg WesNatal DHA Complete Multra With Iron Multra Plex TRONVite Vita-B-75 Cap RE FAC-x PRENATE Enhance Tricon Stress B Capsules With Vitamin C Multitabs PrePLUS B-complex 100 P.R.O. 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Away Formula Formula Hh Thrivite Rx Vitafol Fe Plus B6, B12 & Folic Acid Vitamin B + C Cap Chela Potassium Plus Iron Fumarate and Aspartate, Glycinate, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid Balanced B-50 B-complex Vitamins Tab Children's Chewable Multiple Vitamins - Tab Pregvit Folic 4 Body Rox Folite Vita-vim - Tab Twin G.F. Powder Vitasure Stress Complex 600 Avec Vit E Cuivre Zinc Women's Biomultiple Vitamin and Mineral Supplement Multi Enfants Tab Virt-Vite Forte Daily Supplement Packs Super Daily No 2 PreNatal Vitamins Plus Prenatal Plus Vitamins Jenliva Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo Replavite Zyvit B Stress C + Iron & Vite Vital-D Rx Fusion Plus Pro Hers Vanilla PR Natal 400 ec vitaMedMD Rx Plus Stress Formula Multi-B Comp + 500mg Vit C Cap M.V.I. 12 Century Complete UltimateCare ONE NF Complete-RF Prenatal Folic Acid Injection, USP Supplement De Multivitamines Infusion Arome Fruits Rouges Timed Release B-complex 50 NEONATAL Complete Novel Vita Mega 13 Multivitamin Formula Amerix Multivitamin Folet One Kids Stuff With Iron Tablets Spd Tab Vasculine Prenaissance Cavan Folate OB Vitamin B Compound W Vit C 250mg Tab Vita Vim Multivitamins and Minerals Tab Vita Balance 2000 Multivitamins and Minerals for Young Women Ferrex 28 Vtb Vitamin and Mineral Supplement Multinate DHA Extra Multicaps Neonatal Plus Vitamin Virt-Vite Feminique W Iron and Calcium Tab Vege Swiss One Multivitamin W Chel Mins Tab Balanced B-complex Vit + Vit C&e Tab Folvite Inj 5mg/ml Niva-Fol Vitrexyl plus Iron Adult Infuvite Multiple Vitamins Corvite Swical-energy 3e Age TriAdvance Zingiber Balanced B50 Complex Mini-B Tab One Tablet Daily Mens Formula DaVITE Ultimate OB DHA Folic Acid Plus Swiss One Multivitamin and Mineral Caplet Childrens Chewable Vitamins Inatal Advance Oncovite Hypo Vites Tab Children's Vitamins W Iron Chewable Multivitamins and Minerals - Complete FeRivaFA Multivitamin with fluoride Multivitamines Pour Enfants (chewable Tablets) Homosistrox Capsules Cavan Folate DHA Iron Folate-F Vita Vim With Beta Carotene-caplet Hematogen FA Childrens Chewable Multiple Vitamins Tab Formula F L W L.C. 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Complex Folic-K Multivitamines Et Mineraux Reguliers / Regular Multivitamins and Minerals OB Complete Gold Multi-11 One-A-day Advance Men's DuetDHA Balanced Chewable Multivitamins Plus Iron Orifer F Supravite Stress Avec Vit E Vitafol Caplet PureFe Plus Children's Chewable Multivitamin and Multimineral Tricare Prenatal DHA One Rx Multivitamin For-2 Liquid B Complex 50 Super Charged Energy Kid's Choice Children's Chewable Vitamins - Tab Zatean-Pn DHA Liqui B Complex Viva Kids - Tab Reliv So Sense Daily Vitamin Supplement Vitamin B Complex 50 Children's Chewable Multi-vitamin Premium Prenatal - Tablets Children's Chewable Multi Vit W Iron Multi Flow Tablets Avon Vitadvance Multi-kids Complete Nicadan PreferaOB plus DHA Niferex Prenate AM For Kids Only Chewable Multivitamins - Tab Natalvirt 90dha Pregnancy Multivitamin Prenatal Mega Antioxidant Children's Chewable Multi-vitamin Complete With Minerals Vitamin B Complex Suppl Spectrum Performa Multivitamins and Minerals Tablets Multi II IV Vi Tab Prenatal Vitamin and Mineral Supplement -tab Folic Acid 1mg With Vitamin C H.W. 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Adult FeRiva FA Multitam Vitramyn Reno Caps CitraNatal Bloom DHA Durachol DuetDHA Complete Kimchi Vitamin chewable multivitamin Bio-fen PNV Ferrous Fumarate Docusate Folic Acid V & M Vitamin and Mineral Supplement Women's Formula TL-Select DHA Folastin Re Ob 90 DHA Vitafol One NicAzelFORTE Vit-HA Multi Vitamin and Zinc Supplement Prenate Pixie Multi Vitamin with Fluoride Multiple Vitamins - Tablet Prenatal Plus Multivitamin Plus DHA MiniCaps Renate DHA Essential B Tablets Vege 1 Daily Tab Lipo-B-C Tab Select-OB Plus DHA Prenatal Supplement Plus DHA Chew.multiple Vits.with Extra C for Children Udamin Sp Taliva Nicadan ZX Grand Master Formula Tab Daily-Vite CitraNatal Bloom Prenate Chewable RediChew Master Key Multi Vitamin Multi Mineral Formula 2 Mega Plex IV - Pck Vena-Bal DHA Abavite Se-Natal 19 Chewable TL-Icon Kids Stuff Tablets Virt-PN DHA Nutrol-B-complex Ferralet 90 MI-Vite RX Stress Vitamin B With C Complex Tablets Vitamin B Complex Tab OB Complete DHA Childrens Chewable Tab Tricare Prenatal Megavite Rx Neonatal Fe Nicotinamide Vitafol Cavan Prenatal Vitamin B-12 With Folic Acid Tablets Super Vita Vim Multivitamins and Minerals Children's Chewable Multi Vitamins Prenatal Plus PreferaOB Tozal Spark Cap TL-Folate PreferaOB One Vigo Multivitamins Drops/lozenge Children's Chewable Multivitamins With Minerals Folic Acid Capsules 1mg Concept OB Virt-Vite Plus DermacinRx Purefoltin Macuvex Preplus Sodium Polysulthionate and Folic Acid Vital Be-100 Hsn Formula Carbassist Tablets PM Caps PramLyte Av-VITE FB Vitafol Ultra Protect Cardio AF Prenatal and Post Partum Supplement Prenatabs FA WellFola VP CH Plus B-50 Complex Hemetab Stress Formula B-comp + 500mg Vit C Tab Vitazyme 50 Plus Multiple Vitamins & Minerals Folic Acid 1mg With C 20mg Bugs Bunny Chew Multi Vit Plus Iron Edge OB Revitalize Multi-vitamin and Mineral Complex Vinacal Folitin-Z bioJET One A Day Tab Bentivite CitraNatal Assure Dialyvite Supreme D Multi-vitamins With Minerals Trinatal Rx 1 Vitalife - Capsule Pretrate Multiple Vitamins & Minerals Tablets Fib-C Melts Prenavite Forte Multi-phyto Capsules Advanced B & T Formula For Men Multi Vitamin - Mineral Vp-heme Ob DHA Super B Compound W 500mg Vit C Ply Vi Sol Chewable Tab Rocky Mountain Multiple Vit and Min Mega Tab One Daily VITES Hi Potency B52 B Complex Tab Feminex 300 Tab Cedevita Sugar-free Vitamin Supplement B Complex 50+ Caplet Vitaflex Dietary Suplement FaBB PreNatal 19 Tandem DHA OB Complete Prenatal natelle COMPLETE WesCaps Formula D.S. 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Complex PreTAB Folic Acid-b12 Tab TriphroCaps Duet DHA 400 ec Focalgin 90 DHA B-100 Hi Potency B Vitamins Tab Daily Balance Tab Hemocyte Plus Vol-Tab Rx Foliflex Phytopure Daily Energy Brand B-complex B-complex Folic Acid Inj 5mg/ml USP Venexa FE Florafol Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Luna Vitamin and Mineral Bar for Women CitraNatal Harmony 3.0 Ostachol Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA PureFe OB Plus Stress B With 1000 Mg Vitamin C PreQue 10 Super Kids Chewable Multivitamin Multimineral (chewable Tablets) Natalvirt FLT Foltamin Prenavite Forte Tablets Divista Children's Chewable Tab Corvita Central-vite 18 Essential Folvite Adeks Tablets 24 Multivitamins + Minerals Nephron FA NicAzel Tulivite Usana Megavitamin Tablets - Tab Prenatvite Vitamin B6 & B12 With Folic Acid Swiss One Low Potency B Complex Tab Envirocomplex Multivitamin with Fluoride Nicomide NuFera PNV-Select Ultra Hr Chewable Adult Multivitamins With Minerals Florravite Omnivex FeRiva 21 7 Xyzmune Vyo Cylate - Pwr Mag-A-folic Tab BP Vit 3 C-B Complex Multivitamines Et Mineraux Junior Regulier Sulfzix FUSION Sprinkles PaxLyte Iron Se-Natal One Ferotrin Milltrium Senior Vitamin and Mineral Supplement Children's Chewable Multiple Vitamins (chewable Tablets) TL Gard Rx Vp-ggr-B6 Hylavite Balanced B-50 Complex B-100 Vitamin Supplement Folbic NewFolic Pnv-dha Mebolic Multivitamins for Children Great Day/am Formula Tab Vitamin B12 Plus Tablets W Folic Acid Folditam Maintain Multiple Vitamin & Minerals Maximum Once A Day Multinate DHA Foltrate Vita-worth B-complex Tablets Mnps Formula Supplement Animi-3 PRENATE Restore Neonatal19 Spectrum 2 Cap Iron, Vit & Min Supp Ortho D Vitafol Plus Folic Acid 800mcg Tab A/o-26 - Caplet Folic Acid Tablets 5mg T.R.I. 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Complex FolaMax Cardiotek-RX Folic Acid Tab 1mg USP Chewable Prenatal Formula Tab FerroGels Forte Ventrixyl Fe Women's Change Formula Folic Acid Ctr Srt 800mcg B Compound 50mg Tab MagneBind 400 Rx Triveen-Duo DHA VIL-Rx Energy 80 Prolonged Release Tab Multi Vitamin Plus Iron Taron-C DHA Prenatvite Plus Ez-flex Taron-prex Prenatal Prenatal Vi-min Vitafol Nano Advanced AM PM Fizz Multivitamins for Kids W C Loz Vp-pnv-dha Virt Nate Pnv-OB-dha Vit B Complex Ctr Prenate DHA Super Stress Capsules Complete One-A-day - Tab Phytovim Cap Polymine Avec Zinc Et Cuivre Oveeza RenaPlex Dothelle DHA MYNEPHROCAPS DIALYSIS/STRESS Vitamin Supplement Cholecal DF Strovite Forte Caplet Vitaplex Strovite One Caplets Quflora Gummies HemeNatal OB plus DHA Extra Once A Day Nutra-Z Trinaz CompleteNate Chewable Fortamines-10 Comprimes Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets) Essential Vitamins and Minerals Complete Multivitamins and Minerals Tablets Timed Release Folic Acid 1mg Floradix Formula Liq more Indication Folic acid is indicated for the treatment of folic acid deficiency, megaloblastic anemia, and in anemias of nutritional origins, pregnancy, infancy, or childhood. Categories Antianemic Preparations Autacoids BCRP/ABCG2 Substrates Biological Factors Diagnostic Agents
Diet, Food, and Nutrition Dietary Supplements Drugs that are Mainly Renally Excreted Folic Acid and Derivatives Food Growth Substances Hematinics Hematologic Agents Heterocyclic Compounds, Fused-Ring Micronutrients OAT1/SLC22A6 inhibitors Pteridines Pterins Supplements Vitamin B Complex Vitamin B12 and Folic Acid Vitamins more ATC-Code more CAS number 59-30-3