Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Synonyms
Gabapentina
Gabapentin
1-(Aminomethyl)cyclohexaneacetic acid
Gabapentinum
Gabapentine
Gabapentino
Brand Names
Priva-gabapentin
Apo-gabapentin Tablets
Neurontin
Jamp-gabapentin
Innoprax-5
Therapentin-60
Bio-gabapentin
SmartRx Gaba-V Kit
Gralise
Ntp-gabapentin
Sig-gabapentin
Prilopentin
Gln-gabapentin
Gralise Starter Pack
Fanatrex
Cyclo/Gaba 10/300 Pack
Bci Gabapentin
Gabapentin
Mar-gabapentin Tabs
Nu-gabapentin Capsules
Mylan-gabapentin
Lido GB-300
Ipg-gabapentin
Gabarone
Pendo-gabapentin
Gd-gabapentin
Van-gabapentin
Lipritin II
Dipentocaine Topical Cream Compounding Kit
Lipritin
Ag-gabapentin
Pro-gabapentin
Mint-gabapentin
Gaba 300-EZS
Apo-gabapentin
Auro-gabapentin
Teva-gabapentin
SmartRx Gaba Kit
Ran-gabapentin
Riva-gabapentin
PMS-gabapentin
Gapeam Budibac
ACTIVE-PAC with Gabapentin
Auro-gabapentin Tablets
Mar-gabapentin
Gabapentin Kit
Gabapentin Tablets USP
Nra-gabapentin
Gabapentin Capsules USP
Gabapentin Capsules
Jamp Gabapentin Capsules
Lidotin
Taro-gabapentin
Gabacaine
Act Gabapentin
GPL Pak
PHL-gabapentin
Dom-gabapentin
Ratio-gabapentin
Prilopentin -II
Pentican
Jamp-gabapentin Tablets
Gabapal
Therapentin-90
Topical Nerve Pain
Indication
In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.[L8717] In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.[L8732]
Categories
Acids, Acyclic
Acids, Carbocyclic
Amines
Amino Acids
Amino Acids, Peptides, and Proteins
Aminobutyrates
Analgesics
Anti-epileptic Agent
Anticonvulsants
Butyrates
Central Nervous System Agents
Central Nervous System Depressants
Cyclohexanecarboxylic Acids
Cyclohexanes
Cycloparaffins
Decreased Central Nervous System Disorganized Electrical Activity
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
