HCZ

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Created:	2009-08-06
Last modified:	2011-06-04

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4 entries where HCZ is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	25
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	6

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Chemical Component Summary
Name	6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Systematic Name (OpenEye OEToolkits)	6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Formula	C₇ H₈ Cl N₃ O₄ S₂
Molecular Weight	297.739
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	11.02	O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)NCN2)N
SMILES	CACTVS	3.352	N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
SMILES	OpenEye OEToolkits	1.7.0	c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
Canonical SMILES	CACTVS	3.352	N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
Canonical SMILES	OpenEye OEToolkits	1.7.0	c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
InChI	InChI	1.03	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKey	InChI	1.03	JZUFKLXOESDKRF-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00999 ?
Name	Hydrochlorothiazide
Groups	approved vet_approved
Description	Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Synonyms	Hidroclorotiazida Hydrochlorothiazide HCTZ Hydrochlorothiazidum
Brand Names	Mylan-valsartan Hctz Candesartan Cilexetil-Hydrochlorothiazide Moduret PMS-ramipril-hctz Apo-lisinopril/hctz Fosinopril Sodium and Hydrochlorothiazide Atacand HCT Pro-triazide Candesartan Cilexetil and Hydrochlorothiazide Monopril-hct Amturnide Amiloride Hydrochloride and Hydrochlorothiazide Gln-olmesartan Hctz Lisinopril and Hydrochlorothiazide Jamp-losartan Hctz Methyldopa and Hydrochlorothiazide Irbesartan Hydrochlorothiazide Zentiva Hydrochlorothiazide 100 Tab Nu-amilzide 5/50 Mg Tab Nu-triazide Tab 50 Mg/25 mg Novamilor Olmesartan Medoxomil-hydrochlorothiazide Rasilez HCT Valsartan HCT Apo-valsartan/hctz Losartan-hctz Irbesartan HCT Pendo-telmisartan-hctz Enalapril Maleate and Hydrochlorothiazide Teva-olmesartan/hctz Auro-candesartan HCT Ag-irbesartan Hctz Dyazide Ifirmacombi Truemed Group LLC Teva-lisinopril/hctz (type Z) Lisinopril and hydrochlorothiazide Auro-losartan HCT Inderide-40 Tab Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg Ag-olmesartan Hctz Losartan Potassium HCTZ Quinapril and Hydrochlorothiazide 20/25 Jamp Quinapril / Hctz Maxzide Mylan-telmisartan Hctz Viskazide Diovan HCT Apo Methazide 25 Telmisartan Hctz Jamp Telmisartan-hct Neo Codema 25mg Nra-olmesartan Hctz Sandoz Candesartan Plus Candesartan HCT Hydrochlorothiazide Tablets 50mg Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg PMS-olmesartan-hctz Inhibace Plus Inderide Aldoril 25 Tab Teva-losartan/hctz Neo Codema 50mg Metoprolol Succinate and Hydrochlorothiazide Novo-valsartan/hctz Mylan-irbesartan Hctz Pritorplus Taro-ramipril Hctz Mylan-lisinopril Hctz Act Telmisartan/hct Microzide Olmesartan/hctz Lisinopril and Hydrochlorthiazide Penta-triamterene Hctz Tablets Karvezide Ag-losartan Hctz Teva-irbesartan Hctz Bio-hydrochlorothiazide Ag-candesartan HCT PMS-telmisartan-hctz Teva-candesartan/hctz Propranolol Hydrochloride and Hydrochlorothiazide Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg Q-valsartan Hctz Mylan-candesartan Hctz Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg Dyazide Tab Candesartan/hctz Ran-irbesartan Hctz Teva-valsartan/hctz Sandoz Lisinopril HCT Van-irbesartan-hctz Tolucombi Irbesartan/hct Apo-telmisartan/hctz Quinapril and Hydrochlorothiazide 20/12.5 PHL-hydrochlorothiazide Ag Telmisartan-hct Losartan Potassium and Hydrochlorothiazide Ava-hydrochlorothiazide Teva-hydrochlorothiazide Quinapril Hydrochloride/Hydrochlorothiazide Apo Methazide 15 Apo-candesartan/hctz Penta-amiloride Hctz Tablets Apo-quinapril / Hctz Tablets Teva-quinapril/hctz Irbesartan Hydrochlorothiazide Bms Ntp-telmisartan Hctz Hydrochlorothiazide Hydralazine HCl and Hydrochlorothiazide Nra-candesartan Hctz Taro-telmisartan Hctz OLMESARTAN MEDOXOMIL and HYDROCHLOROTHIAZIDE Teva-irbesartan/hctz Apo-irbesartan/hctz Aldoril 15 Tab Benicar Hct Ser-AP-ES Tab Losartan/hctz Van-telmisartan-hctz Hyzaar Irbesartan / Hydrochlorothiazide Teva Hydrochlorothiazide 25mg Tablets Losartan HCT DS Auro-valsartan HCT Uniretic Lopressor HCT Diovan-hct Bisoprolol Fumarate and Hydrochlorothiazide Aa-amilzide Accel-candesartan/hctz Olmesartan Medoxomil / Hydrochlorothiazide Hydrochlorothiazide 50 Apo-olmesartan/hctz Novo-doparil 15 Tab Quinapril Hydrochloride and Hydrochlorothiazide Losartan Pot/hctz Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide Alti-amiloride Hctz Amlodipine, Valsartan and Hydrochlorothiazide Dom-hydrochlorothiazide Teva-cilazapril/hctz Pendo-irbesartan-hctz Van-losartan-hctz Metoprolol Tartrate and Hydrochlorothiazide 100 mg-50 mg Ntp-hydrochlorothiazide Dutoprol Tekturna HCT Maxzide-25 PMS-dopazide 15 Tab Mint-irbesartan/hctz Irbesartan/hydrochlorothiazide Teva Gd-quinapril Hctz Ntp-irbesartan/hctz Ziac Aldactazide 50 Nu-hydro Ach-telmisartan Hctz Nra-telmisartan/hctz Sandoz Olmesartan Hctz PMS-valsartan-hctz Bisoprolol Fumarate Hydrochlorothiazide Hydrochlorothiazide Tab 25mg PMS-dopazide-25 Tab Aldactazide Hydrochlorothiazide Tablets 25mg Metoprolol Tartrate and Hydrochlorothiazide Valsartan/htcz Mar-candesartan / Hctz Teva-telmisartan Hctz Candesartan-hctz Auro-telmisartan Hctz Auro-irbesartan HCT Prinzide Altace HCT Hydropres 25 Tab Mint-hydrochlorothiazide Olmetec Plus Losartan/hct Quinapril Hydrochloride/hydrochlorothiazide Novo-doparil 25 Tab Micardisplus PMS-irbesartan-hctz Sandoz Valsartan HCT Hydrodiuril Tab 100mg LOSARTAN POTASSIUM and HYDROCHLOROTHIAZIDE Auro-quinapril Hctz Valsartan-hctz Valsartan HCTZ Hydrochlorothiazide Tab 50mg Zestoretic Hydrodiuril Tab 25mg Accuretic Jamp-irbesartan and Hydrochlorothiazide Hydrodiuril Tab 50mg Aldoril Enalapril maleate and hydrochlorothiazide Mylan-amilazide PMS-hydrochlorothiazide Hyzaar DS Riva-zide 50/25mg Tablets Act Losartan/hct PMS-losartan-hctz Sandoz Irbesartan HCT Candesartan Cilexetil and Hydrochlorothiazide Tablets Captopril and Hydrochlorothiazide Apo-spirozide Tab Nu-lisinopril/hctz Apo Triazide Act Candesartan/hct Kinzalkomb TELMISARTAN and HYDROCHLOROTHIAZIDE Amlodipine, Valsartan, Hydrochlorothiazide Micardis HCT Prz-olmesartan/hctz Apo-hydrochlorothiazide Aldactazide 25 Teva-lisinopril/hctz (type P) Olmesartan Medoxomil and Hydrochlorothiazide Triamterene and Hydrochlorothiazide Hydrochlorothiazide 100mg Tablets Sandoz Telmisartan HCT Telmisartan/hctz Irbesartan and Hydrochlorothiazide Telmisartan and Hydrochlorothiazide Avalide Riva-amilzide 5/50 mg Moexipril hydrochloride/hydrochlorothiazide Valsartan and hydrochlorothiazide Lisinopril/HCTZ Quinapril and Hydrochlorothiazide Valsartan and Hydrochlorothiazide Benicar HCT Teva-olmesartan / Hctz Losartan potassium and hydrochlorothiazide Vaseretic Esidrix Quinaretic Apo-ramipril/hctz Diuchlor H Tab 50mg Metoprolol Tartrate and Hydrochlorothiazide 100 mg-25 mg Septa-candesartan Hctz Timolide Tab Urozide Imprida HCT Ratio-losartan Hctz Losartan potassium and Hydrochlorothiazide Quinapril HCL and Hydrochlorothiazide Ramipril-hctz Copalia HCT Benazepril hydrochloride and hydrochlorothiazide Capozide Alembic-telmisartan/hctz Apo-quinapril/hctz Lotensin HCT Mylan-losartan Hctz Teveten Plus Benazepril Hydrochloride and Hydrochlorothiazide Enalapril/hctz Triamterene hydrochlorothiazide Enalapril Maleate/hctz Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg Exforge HCT Inderide-80 Tab Hydrochlorothiazide 50mg Tablets Ser-Ap-Es Sandoz Losartan HCT PMS-candesartan-hctz Telmisartan-hctz Apo-cilazapril/hctz Mint-losartan/hctz DS Lisnopril/hctz (type P) Metoprolol Tartrate and Hydrochlorothiazide 50 mg-25 mg Losartan HCT Coaprovel Benazepril and Hydrochlorothiazide Micardis Plus Teva-spironolactone/hctz Apo-losartan/hctz Ntp-lisinopril/hctz (type P) Amlodipine, Valsartan, and Hydrochlorothiazide Dafiro HCT Zinda-candesartan/hydrochlorothiazide Jamp Candesartan-hct Ntp-lisinopril/hctz (type Z) Lisinopril with Hydrochlorothiazide Septa-losartan Hctz Act Irbesartan/hct Hydropres 50 Tab Moexipril Hydrochloride and Hydrochlorothiazide Tribenzor Quinapril and Hydrochlorothiazide 10/12.5 Lisinopril/hctz (type Z) Ami-hydro Tab Sandoz Losartan HCT DS Irbesartan-hctz Olmesartan Medoxmil and Hydrochlorothiazide Dom-irbesartan-hctz Auro-olmesartan Hctz Olmesartan Medoxomil/hctz Ava-lisinopril HCT Spironolactone and Hydrochlorothiazide Teveten HCT Mint-losartan/hctz Ava-valsartan HCT Telmisartan and Hydrochlorthiazide Teva-ramipril/hctz Ach-olmesartan Hctz Actelsar HCT Jamp-olmesartan Hctz Irbesartan/hctz Ava-irbesartan/hctz Teva-triamterene/hctz Atacand Plus Teva-enalapril/hctz
Indication	Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450,L45663]
Categories	Amides Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Benzothiadiazines Cardiovascular Agents Diuretics Drugs causing inadvertant photosensitivity Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Heterocyclic Compounds, Fused-Ring Hyperglycemia-Associated Agents Hypotensive Agents Increased Diuresis Low-Ceiling Diuretics and Potassium-Sparing Agents Membrane Transport Modulators Natriuretic Agents Nephrotoxic agents Non Potassium Sparing Diuretics OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Substrates Photosensitizing Agents Potential QTc-Prolonging Agents QTc Prolonging Agents Sodium Chloride Symporter Inhibitors Sulfonamides Sulfones Sulfur Compounds Thiazides
ATC-Code	C09BX03 C03AX01 C03AB03 C09DX03 C03EA01 C09DX06 C09XA52 G01AE10 C09DX01 C03AA03 C09XA54 C09DX08 C09DX07
CAS number	58-93-5

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Solute carrier family 12 member 3	MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSST...	unknown	inhibitor
Angiotensin-converting enzyme	MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFA...	unknown	modulator
Calcium-activated potassium channel subunit alpha-1	MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS...	unknown	inhibitor
Albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	substrate,inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
Solute carrier family 22 member 11	MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCW...	unknown	substrate
ATP-binding cassette sub-family C member 4	MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPE...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL435
PubChem	3639
ChEMBL	CHEMBL435
ChEBI	CHEBI:5778
CCDC/CSD	KASMOH, HCSBTZ01, HCSBTZ02, LOLZOE, HCSBTZ08, DADNEE, PIRYAS, HCSBTZ04, DADMUT, HCSBTZ05, CASCAB, NOLCAV, LOLZEU, CASMAL, PIRXUL, EGENIP02, MUPPIX, HCSBTZ03, NOLCEZ, PIRXOF, HCSBTZ06, HCSBTZ07, ODATIX, ODEFEJ, VITWIE, BANPAK, PIRLUZ, EGENOV, SIZZUZ, DADMED, DADMIH, EGENIP, DADMED01, EGENIP01, DADNAA, HCSBTZ, EGENUB, NOLBOI, NOLBOI01, SOBBAP, REZXEZ, EGEPAJ, OBAFIK, HCSBTZ09
COD	2211088, 2206412, 2206455, 2206674, 2206702, 2103079, 4502543, 7216244, 7216241, 7217346, 7217349, 2105753, 2105754, 2105755, 2105756, 2208938, 2209149, 1551861, 1551862, 1551863, 1551864