IPH

PHENOL

Created:	1999-07-08
Last modified:	2011-06-04

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114 entries where IPH is found as a standalone ligand3 entries where IPH is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	13
Chiral Atom Count	0
Bond Count	13
Aromatic Bond Count	6

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Chemical Component Summary
Name	PHENOL
Systematic Name (OpenEye OEToolkits)	phenol
Formula	C₆ H₆ O
Molecular Weight	94.111
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Oc1ccccc1
SMILES	CACTVS	3.341	Oc1ccccc1
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)O
Canonical SMILES	CACTVS	3.341	Oc1ccccc1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)O
InChI	InChI	1.03	InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
InChIKey	InChI	1.03	ISWSIDIOOBJBQZ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB03255 ?
Name	Phenol
Groups	experimental approved
Description	Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Phenol is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract.
Synonyms	Fenol PHOH Phenyl alcohol Acide carbolique Phenylic acid Phenyl hydroxide Acide phénique Monohydroxybenzene Phenic Acid Benzenol Carbolic acid Oxybenzene Carbols?ure Phenylic alcohol Phenol Karbols?ure Hydroxybenzene
Brand Names	ABSORBINE jr. Rugby Cherry Flavor ZYCAZIN Antiseptic Liquid Poison Oak and Ivy Sunmark Sore Throat First Aid Throat Relief Phylorinol Anbesol Maximum Strength Liquid Chloraseptic Sore Throat Max NICE SORE THROAT Cherry Chloraseptic Sore Throat (Kids Grape) Grape ChapIce Camphor Phenol Gel Fortinia ID Labisan Castellani Paint 1.5% Kank-A with Blistex Medicated Lip Shopko Camphor Phenol Gel Absorbine Jr Pro Cream Poison Oak Sting Eze Phenaseptic Cherry PUBLIX Sore Throat Fast Relief Oral Anesthetic Calamine Phenolated Topical Suspension Sore Throat Aseptil Rojo Medicated Lip Balm Sore Throat Menthol Absorbine Jr Pro No Mess Roll-on Plus Ulcerease NICE SORE THROAT Honey Lemon Diluent Sterile Blistex Dct Lip Conditioner Lip Balm Sunmark sore throat Major Camphor and Phenol HEB Sore Throat Menthol Flavor Leader Camphor Phenol Gel Phenol 6% Phenol Medicated Lipbalm Chapstick Medicated Lip Balm - Tube NICE SORE THROAT Spearmint Sunmark Phenolated Calamine OFF Bite and Itch Relief First Aid Antiseptic Chapstick Medicated Lip Balm - Jar Walgreens Sore Throat Cherry Flavor Balzarol Ont Castellani Paint CVS Health Sore Throat Fast Relief Oral Anesthetic Equate Sore Throat Sore Throat Relief Cherry Sting Kure - Liq Bite and Sting Relief Stick Phen-oris - Ont Top Ambix First Aid CAMPHOR (SYNTHETIC) and PHENOL Glycerinated Phenol Saline Phenol Saline Inj Campho-Phenique Pain Relieving Antiseptic Liquid Campho Phenique Cold Sore Treatment Chloraseptic Warming Sore Throat Carmex Lip Ointment Campho-Phenique Antiseptic DDM Instant Antiseptic Pain Relief Liver supplement Sore Throat Cherry Medicated Blistex Dct Lip Balm Phenoris Ont Blistex Medicated Blistex Medicated Variety Pack (Blistex Medicated Berry Lip Balm, Blistex Medicated Lip Balm, Blistex Medicated Lip) Preferred Plus Medicated Lip Balm StingEze Insect Bite Relief Chloraseptic Sore Throat Citrus Ozonol Ont Cepastat Extra Strength Cepastat Cherry Sore Throat Relief Menthol Good Neighbor Pharmacy Sore Throat HEB Sore Throat Cherry Flavor Sting-eze-liq Anbesol Liquid MAKESENSE First Aid Meijer Sore Throat Banana Boat Medicated Lip Balm CVS Health Maximum Strength Sore Throat Fast Relief Leader Sore throat Maximum Strength Cold Sore Treatment Sore Throat Relief Smart Sense Sore Throat Campho-Phenique Cold Sore Treatment Leader Sore Throat Dermagesic eos Medicated Pain Relieving Lip Balm Blistex Lip Medex Cold Sore Treatment Healthy Accents Sore Throat StingEze Max Insect Bite Relief Walgreens Camphor Phenol Gel Sore Throat Relief Cherry Flavor Natur 911 Blistex con Medicacion Crema Labial Vida Mia Instant Antiseptic Pain Relief Wild Horse 777 Oral Exchange Select Cold Sore Treatment Blistex Lip Budpak First Aid Mecca Ointment Bite Relief Equaline Sore Throat Good Neighbor Sore Throat Cherry Flavor Boil Ease Drawing Salve Ont Signature Care Maximum Strength Cold Sore Treatment Anbesol Gel Vaseline Brand Lip Therapy Medicated Tube CareOne Cold Sore Treatment Chloraseptic Sore Throat Menthol Blistex Complete Care (Blistex Lip Medex, Blistex Medicated Lip, Blistex Five Star Lip Protection Broad Spectrum, and Blistex Complete Moisture) Care One Sore Throat Instant Antiseptic Pain Relief Sore Throat ReadyInCase Abridge Cold Sore Treatment Pain A Lay Dg Health Sore Throat ChigaRid CAMPHO-PHENIQUE ANTISEPTIC Gel Chloraseptic Sore Throat Cherry Topcare Sore Throat Chloraseptic Sore Throat Vicks Formula 44 Sore Throat meijer Maximum Strength Sore Throat Fast Relief Labisan Cold Sore BiteMD External Analgesic First Aid Antiseptic Chigarid CVS Camphor Phenol Gel DRx Choice Sore Throat Menthol Flavor PUBLIX Sore Throat Menthol Flavor Rx Act Sore Throat Topcare Sore Throat Menthol Flavor Carmex Lip Balm Sterile Diluent for Allergenic Extract Good Sense Sore Throat Yat Tip Xiao ABC Sore Throat Menthol Flavor HEB Camphor Phenol Premier Value Instant Antiseptic Pain Relief Pain Relieving Petro Carbo Chapstick Medicated Sore throat cherry Topcare Cold Sore Treatment Blistex Medicated Lip Balm Variety Pack (Blistex Medicated Berry Lip Balm, Blistex Medicated Lip Balm, Blistex Medicated Lip) Vortex Moisturizer Oral Dermaphy Ont Diluent for Allergenic Extract Sterile Normal Saline With Phenol (0.4%) Oral Relief Coghlan s Sting Relief Au Kah Chuen Skin Lotion Freds Antiseptic Instant Pain Relief Chapstick Medicated Lip Balm - Stk TopCare Cherry Flavor
Indication	Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity.
Categories	Anesthetics Anesthetics, Local Anti-Infective Agents Anti-Infective Agents, Local Antiseptics and Disinfectants Antivaricose Therapy Benzene Derivatives Cardiovascular Agents Compounds used in a research, industrial, or household setting Dermatologicals Disinfectants Miscellaneous Therapeutic Agents Nervous System Pharmaceutical Preparations Pharmaceutical Solutions Phenol and Derivatives Phenols Sclerosing Agents for Local Injection Sclerosing Solutions Solutions Throat Preparations Vasoprotectives
ATC-Code	C05BB05 R02AA19 N01BX03 D08AE03
CAS number	108-95-2

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Carbonic anhydrase 1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV...	unknown	inhibitor
Carbonic anhydrase 4	MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDR...	unknown	inhibitor
Carbonic anhydrase 12	MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSC...	unknown	inhibitor
Carbonic anhydrase 2	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...	unknown	inhibitor
Carbonic anhydrase 14	MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDI...	unknown	inhibitor
Carbonic anhydrase 9	MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLG...	unknown	inhibitor
Albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown
Thermolysin	MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLL...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	996, 20488062
ChEMBL	CHEMBL14060
ChEBI	CHEBI:15882
CCDC/CSD	AGOKEN, JIMRON, DEVXOS, JUCYAH, AGOTEV, DIKSAS, FOTBAR, FOTBAR10, JECJAC, EBILOR, LAWWOW, EREKAN, JECHUU, LUNCAB, GOKPAA, CAFVOW, FAJYOF, GOKPAA01, HIBFON, FINPUN, HIBFED, DILSOI, ISEKAS, OLAQAT, MARCIT, BOPDAO, LASXUY, HIBFIH, LODLIB, FORQUB, MITGEB, MPPZPO, GIXNOQ, COHWOL, CUXMOA, KACKOS, AZEZEN
COD	2103472