LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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183 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 225,353 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank ID	DB00123 ?
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	LYS Lysine L-Lysine Lysine hydrochloride (S)-lysine Lysine monohydrate L-lys L-2,6-Diaminocaproic acid (S)-2,6-diaminohexanoic acid Lysina 6-ammonio-L-norleucine Lysinum L-Lysin Lysine dihydrate Lysine acid (S)-α,ε-diaminocaproic acid Lysine acetate
Brand Names	Olimel 7.6% E Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Smofkabiven Travasol Amino Acid Inj 5.5% Effervescent Potassium Chloride Essepna TrophAmine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Travasol Inj Without Electrolytes 5.5% Hepatasol Olimel 4.4% E Nephramine Liq IV Aminosyn RF Injection Aminosyn II 10% With Electrolytes RenAmin Vamin N Clinimix E Aminosyn 7% Travasol E 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Clinimix 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Nutrineal Pd4 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn 10% W Electrolytes Imubolic Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Synthamin Xyzmune Aminosyn II with Electrolytes in Dextrose with Calcium Smofkabiven Peripheral Olimel 3.3% E Olimel 5.7% Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. FreAmine III ProSol 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Smofkabiven Electrolyte Free Aminosyn II 8.5% Injection 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Aminosyn-PF 10% Travasol Amino Acid Inj 8.5% NephrAmine Novamine 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Periolimel 2.5% E Plenamine Perikabiven 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn Sulfite Free Aminosyn-PF 7% 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II 7% Injection Kabiven Primene 10%-liq IV Travasol Aminosyn 8.5% Injection With Electrolytes Olimel 5.7% E Premasol - sulfite-free (Amino Acid) Aminosyn HF Aminosyn-PF Lysakare 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Aminosyn 3.5% M 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Smofkabiven Extra Nitrogen Electrolyte Free Travasol Inj Without Electrolytes 8.5% HepatAmine FreAmine HBC 20% Prosol 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Smofkabiven Extra Nitrogen 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Olimel 4.4% Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Aminosyn II In Dextrose Injection Renamin (amino Acids) Injection Primene 10% Aminosyn 8.5% Olimel 7.6% Aminosyn 5% 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose 8.5% Freamine III 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn II 7% With 10% Dextrose Aminosyn II and Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II in Dextrose Aminosyn RF Aminosyn II Aminosyn II 8.5% With 50% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Vamin 18 Electrolyte-free Primene Aminosyn II with Electrolytes Aminosyn II 5% Inj ProcalAmine Aminosyn II 7% With 50% Dextrose 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Clinisol Aminosyn
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682