LYS

LYSINE

Created:	1999-07-08
Last modified:	2024-09-27

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181 entries where LYS is found as a standalone ligand67 entries where LYS is covalently linked to polymer or other heterogen groups 222,671 entries where LYS is found in a polymer sequence

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Chemical Details
Formal Charge	1
Atom Count	25
Chiral Atom Count	1
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	LYSINE
Systematic Name (OpenEye OEToolkits)	[(5S)-5-amino-6-hydroxy-6-oxo-hexyl]azanium
Formula	C₆ H₁₅ N₂ O₂
Molecular Weight	147.195
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CCCC[NH3+]
SMILES	CACTVS	3.341	N[CH](CCCC[NH3+])C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCCC[NH3+])C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC[NH3+])C[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKey	InChI	1.03	KDXKERNSBIXSRK-YFKPBYRVSA-O

Drug Info: DrugBank

DrugBank ID	DB00123 ?
Name	Lysine
Groups	nutraceutical approved
Description	Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Synonyms	(S)-α,ε-diaminocaproic acid LYS Lysine dihydrate Lysinum Lysine Lysine monohydrate Lysina Lysine hydrochloride L-lys (S)-lysine L-Lysin L-Lysine 6-ammonio-L-norleucine L-2,6-Diaminocaproic acid Lysine acetate (S)-2,6-diaminohexanoic acid Lysine acid
Brand Names	Aminosyn RF Olimel 4.4% E Clinimix E Aminosyn Travasol Amino Acid Inj 5.5% Aminosyn 8.5% Injection With Electrolytes 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II 5% Inj 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Xyzmune Travasol Amino Acid Inj 8.5% HepatAmine Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix FreAmine III Nephramine Liq IV Aminosyn II 7% Injection Aminosyn-PF 7% Aminosyn II 7% With 10% Dextrose Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Aminosyn 10% W Electrolytes 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn 3.5% M Aminosyn II 7% With 50% Dextrose Aminosyn HF Aminosyn 8.5% Essepna 20% Prosol 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Hepatasol NephrAmine Aminosyn II 8.5% Injection 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 10% With Electrolytes Kabiven 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix RenAmin Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Vamin 18 Electrolyte-free 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn Sulfite Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Nutrineal Pd4 Aminosyn II In Dextrose Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) FreAmine HBC Travasol Inj Without Electrolytes 8.5% Clinisol Smofkabiven Electrolyte Free Travasol Olimel 3.3% E 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Smofkabiven 4.25%travasol Amino Acid InJ.W.elecw.5%dex. 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Primene 10% Aminosyn II in Dextrose Travasol E Aminosyn II 7% M In 10% Dextrose(dual Chamber) Vamin N Premasol - sulfite-free (Amino Acid) ProcalAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Aminosyn-PF 10% Aminosyn-PF Aminosyn II and Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Olimel 4.4% Imubolic Primene 10%-liq IV Olimel 7.6% E Periolimel 2.5% E Olimel 7.6% Smofkabiven Extra Nitrogen Olimel 5.7% Effervescent Potassium Chloride 8.5% Freamine III Primene Synthamin Aminosyn II Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn RF Injection Olimel 5.7% E 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Lysakare Plenamine Aminosyn II with Electrolytes 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Aminosyn 7% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose TrophAmine Novamine 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn 5% ProSol Renamin (amino Acids) Injection Perikabiven Travasol Inj Without Electrolytes 5.5%
Indication	Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Categories	Amino Acids Amino Acids, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids, Peptides, and Proteins Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Detoxifying Agents for Antineoplastic Treatment Dietary Supplements I.V. Solution Additives Lysine Proteinogenic Amino Acids Supplements
ATC-Code	V03AF11 B05XB03
CAS number	56-87-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
High affinity cationic amino acid transporter 1	MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 4	MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGM...	unknown
Cationic amino acid transporter 3	MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGV...	unknown
Cationic amino acid transporter 2	MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGA...	unknown
Lysine--tRNA ligase	MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQ...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682