SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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110 entries where SER is found as a standalone ligand50 entries where SER is covalently linked to polymer or other heterogen groups 222,921 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank ID	DB00133 ?
Name	Serine
Groups	investigational nutraceutical
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Ser Serina L-Serine beta-Hydroxyalanine Serinum Serine (S)-Serine alpha-Amino-beta-hydroxypropionic acid (S)-2-Amino-3-hydroxypropanoic acid
Brand Names	Aminosyn II 5% Inj 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose FreAmine III Aminosyn II 7% Injection FreAmine HBC Aminosyn 7% Aminosyn 10% W Electrolytes Vamin 18 Electrolyte-free Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 7.6% E Hepatasol ProSol 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn II in Dextrose HepatAmine Aminosyn 8.5% Aminosyn II and Dextrose Essepna 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Aminosyn II Periolimel 2.5% E Aminosyn 3.5% M 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Olimel 5.7% E Primene Novamine Aminosyn II 10% With Electrolytes Aminosyn II with Electrolytes in Dextrose with Calcium Plenamine Olimel 4.4% E Vamin N TrophAmine 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 3.3% E Primene 10%-liq IV Synthamin Smofkabiven Electrolyte Free Aminosyn-PF 10% Aminosyn Sulfite Free Olimel 7.6% Primene 10% ProcalAmine Clinimix E Smofkabiven 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose 8.5% Freamine III Olimel 5.7% 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Kabiven Clinimix 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose RenAmin Perikabiven 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Travasol 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Aminosyn 8.5% Injection With Electrolytes Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II In Dextrose Injection Aminosyn-PF 20% Prosol Smofkabiven Extra Nitrogen Aminosyn HF Aminosyn Nutrineal Pd4 Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn 5% Smofkabiven Peripheral Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn II 8.5% With 50% Dextrose Aminosyn II 7% With 50% Dextrose Olimel 4.4% Aminosyn II 7% With 10% Dextrose Aminosyn-PF 7% Premasol - sulfite-free (Amino Acid) Aminosyn II with Electrolytes 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Clinisol Aminosyn II 8.5% Injection
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01