SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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112 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 227,876 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133 ?
Name	Serine
Groups	nutraceutical investigational
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	(S)-2-Amino-3-hydroxypropanoic acid L-Serine Serinum alpha-Amino-beta-hydroxypropionic acid (S)-Serine Ser Serina Serine beta-Hydroxyalanine
Brand Names	Smofkabiven Extra Nitrogen Aminosyn II 7% With 50% Dextrose Aminosyn II 7% With 10% Dextrose Aminosyn II and Dextrose Periolimel 2.5% E Novamine Aminosyn-PF 10% Aminosyn 5% 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Primene 10%-liq IV Aminosyn-PF 7% Aminosyn-PF Olimel 4.4% E ProcalAmine ProSol Smofkabiven Peripheral Plenamine Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 5.7% E RenAmin FreAmine III 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn HF Synthamin Perikabiven Aminosyn II 8.5% With 50% Dextrose Vamin 18 Electrolyte-free Nutrineal Pd4 Smofkabiven Electrolyte Free Aminosyn 10% W Electrolytes Aminosyn II in Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Olimel 7.6% Primene 10% 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Olimel 7.6% E Aminosyn Sulfite Free Renamin (amino Acids) Injection Aminosyn Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn 7% Olimel 4.4% Aminosyn II 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Primene TrophAmine HepatAmine Olimel 3.3% E Clinimix E 8.5% Freamine III 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Smofkabiven Extra Nitrogen Electrolyte Free 20% Prosol 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn II 5% Inj Aminosyn II with Electrolytes Aminosyn 8.5% Injection With Electrolytes Travasol Aminosyn II 7% M In 10% Dextrose(dual Chamber) Essepna Aminosyn 8.5% Aminosyn 3.5% M Vamin N 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn II 7% Injection Premasol - sulfite-free (Amino Acid) Clinisol Clinimix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Hepatasol Kabiven Aminosyn II In Dextrose Injection Aminosyn II 8.5% Injection 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II 10% With Electrolytes Smofkabiven FreAmine HBC 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Olimel 5.7%
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6857581, 5951
ChEMBL	CHEMBL11298
ChEBI	CHEBI:17115, CHEBI:33384
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01