SER

SERINE

Created:	1999-07-08
Last modified:	2024-09-27

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111 entries where SER is found as a standalone ligand51 entries where SER is covalently linked to polymer or other heterogen groups 226,005 entries where SER is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	1
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SERINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-3-hydroxy-propanoic acid
Formula	C₃ H₇ N O₃
Molecular Weight	105.093
Type	L-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)CO
SMILES	CACTVS	3.341	N[CH](CO)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(C(C(=O)O)N)O
Canonical SMILES	CACTVS	3.341	N[C@@H](CO)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H](C(=O)O)N)O
InChI	InChI	1.03	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	InChI	1.03	MTCFGRXMJLQNBG-REOHCLBHSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00133 ?
Name	Serine
Groups	investigational nutraceutical
Description	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Synonyms	Serinum Serina beta-Hydroxyalanine alpha-Amino-beta-hydroxypropionic acid (S)-Serine L-Serine Ser Serine (S)-2-Amino-3-hydroxypropanoic acid
Brand Names	8.5% Freamine III TrophAmine Aminosyn 10% W Electrolytes Aminosyn II 7% M In 10% Dextrose(dual Chamber) Renamin (amino Acids) Injection ProcalAmine 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose Aminosyn Sulfite Free 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn II 8.5% Injection Aminosyn II In Dextrose Injection Clinimix Primene Aminosyn-PF 10% Smofkabiven Electrolyte Free Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Olimel 4.4% E Essepna Clinimix E 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II 7% Injection Olimel 4.4% FreAmine HBC Smofkabiven Peripheral Aminosyn HF 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn II Periolimel 2.5% E Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Smofkabiven Primene 10%-liq IV 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Smofkabiven Extra Nitrogen Aminosyn 5% Kabiven Novamine Olimel 5.7% Travasol Aminosyn 7% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Perikabiven 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Primene 10% Hepatasol Aminosyn II 7% With 50% Dextrose Olimel 5.7% E Aminosyn II 7% With 10% Dextrose Aminosyn II 8.5% With 50% Dextrose Olimel 3.3% E 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Premasol - sulfite-free (Amino Acid) 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Aminosyn 8.5% Injection With Electrolytes Clinisol Olimel 7.6% E Aminosyn II with Electrolytes in Dextrose with Calcium RenAmin Aminosyn II and Dextrose HepatAmine Olimel 7.6% Aminosyn II 10% With Electrolytes ProSol 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 2.75% Travas. Amino Acid InJ.W.elecw.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn 8.5% Nutrineal Pd4 Synthamin 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn Aminosyn 3.5% M 20% Prosol Aminosyn II with Electrolytes Vamin 18 Electrolyte-free Aminosyn-PF 7% Aminosyn II 5% Inj Vamin N 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Smofkabiven Extra Nitrogen Electrolyte Free Aminosyn-PF Plenamine FreAmine III 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Aminosyn II in Dextrose
Indication	Used as a natural moisturizing agent in some cosmetics and skin care products.
Categories	Amino Acids Amino Acids, Neutral Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	56-45-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Cystathionine beta-synthase	MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPS...	unknown
L-serine dehydratase/L-threonine deaminase	MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCK...	unknown
Serine racemase	MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQ...	unknown
Serine palmitoyltransferase 2	MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQ...	unknown
Serine palmitoyltransferase 1	MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERS...	unknown
Serine--tRNA ligase, cytoplasmic	MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRA...	unknown
Alanine--glyoxylate aminotransferase	MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMS...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	5951, 6857581
ChEMBL	CHEMBL11298
ChEBI	CHEBI:33384, CHEBI:17115
CCDC/CSD	ZIXBOA, AYACUZ, NELRAX, RIWKUD01, DLSERN34, YIGLUX, DLSERN12, XENXUL02, TIXGOW, MIFQUN05, MIFQUN04, MIFQUN06, EYOQOY, MIFQUN07, MIFQUN08, MIFQUN03, VOKHEJ, MIFQUN02, JEJVEA, MIFQUN10, MIFQUN, XATVUK, REZPET, AJODUA, MIFQUN09, JEJVAW, REZPAP, BUTBOJ, GUQBUR, AJODOU, KERMID, XENXUL01, XENXUL, TACPAS, PAZCUO01