Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Nitroglycerol
Nitroglycerine
Glycerin trinitrate
Nitroglicerina
Propane-1,2,3-triyl trinitrate
Trinitroglycerol
1,2,3-propanetrioltrinitrate
NG
1,2,3-propanetriyl nitrate
Glyceroli trinitratis
Glycerol trinitrate
Nitroglycerin
Trinitrine
Glyceroltrinitrat
Glycerol, nitric acid triester
Nitromed
Trinitroglycerin
Glyceryl trinitrate
Brand Names
Nitrogard-SR Tab 1mg
Nitro-dur 0.2
Nitroglycerin Injection USP
Tridil Injection 5mg/ml
Nitrol
Mylan-nitro Sublingual Spray
Apo-nitroglycerin
Nitro-bid
Nitroglycerin Slocaps
Nitroglycerin Transdermal Infusion System
Mylan-nitro Patch 0.8
Nitronal
NitroMist
Transderm-nitro 0.6
Nitroject Inj 1mg/ml
Nitro-Time
Transderm-nitro 0.8
Nitrolingual Pumpspray
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitrong SR Srt 2.6mg
Nitrostat
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Trinipatch 0.6
Nitroglycerin SR
Trinipatch 0.2
Minitran
Nitrolingual
Nitrolingual Spray 0.4mg/eam
Mylan-nitro Patch 0.4
Nitroglycerin Transdermal System
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitro-dur
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitroglycerin In Dextrose
Gonitro
Nitroglycerin ER
Nitro-dur 0.6
Basic Dental Emergency Kit
Trinipatch 0.4
Nitroglycerin in Dextrose
Nitroglycerin Lingual
Mylan-nitro Patch 0.6
Transderm-nitro 0.2
Transderm-nitro 0.4
Transderm Nitro
Nitroglycerin
Mylan-nitro Patch 0.2
Nitroject
Nitro-dur 0.8
Deluxe Dental Emergency Kit
Nitroglycerin Inj 5mg/ml
Rho-nitro Pumpspray
Nitro-dur 0.4
Nitro-time
Rectiv
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitroglycerin Transdermal Delivery System
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (¦Â)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
