VD3

(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL

Created:	2006-06-15
Last modified:	2020-06-05

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Chemical Details
Formal Charge	0
Atom Count	72
Chiral Atom Count	5
Bond Count	74
Aromatic Bond Count	0

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Chemical Component Summary
Name	(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL
Synonyms	VITAMIN D3
Systematic Name (OpenEye OEToolkits)	(1S)-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
Formula	C₂₇ H₄₄ O
Molecular Weight	384.638
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	OC3CC(=C/C=C1\CCCC2(C)C(C(C)CCCC(C)C)CCC12)\C(=C)CC3
SMILES	CACTVS	3.341	CC(C)CCC[CH](C)[CH]1CC[CH]2C(CCC[C]12C)=CC=C3C[CH](O)CCC3=C
SMILES	OpenEye OEToolkits	1.5.0	CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Canonical SMILES	CACTVS	3.341	CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C(/CCC[C@]12C)=C\C=C3/C[C@@H](O)CCC3=C
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CCCC2=CC=C3C[C@H](CCC3=C)O)C
InChI	InChI	1.03	InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/t21-,24+,25-,26+,27-/m1/s1
InChIKey	InChI	1.03	QYSXJUFSXHHAJI-RWDMXNMGSA-N

Drug Info: DrugBank

DrugBank ID	DB00169 ?
Name	Cholecalciferol
Groups	approved nutraceutical
Description	Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight [L5689]. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake [L5689]. Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 [L5689]. Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use [L5689]. Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism [A223, L5689, L1782, L5771, F4027, F4042, F4048]. However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency [L5689].
Synonyms	Colecalciferol (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol Cholecalciferol (+)-vitamin D3 Vitamin D3 Colecalciferolum Activated 7-dehydrocholesterol Cholecalciferolum Oleovitamin D3 Calciol CC Vitamin D-3 (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
Brand Names	P.R.O. Complex Milltrium Senior Vitamin and Mineral Supplement Hautuki A + D Ointment CitraNatal Medley Enrich Core Pack - Children Vitamin and Mineral Supplement Folika-D Men's Biomultiple Vitamin and Mineral Supplement PR Natal 400 ec Poly-Vitamin with Fluoride LiquiCal Plus Folitin-Z Mid-life Magnacal 2 PrePLUS Riva-D 50000 Iu Multivitamins and Minerals - Complete Re Ob 90 DHA PreTAB Port A Mins Super Cal-mag 300/150 With Vitamin D3 Hvp Chelated Cal/mag With Zinc and Vitamins C and D FolaMed DHA Vita-Rx Diabetic Vitamin Poly-Vi-Flor with Iron Natalvirt Ca PreNatal 19 Multi Vitamin - Mineral PNV-Select Triveen-PRx RNF Nexa Select Rx Prenatal Vitamin with Plant-Based DHA Osteoshield Antiseptic Skin Cream Sincera - Tablets Fortamines 10 Capsules PreFol-DHA Triple-Vitamin Drops with Fluoride Virt-Nate TriStart ONE Prena1 Plus AzesChew Multi-Vitamin Fluoride Vol-Plus Multi Vitamin & Minerals Kids Stuff Tablets LiquiCal with Magnesium Prenatvite Complete Sodium Fluoride and Vitamin D Drops Vitamin D + Calcium Dietary Supplement Preplus Cod Liver Oil Cap VIL-Rx Chela Calmag-100 Plus Zinc D3 Tendera-OB Vita Balance 2000 Prenate Pixie Calcium Citrate With Vitamin D Multi-actin G.A.S. Complex Novel-D3 Folcyteine Se-Plete DHA Natavite Calcium With Magnesium and Vitamin D Medi Tab Cifrazol Neonatal DHA Prometa O-calcium 250mg Plus D TriStart FREE Multivitamins and Minerals With Betacarotene Tablets Vitamin D 1000iu Multi-Vitamin With Fluoride DuetDHA Complete T.A. Vit A & D Ointment Multivitamines Et Mineraux Junior Regulier Efferlife Multivitamins and Minerals D- Trol VITAMIN D3 50000 IU Dietary Supplement Osteo Tablets Ostachol Vinate Care Focalgin CA For Kids Only Chewable Multivitamins Nutri-Tab OB Mebolex Nutra-Z WesNate DHA Vena-Bal DHA Trinatal GT For Kids Only Chewable Multivit. Plus Iron Osteo-force Escavite Lq Poly-Vite Pediatric Oral Solution Pregvit Folic 5 WellFola Ziphex Calcium Folic Acid Plus D Chewable Premium Prenatal - Tablets OB Complete 400 O-Cal Prenatal Vitamin Folet DHA Neomultivite Poly-Vite/Iron Oral Solution Apcal Zolate Multi-Vit with Fluoride and Iron Ciferex Prenate Star Viva Kids - Tab Central-vite 18 Essential Acti-cal/mag 2:1 + Zinc and D Caplet Premium Prenatal Vyqua Multiple Vitamins & Minerals Tablets High Potency Multivitamins & Minerals Caplets Se-Natal 19 Chewable NESTABS Prenatal Multi-vitamin/Mineral Supplement Liquid Calcium and Magnesium With Vit.d Senior Multi One VP CH Ultra Se-Natal 19 Multi-vitamins Cavan-EC SOD DHA Osteo-plus Multi Vitamin Drops with Fluoride with Iron Nutri-chem Calcium Magnesium With D and Zinc Taron-prex Prenatal One A Day Bone Builder RE Prenatal Multivitamin with Iron Taron BC Zyvana T-PA Cap Calcium and Magnesium With Vitamin D Genicin Vita-Q PNV Tabs 29-1 Multi Vitamin Drops with Fluoride and Iron Calcium 250 Mg With Vitamin D Lexazin Multi #2 NuFera Multivitamines Pour Enfants (chewable Tablets) Multi - N.T.O.x Formula - Tab FolaPrime Poly-Vi-Flor Revesta Citranatal B-calm Triveen-Duo DHA Pediatric Infuvite Multiple Vitamins Pnv-OB-dha D-Vite Pediatric Oral Liquid Bal-Care DHA Multi-Vit-Flor Childrens Chewable Vitamins Multivitamins for Children WesNatal DHA Complete Cavan Folate DHA YYUX Organic Liquid Vitamin D3 Drops For Kids 4 plus years 600 IU Animal Shapes w/Iron Chewtabs Vita-Pac Escavite Duet DHA Balanced Tricare Prenatal DHA One Rx Multivitamin PramLyte Children's Chewable Multiple Vitamins - Tab PM Caps Tri-Vite Pediatric Oral Solution Quflora FE Ventrixyl Dexatrim Tablets Essential Vitamins and Minerals Extra P.N. Vitamin-mineral Drink Mix Rulavite DHA Euro D 10 000 Finazol Vita-desic Zintrexyl-C Florafol Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Omniquin Fosavance Extra-Virt Plus DHA Prenatol-M Multi-Vitamin Fluoride and Iron Drops One Per Day Vitamin and Mineral Dietary Supplement Active OB Corvite FE Select OB Vitamin D3 Oral Solution Children Vitamin Drops Multitol-M Osteo-life Animal Shapes TL-Care DHA Pro His Mint Corvite Free Decara Vitamin D Multivitamin with 0.25 mg Fluoride Mor-vites Tab Foliflex Menatrol PR Natal 430 ec Zavara Men's Neo-vites & Minerals Tab Actical Plus Calcium-magnesium-vitamin D3-silicon Chewable Ply Vi Sol Chewable Tab Paramettes Multivits Plus Iron Tab (teens) Vp-pnv-dha Avon Vitadvance Multi-kids Complete Virt-Care One Silexin Multivit with Fluoride Provida OB Duet DHA 400 ec Liqui Cal-D Gestamine Comprimes Prenatal Vitamins and Minerals Tablets Twin G.F. Powder Tobakient Calcium With Vitamin D 200 Mg/160 Iu MultiVitamin with Fluoride Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mg Gesticare DHA Livita Adults 24 Multivitamins + Minerals Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu Folvite-D Melittin Joint Soothing Ge Multivitamines Et Mineraux Reguliers / Regular Multivitamins and Minerals MultiVitamin with Fluoride Drops Folcaps Care One Usana Optimizer Actical Plus Calcium-magnesium-vitamin D3-silicon Tablets V & M Vitamin and Mineral Supplement Chewable Children's Complete Multivitamins With Essential Minerals N.E.U. Complex CitraNatal Harmony 3.0 Vitamin D3 Dietary Supplement Multivitamin & Multimineral Provida DHA Vitafol Ultra Junior Multi Vitamins - Regular 50 Plus Multiple Vitamins & Minerals Pnv-dha Prenatal Formula Tab VirtPrex Vital-D Rx Tri-Vit With Fluoride And Iron Drops Multinate DHA Vitranol Fe RE FAC-x Folgard NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Virt-Nate DHA Renate DHA Tri-Vitamin with Fluoride VITAMINS A, C, D and FLUORIDE Usana Megavitamin Tablets - Tab Multiple Vitamins Folcal DHA Usana Calmag Plus Tablets - Tab Alendronate-cholecalciferol B & J Formula Dietary Supplement OBTREX DHA Combo Pack Vitamin D3 Wellness Formula RediChew Nutrifer Plus Tablets Men's 50+ Isotonix Multitech Vitamin Mineral Supplemen Vitafol Fe Plus Poly-VI-flor healthy mamaBE WELL ROUNDED BE WELL ROUNDED PR Natal 430 Cavan Heme OB Se-Natal One Men's Multi Master Formula YYUX Organic Liquid Vitamin D3 plus K2 Drops Liquid Calcium Mg Phosphorus and Vit.d-3 Onyx Strovite One Caplets Livita Children Adult Formula 50+ Infuvite Pediatric Maintain Multiple Vitamin & Minerals Cavan Prenatal Duet DHA 400 Prenatal Plus Multivitamin Plus DHA MiniCaps Cavan One Multicaps Natal PNV Renate Super Kids Chewable Multivitamin Multimineral (chewable Tablets) D Caps 400 Units CyFolex Folcaps Omega-3 CitraNatal B-Calm Nutrilite Double X Poly-Vi-Flor Gummies Palm Springs Multvit and Min Tab Liquid Calcium With Vitamin D High Potency Calcium CompleteNate Chewable Isotonix Calcium Plus Formula Triple Vitamin Drops with Fluoride Multi Vitamin with Fluoride Obstetrix DHA Combo Pack HemeNatal OB plus DHA Formula Osg Jamp-vitamin D Daily-Vite OB Complete Petite Multivitamins and Minerals for Men Vita-vim With Beta-carotene - Tab Prena1 Enviroflex - Tab INATAL Ultra Multra Plex Infants' Multiple Vitamin Drops RE Nata OB PreferaOB plus DHA Riva-D WesCap-PN DHA Amerix Multivitamin Grand Master Formula Tab Calcium With Mg Zn Mn Cu CR Si and Vit. C & D PreQue 10 Relnate DHA Euro-D 5000 Iu Vitamin D 400 Iu Tablets Prenatal Plus Vitamins L.I.P. Complex Magnacal Multivitamin & Minerals (iron Free) Teva-alendronate/cholecalciferol Children's Vitamins Chewable Vita Day Tab Swiss One Multivitamin and Mineral Caplet ProFola Maximum Once A Day Bear Essentials C. Vit-min Formula Tricare Prenatal 2-part Daily Prenatal Vitamin System Sweet Sixteen - Tab Cal-mag Citrate Zinc & Vitamin D Tablets Iprical Materna Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA TL-Select Multivitamins and Minerals for Women Twin Opti Pwr Foltabs Prenatal Plus DHA Spectrum Performa Multivitamins and Minerals Tablets Osteo Formula Tab Trinatal Ultra NovaDHA Baby DHA Super Vita-vim With Beta-carotene - Tab Folika-MG Edge OB Zalvit Multivitamin Drops with Fluoride Calci-yum Plus Magnesium + D3 Chewable Multivitamins Floriva Plus Nutri-Tab OB plus DHA Pregvit Floriva VP-HEME One Obtrex One Ultimate Tab Super Cal Mag Plus Prenatal Vitamins Plus Multivitamins and Minerals for Young Women Pregnancy Multivitamin Folic 5 Omnivex Extra Once A Day Prenate Mini Only One - Tablet Se-Care Chewable PR Natal 400 PNV Prenatal Vitamin Plus Vitamin A Children's Vitamins W Iron Chewable Vitamins A, C, D and Fluoride Drops Viva CT Prenatal Onevite RenaPlex-D Multi Vitamin and Fluoride Pregnancy Multivitamin Kids Stuff With Iron Tablets Natalvirt 90dha P.N.P. Vitamin Drink NovaFerrum 125 Vitamin D3 50mcg (2000IU) Ribotin-E Multi Mega Minerals With Vitamin D VITAMIN D3 1.25 MG 50000 IU Dietary Supplement Vinate AZ Super-pote Vitamin Supplement Am Caps Nexa Select Decara K Vegicaps Multivitamins and Minerals Tablets Quflora Pediatric Drops Prenatvite Plus Virt-Advance YYUX Organic Liquid Vitamin D3 Drops 1000 IU Citrate De Calcium Plus Vitamine D Et Zinc Fortamines-10 Comprimes L.C. Supplement algeaSAN reg Pro Hers Vanilla Multivitamin with 1.0 mg Fluoride Actonel Sachet Kit Multi-vitamins With Minerals Natural Source Spectrum With Beta Carotene Cavan Folate OB Dyzbac Vitamin & Mineral Formula 1 Dietary Supplement Vitrexate FE Prenatal Plus Iron Multivitamin Ventrixyl Fe Liquid Cal/mag Plus D Children's Chewable Multivitamin Complete With Minerals D-Cal SoyCal Rocky Mountain Multiple Vit and Min Mega Tab Tri-Vitamin with iron and fluoride Redoxon-cal Quflora FE Pediatric Drops Tri-VI-sol Drops RayaVit FolaMax YYUX Vegan Baby Liquid Vitamin D3 Drops 400 IU A.R.T.H. Away Formula Calcium/magnesium/vitamin D - Capsule Multi-Vitamin Drops with Fluoride and Iron Multinate DHA Extra Virt-Pn DHA Zyvit Neonatal Plus Vitamin Materna - Tab Animi-3 with Vitamin D Vitaphil DHA FloraFol Numark Multivitamins PNV-Omega Tricare Prenatal Quick Dissolve Virt-Bal DHA Plus PreferaOB ONE PRENATE Restore YYUX Organic Liquid Vitamin D3 Drops For Baby 0-3 years 400 IU Vp-gstn Active FE Foltabs Prenatal Fosamax Plus D Twin G.F. Powder Vanilla Flavor Multi-Vitamin Fluoride Drops Pure Calcium calcium Mega Vitaminerals Zatean-Pn Vitamin D3-softgel Capsules Vitramyn Children's Chewable Multiple Vit.plus Iron Cavan Alpha Garfield Chewable Multivits Plus Iron Tab Multi-vitamin Dietary Supplement Apo-alendronate/vitamin D3 Infuvite Adult Nephrocaps-QT Moms Choice Rx Marnatal F Fosteum Materna-tab Nrg Plus Liq Pretrate Prenaissance Davimet with Fluoride Vol-Nate TriStart DHA Xyzmune Zatean-Pn Plus Riva-D 10000 Iu Dry Super Vitamin A Plus D - Cap Pro Pcos Citrus Vitamin D Folet One Cholecal DF PNV Tabs 20-1 Calcium Complex High Grade Calcium 600 + D Prefera OB plus DHA Prenatal Supplement - Tab VP CH Plus Vitaday Junior Tab O-Cal FA multivitamin Calcium 600mg + Vit D3 125unit Tab Cal-mag Complete With Zinc, C and D Port A Mins Super Calcium 375 With Vitamin D3 PRENATE Enhance Thrivite Rx Vidextra Multi-Vit with Fluoride Complete Multivitamins and Minerals for Children Orifer F Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops Tricare Prenatal Virt-Tabs Obstetrix EC Prenate DHA Cataplex D Tab 400unit Multitam Oyster Shell Calcium with Vitamin D Tricare Prenatal DHA One Multi-kid SetonET-EC Escavite D Quflora Pediatric Vantavo Calcium and Magnesium 1:1 Plus Tablets Euro-D 50000 Iu Chela Calmag-300 Plus Zinc D3 Supplement De Vitamines Et Mineraux Adrovance NEONATAL Complete VitaPhil Aide Prenaissance Plus Vp-heme Ob DHA Tri-Vi-Flor Vitafol TL-Folate Multivitamins and Multiminerals Formula Regular Tablet Prenatal C.H.V. Formula Children's Multivitamins With Iron Children's Chewable Multivitamins and Minerals Menocal Tab CitraNatal Assure Caltrate 600 Plus D - Tablet Iron Polysaccharides Folic Acid DHA Vinacal Trinatal Rx 1 Cod Liver Oil Oleovitamin A & D Caps 20min Women's Support Tablets D Vi Sol Infants Drops 400unit/0.6ml Select-OB Plus DHA Prenatal Supplement Plus DHA Multivitamins Osteo Formula Decalcitrol vitaMedMD One Rx Vp-heme Ob Vitamin D 400 Iu Calcium 500mg With Vitamin D Prenatal Plus Vtb Vitamin and Mineral Supplement Garfield Chewable Multivitamins Tab Children Choice Multivitamin W Iron Chew Tab Zavitrol PreferaOB One CitraNatal Essence Neonatal Vitamin Supplements De Vitamines Et Mineraux Obstetrix ONE Cal/mag 1:1 With Zinc and Vitamin D - Tablet Cal-mag With Zinc & Vitamin D Venexa FE Zatean-Pn DHA Nata Komplete Adult Infuvite Multiple Vitamins Sandoz Alendronate/cholecalciferol Kid's Choice Children's Chewable Vitamins - Tab Vp-CH-pnv Corvita Children Choice Multivit Chewable Tab For-2 Osteo Factors Avon Nutrivance Soft Calcium Chews With Vitamin D Imubolic Calcium-magnesium With K & Zn and Vitamin D3 Niva-Plus PreGenna Infant Multivitamin Drops Prevital Tab Keylosa Leonas Calcium Plus Vitamin D3 Osteo-Vit3 Vitamine D 10 000 Calcium Supplement Tab Amerix Vitamin D 3 Hormodausse Plus Calc Et D Tab TL-Select DHA Folplex Prenate Elite Calcium Et Magnesium Plus Vitamin D Tozal Cream Sun-rype Vitaburst Liquical Calcium 650mg With Vitamin D Multivitamins and Minerals for Young Men vitaMedMD Rx Plus Quflora Gummies Jamp Alendronate / Vitamin D3 Prenate Essential Xyzbac Derma-force Opti-cal Chewable +d Caplet Inatal Advance Nexa Plus Vitamines A - D Calcium Q.T. #4 Vitamin and Mineral Dietary Supplement Virt Vite GT Calplus Davimet-M Super Multi Genicin Vita-D NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Novel Vita Ag-vitamine D Mebolic PNV Ferrous Fumarate Docusate Folic Acid Nutra Boost Folika-V Thrivite 19 Nestabs ONE One Daily VITES algeaSAN pro Calcium & Vitamin D Vol-Tab Rx Children's Chewable Vit and Min Tab UltimateCare ONE NF Dexivite D-tabs Spark Cap Calcium & Magnesium Citrate Plus D With Manganese, Potassium & Zinc Decara High Potency Vitamin D3 Vegicaps PNV Prenatal Plus Multivitamin Riva-D 5000 Iu MultiVitamin, Iron and Fluoride Drops Mvc TriAdvance Luxa-D Vitaphil 90 DHA CitraNatal Harmony C-Nate DHA Prenatvite Multi Vitamins & Minerals Prenatal Vitamins Plus Low Iron Focalgin 90 DHA H.W. Children's Chewable Multi Vit & Mineral Advanced AM PM V-Natal DuetDHA Balanced Innersource Tab Calcium Plus Prenatrix Virt-PN Plus Prenatryl Euro-D 10000 Iu Aces Tab RE Nata Multitabs Florravite Multi Tabs For Kids Only Chewable Multivitamins - Tab Formula O-care Vitamin and Mineral Supplement Women's Biomultiple Vitamin and Mineral Supplement Adeks Tablets Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Tricare Prenatal Compleat Folivane-PRx DHA Chewable Multivitamins Plus Iron Tricare Prenatal DHA One With Folate Swical Extra-fort Paramettes Chewable Multivits With Iron Tab Coral Calcium Plus Vitamin D 210mg/100iu NataFort PreGen DHA Venexa PrimaCare Tri-Vit with Fluoride Drops Vitrexate Calma-D Dialyvite Supreme D OB Complete Gold natelle COMPLETE Ultimate OB DHA Virt-PN Choice OB DHA Jenliva MultiVitamin with Fluoride Chewable Vitafol Nano Zatean-CH Formula 3200 Waf 100unit Multi-Nate 30 Vitamin D3 Oral Solution VEGICAPS Azesco Osteo Regime Vitamin D-dry 400 I.U. Hi Potency Multi Tab Kimchi Vitamin chewable multivitamin MultiVitamin Drops with Fluoride and Iron Prenatabs FA Xyzbac G Medi-10 Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin D Milk Calcium With Vitamins C, D, and Phosphorous Folvik-D Dayavite Virt-Select PRENATAL/POSTNATAL Active Calcium Plus Magnesium, Vitamin D and Silicon Animi-3 Multivitamin with Fluoride Trinaz Multi Vitamin Plus Iron Vitranol K.L. Vitamin-mineral Oyster Shell Calcium OB Complete DHA Multra With Iron OB Complete Prenatal Complete-RF Prenatal Ag-vitamine D Tablets L-Methyl PNV DHA WestGel DHA Vita-vim - Tab Oncovite Multi-phyto Capsules Children's Chewable Multi-vitamin Complete With Minerals Growth Supportpatch, Hautuki Bseltzer Prenatal Vi-min Recal D UltimateCare ONE Multi-Vitamin with Fluoride PreNexa One Daily Vitamin and Mineral Dietary Supplement Paramettes Chewable Multivitamins Plus Iron Virt Nate Vitrexyl plus Iron Complete Natal DHA WesTab Plus Tri Vi Flor Tab KeyFolic PNV-First YYUX Vegan Mama Liquid Vitamin D3 Drops 600 IU Puralor PreferaOB Calcium Citrate and Vitamin D 200mg/160iu Envirocomplex VemaVite-PRx 2 with Fish-Based DHA Childrens Chewable Vitamin Tab SetonET Pnv Ob DHA Body Rox Duet DHA Prena1 Chew O Calcium 500mg Plus D Tab Corvite Prenatal, DHA Davimet Forty Plus Vitamin Supplement Liquid Opti-minplex +d Super Charged Energy Virt-Pn PNV Prenatal Vitamin Port A Mins Super Calcium 750 With Vitamin D3 Roxifol-D Multi Vitamin, Iron and Fluoride Noxifol-D Multi Vitamin Drops with Fluoride Q.T. Vitamin and Mineral Drink Mix Ortho Folic Davimet with Iron AxiFol Durachol PreNexa premier Folene Prenate Chewable Beta Carotene Provitamin A With D Children's Chewable Multi-vitamin Sandoz D 10 000 Women's Formula Virt-PN DHA Children's Chewable Multivitamins With Minerals PreNatal Vitamins Plus FolaGent DHA HemeNatal OB NataChew Bal-Care DHA Essential Vitrexyl Osteo-Poretical Pregvit Folic 4 Cod Liver Oil USP Abavite Amladex Multivitamines Plus Fer Pour Enfants (chewable Tablets) Prenatal and Post Partum Supplement
Indication	Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia [F4027, F4042]. Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others [A176041, A176044, F4051].
Categories	Alimentary Tract and Metabolism Bone Density Conservation Agents Calcium-Regulating Hormones and Agents Cholecalciferol, antagonists & inhibitors Cholestanes Cholestenes Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diet, Food, and Nutrition Drugs Affecting Bone Structure and Mineralization Drugs for Treatment of Bone Diseases Food Fused-Ring Compounds Growth Substances Lipids Membrane Lipids Micronutrients Musculo-Skeletal System Physiological Phenomena Secosteroids Steroids Sterols Vitamin D and Analogues Vitamins Vitamins (Fat Soluble)
ATC-Code	M05BB09 M05BX53 M05BB07 M05BB08 A11CC55 M05BB05 A11CC05 M05BB03 M05BB04
CAS number	67-97-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Vitamin D3 receptor	MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRR...	unknown	agonist
Vitamin D 25-hydroxylase	MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIG...	unknown	substrate
Sterol 26-hydroxylase, mitochondrial	MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGV...	unknown	substrate
Cytochrome P450 2J2	MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRL...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Cholesterol side-chain cleavage enzyme, mitochondrial	MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNE...	unknown	substrate
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	inhibitor
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Vitamin D-binding protein	MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSR...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682