Small Molecule Statistics: Growth of Released Small Molecules per Year
This chart shows the annual and cumulative numbers of the first release of chemical components (ligands, small molecules and monomers) described in Chemical Component Dictionary and peptide-like molecules described in Biologically Interesting molecule Reference Dictionary. Please note that the number of CCD and BIRD molecules released before 1999 was relatively small so please refer to the table below to view their counts.
| Year | Total Number of Small Molecules Available | Number of Small Molecules Released Annually |
|---|---|---|
| 1973 | 18 | 18 |
| 1976 | 34 | 16 |
| 1977 | 45 | 11 |
| 1978 | 69 | 24 |
| 1979 | 72 | 3 |
| 1980 | 88 | 16 |
| 1981 | 96 | 8 |
| 1982 | 113 | 17 |
| 1983 | 125 | 12 |
| 1984 | 132 | 7 |
| 1985 | 137 | 5 |
| 1986 | 148 | 11 |
| 1987 | 153 | 5 |
| 1988 | 173 | 20 |
| 1989 | 204 | 31 |
| 1990 | 251 | 47 |
| 1991 | 309 | 58 |
| 1992 | 354 | 45 |
| 1993 | 486 | 132 |
| 1994 | 772 | 286 |
| 1995 | 949 | 177 |
| 1996 | 1,156 | 207 |
| 1997 | 1,477 | 321 |
| 1998 | 1,829 | 352 |
| 1999 | 2,308 | 479 |
| 2000 | 2,800 | 492 |
| 2001 | 3,275 | 475 |
| 2002 | 3,743 | 468 |
| 2003 | 4,381 | 638 |
| 2004 | 5,107 | 726 |
| 2005 | 5,847 | 740 |
| 2006 | 6,756 | 909 |
| 2007 | 7,630 | 874 |
| 2008 | 8,784 | 1,154 |
| 2009 | 9,969 | 1,185 |
| 2010 | 11,252 | 1,283 |
| 2011 | 12,624 | 1,372 |
| 2012 | 14,682 | 2,058 |
| 2013 | 16,664 | 1,982 |
| 2014 | 18,575 | 1,911 |
| 2015 | 20,411 | 1,836 |
| 2016 | 22,628 | 2,217 |
| 2017 | 24,942 | 2,314 |
| 2018 | 27,456 | 2,514 |
| 2019 | 29,870 | 2,414 |
| 2020 | 33,159 | 3,289 |
| 2021 | 35,719 | 2,560 |
| 2022 | 38,896 | 3,177 |
| 2023 | 42,016 | 3,120 |
| 2024 | 44,926 | 2,910 |
| 2025 | 45,154 | 228 |
