Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2
Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.To be published.
Experimental Data Snapshot
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Bromodomain-containing protein 2 | 126 | Homo sapiens | Mutation(s): 1 Gene Names: BRD2, KIAA9001, RING3 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P25440 (Homo sapiens) Explore P25440 Go to UniProtKB: P25440 | |||||
PHAROS: P25440 GTEx: ENSG00000204256 | |||||
Entity Groups | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P25440 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 1 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
EDO Query on EDO | D [auth A], E [auth B], F [auth C] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( ? ) | Angle ( ? ) |
---|---|
a = 115.381 | α = 90 |
b = 55.757 | β = 94.76 |
c = 68.451 | γ = 90 |
Software Name | Purpose |
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REFMAC | refinement |
XDS | data reduction |
Aimless | data scaling |
PHASER | phasing |