Download MendeleyStructural mechanisms of human cardiac sodium calcium exchanger NCX1
Xue, J., Jiang, Y.To be published.
9IV8 | pdb_00009iv8
Cryo-EM structure of human NCX1 in PIP2 diC8 bound state
- PDB DOI: https://doi.org/10.2210/pdb9IV8/pdb
- EM Map EMD-60921: EMDB EMDataResource
- Classification: TRANSPORT PROTEIN
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Membrane Protein: Yes PDBTMMemProtMD
- Deposited: 2024-07-23 Released: 2025-03-19
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), Welch Foundation, Howard Hughes Medical Institute (HHMI)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.50 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Sodium/calcium exchanger 1 | 982 | Homo sapiens | Mutation(s): 0 Gene Names: SLC8A1, CNC, NCX1 Membrane Entity: Yes |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P32418 (Homo sapiens) Explore P32418 Go to UniProtKB: P32418 | |||||
PHAROS: P32418 GTEx: ENSG00000183023 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P32418 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PIO (Subject of Investigation/LOI) Query on PIO | C [auth A] | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate C25 H49 O19 P3 XLNCEHRXXWQMPK-MJUMVPIBSA-N |  | ||
| CA (Subject of Investigation/LOI) Query on CA | B [auth A], D [auth A], E [auth A], F [auth A], G [auth A] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.50 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | R35GM140892 |
| Welch Foundation | United States | I-1578 |
| Howard Hughes Medical Institute (HHMI) | United States | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-03-19
Type: Initial release
