1N6E

tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n6ea1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6ea2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6ea3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
A	d1n6ea4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
C	d1n6ec4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
E	d1n6ee4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
G	d1n6eg4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
I	d1n6ei4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek1	All beta proteins	PDZ domain-like	PDZ domain-like	Tail specific protease PDZ domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek2	All beta proteins	6-bladed beta-propeller	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek3	All beta proteins	7-bladed beta-propeller	Tricorn protease domain 2	Tricorn protease domain 2	Tricorn protease domain 2	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
K	d1n6ek4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Tail specific protease, catalytic domain	Tricorn protease	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PDZ domain-like	8037766	3000388	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Tricorn protease domain 2	8037768	3000315	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	ClpP/crotonase	8037769	3000033	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Tricorn protease N-terminal domain	8037767	3000291	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tricorn_PDZ	e1n6eA2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
A	DPPIV_N_1	e1n6eA4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
A	DPPIV_N	e1n6eA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
A	Tricorn_C1	e1n6eA5	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
A	Peptidase_S41	e1n6eA1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
C	Tricorn_PDZ	e1n6eC4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
C	DPPIV_N_1	e1n6eC5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
C	DPPIV_N	e1n6eC2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
C	Tricorn_C1	e1n6eC1	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
C	Peptidase_S41	e1n6eC3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
E	Tricorn_PDZ	e1n6eE1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
E	DPPIV_N_1	e1n6eE5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
E	DPPIV_N	e1n6eE4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
E	Tricorn_C1	e1n6eE3	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
E	Peptidase_S41	e1n6eE2	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
G	Tricorn_PDZ	e1n6eG5	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
G	DPPIV_N_1	e1n6eG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
G	DPPIV_N	e1n6eG4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
G	Tricorn_C1	e1n6eG2	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
G	Peptidase_S41	e1n6eG3	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
I	Tricorn_PDZ	e1n6eI4	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
I	DPPIV_N_1	e1n6eI1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
I	DPPIV_N	e1n6eI5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
I	Tricorn_C1	e1n6eI3	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
I	Peptidase_S41	e1n6eI2	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)
K	Tricorn_PDZ	e1n6eK3	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: Tricorn_PDZ	ECOD (1.6)
K	DPPIV_N_1	e1n6eK4	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DPPIV_N_1	ECOD (1.6)
K	DPPIV_N	e1n6eK5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: DPPIV_N	ECOD (1.6)
K	Tricorn_C1	e1n6eK2	A: alpha bundles	X: Tail specific protease helical domain (From Topology)	H: Tail specific protease helical domain (From Topology)	T: Tail specific protease helical domain	F: Tricorn_C1	ECOD (1.6)
K	Peptidase_S41	e1n6eK1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S41	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
A	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
C	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
E	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
E	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
E	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
E	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
G	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
G	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
G	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
G	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
I	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
I	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
I	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
I	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
I	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
K	2.120.10.60	Mainly Beta	6 Propeller	Neuraminidase	Tricorn protease N-terminal domain	CATH (4.3.0)
K	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
K	3.30.750.44	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA		CATH (4.3.0)
K	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
K	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K	PF03572	Peptidase family S41 (Peptidase_S41)	Peptidase family S41	-	Family
A, C, E, G, I A, C, E, G, I, K	PF14684	Tricorn protease C1 domain (Tricorn_C1)	Tricorn protease C1 domain	This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain [1].	Domain
A, C, E, G, I A, C, E, G, I, K	PF14685	Tricorn protease PDZ domain (Tricorn_PDZ)	Tricorn protease PDZ domain	This domain is the PDZ domain of tricorn protease [1].	Domain
A, C, E, G, I A, C, E, G, I, K	PF07676	WD40-like Beta Propeller Repeat (PD40)	WD40-like Beta Propeller Repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D, F, H, J B, D, F, H, J, L	DQTQKAAAELTFF	-	-	-
A, C, E, G, I A, C, E, G, I, K	Tricorn protease	peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K	IPR005151	Tail specific protease	Domain
A, C, E, G, I A, C, E, G, I, K	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR011659	WD40-like beta propeller	Repeat
A, C, E, G, I A, C, E, G, I, K	IPR028204	Tricorn protease C1 domain	Domain
A, C, E, G, I A, C, E, G, I, K	IPR029414	Tricorn protease, PDZ domain	Domain
A, C, E, G, I A, C, E, G, I, K	IPR012393	Tricorn protease	Family
A, C, E, G, I A, C, E, G, I, K	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR036034	PDZ superfamily	Homologous Superfamily