Annotations: 1C9H

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1c9ha_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	Calcineurin (FKBP12.6)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	FKBP immunophilin/proline isomerase	8022484	4001062	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Rotamase-like	8034864	3000622	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FKBP_C	e1c9hA1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FKBP12.6	protein binding binding signaling receptor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity FK506 binding amide binding organic cyclic compound binding macrolide binding nucleoside phosphate binding cyclic nucleotide binding protein binding binding signaling receptor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity FK506 binding amide binding organic cyclic compound binding macrolide binding nucleoside phosphate binding cyclic nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding transmembrane transporter binding channel regulator activity molecular function regulator activity transporter regulator activity molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity ion channel regulator activity calcium channel regulator activity channel inhibitor activity	cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development positive regulation of cell projection organization response to wounding system development positive regulation of response to wounding developmental process regulation of biological process regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of response to stimulus regulation of neuron projection regeneration regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process cellular developmental process regulation of response to external stimulus positive regulation of biological process cell development response to axon injury regulation of response to wounding positive regulation of response to stimulus cellular component organization neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development response to stress regulation of response to stress cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization biological regulation axon development neuron development cellular process positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization protein refolding primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process protein metabolic process macromolecule metabolic process positive regulation of cytosolic calcium ion concentration regulation of biological quality regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis negative regulation of biological process negative regulation of transport calcium ion transport localization negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of calcium ion transport cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to redox state sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum system process smooth muscle contraction muscle contraction muscle system process signaling intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction regulation of cytosolic calcium ion concentration protein localization establishment of protein localization nitrogen compound transport carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell regulation of hormone levels establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion cellular response to oxygen-containing compound cellular response to carbohydrate stimulus response to glucose response to chemical glucose homeostasis insulin secretion involved in cellular response to glucose stimulus hormone secretion protein localization to extracellular region peptide secretion secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus cellular response to monosaccharide stimulus secretion cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus peptide transport response to hexose cellular response to chemical stimulus protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion cell population proliferation cell activation lymphocyte activation leukocyte proliferation leukocyte activation immune system process mononuclear cell proliferation T cell activation lymphocyte proliferation T cell proliferation negative regulation of protein transport negative regulation of secretion negative regulation of hormone secretion negative regulation of secretion by cell regulation of peptide hormone secretion negative regulation of peptide hormone secretion negative regulation of establishment of protein localization regulation of protein secretion regulation of secretion negative regulation of protein secretion regulation of hormone secretion regulation of protein localization regulation of peptide secretion negative regulation of signaling negative regulation of cell communication negative regulation of peptide secretion regulation of secretion by cell negative regulation of protein localization regulation of signaling negative regulation of response to stimulus regulation of peptide transport negative regulation of insulin secretion involved in cellular response to glucose stimulus regulation of establishment of protein localization regulation of protein transport negative regulation of insulin secretion regulation of cellular localization regulation of insulin secretion regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell communication protein maturation by protein folding regulation of heart contraction regulation of system process cardiac muscle contraction circulatory system process regulation of cardiac muscle contraction regulation of blood circulation regulation of striated muscle contraction regulation of muscle contraction heart process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion striated muscle contraction regulation of multicellular organismal process blood circulation regulation of cardiac muscle contraction by calcium ion signaling regulation of muscle system process heart contraction negative regulation of intracellular signal transduction regulation of signal transduction regulation of intracellular signal transduction regulation of calcium-mediated signaling negative regulation of calcium-mediated signaling negative regulation of signal transduction 'de novo' protein folding response to nutrient levels response to nutrient response to vitamin E response to vitamin response to organic cyclic compound negative regulation of heart rate negative regulation of blood circulation negative regulation of heart contraction negative regulation of multicellular organismal process regulation of heart rate response to hydrogen peroxide response to oxidative stress response to reactive oxygen species nervous system process action potential propagation action potential transmission of nerve impulse neuronal action potential propagation regulation of membrane potential	cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane cytosol protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A	IPR050689	FKBP-type Peptidyl-prolyl cis-trans Isomerase	Family
A	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P68106	tuberous sclerosis atopic eczema endogenous depression lung lymphangioleiomyomatosis Lymphangiomatosis renal cell carcinoma disappearing bone disease mucocutaneous lymph node syndrome dry eye syndrome lymphangioma rheumatoid arthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.