1EUN

STRUCTURE OF 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE ALDOLASE FROM ESCHERICHIA COLI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1euna_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	KDPG aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1eunb_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	KDPG aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1eunc_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class I aldolase	KDPG aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Aldolase	8033029	3000445	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Aldolase	8033029	3000445	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aldolase	8033029	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldolase	e1eunA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldolase	ECOD (1.6)
B	Aldolase	e1eunB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldolase	ECOD (1.6)
C	Aldolase	e1eunC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldolase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01081	KDPG and KHG aldolase (Aldolase)	KDPG and KHG aldolase	This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate aldolase (KDPG-aldolase)	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	KDPG ALDOLASE	oxo-acid-lyase activity (4S)-4-hydroxy-2-oxoglutarate aldolase activity lyase activity catalytic activity carbon-carbon lyase activity 2-dehydro-3-deoxy-phosphogluconate aldolase activity aldehyde-lyase activity (R,S)-4-hydroxy-2-oxoglutarate aldolase activity oxaloacetate decarboxylase activity carboxy-lyase activity identical protein binding protein binding binding	Entner-Doudoroff pathway through 6-phosphogluconate carbohydrate metabolic process pyruvate metabolic process catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process carboxylic acid metabolic process primary metabolic process glyceraldehyde-3-phosphate metabolic process organic acid metabolic process aldehyde metabolic process organophosphate metabolic process phosphate-containing compound metabolic process Entner-Doudoroff pathway through 6-phosphogluconate carbohydrate metabolic process pyruvate metabolic process catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process carboxylic acid metabolic process primary metabolic process glyceraldehyde-3-phosphate metabolic process organic acid metabolic process aldehyde metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process Entner-Doudoroff pathway monocarboxylic acid metabolic process phosphorus metabolic process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B, C	IPR031338	KDPG/KHG aldolase, active site 2	Active Site
A, B, C	IPR000887	KDPG/KHG aldolase	Family
A, B, C	IPR031337	KDPG/KHG aldolase, active site 1	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.