1GT7

L-rhamnulose-1-phosphate aldolase from Escherichia coli

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gt7a_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1gt7b_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1gt7c_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1gt7d_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1gt7e_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1gt7g_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H	d1gt7h_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I	d1gt7i_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J	d1gt7j_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K	d1gt7k_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L	d1gt7l_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
M	d1gt7m_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
N	d1gt7n_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
O	d1gt7o_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
P	d1gt7p_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
Q	d1gt7q_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
R	d1gt7r_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
S	d1gt7s_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
T	d1gt7t_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1gt7f_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldolase_II	e1gt7A1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
B	Aldolase_II	e1gt7B1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
C	Aldolase_II	e1gt7C1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
D	Aldolase_II	e1gt7D1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
E	Aldolase_II	e1gt7E1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
G	Aldolase_II	e1gt7G1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
H	Aldolase_II	e1gt7H1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
I	Aldolase_II	e1gt7I1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
J	Aldolase_II	e1gt7J1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
K	Aldolase_II	e1gt7K1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
L	Aldolase_II	e1gt7L1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
M	Aldolase_II	e1gt7M1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
N	Aldolase_II	e1gt7N1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
O	Aldolase_II	e1gt7O1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
P	Aldolase_II	e1gt7P1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
Q	Aldolase_II	e1gt7Q1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
R	Aldolase_II	e1gt7R1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
S	Aldolase_II	e1gt7S1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
T	Aldolase_II	e1gt7T1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
F	Aldolase_II	e1gt7F1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
B	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
C	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
D	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
E	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
G	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
H	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
I	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
J	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
K	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
L	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
M	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
N	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
O	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
P	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
Q	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
R	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
S	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
T	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
F	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	PF00596	Class II Aldolase and Adducin N-terminal domain (Aldolase_II)	Class II Aldolase and Adducin N-terminal domain	This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	RHAMNULOSE-1-PHOSPHATE ALDOLASE	lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity rhamnulose-1-phosphate aldolase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	monosaccharide metabolic process carbohydrate metabolic process catabolic process carbohydrate catabolic process primary metabolic process small molecule metabolic process metabolic process cellular process monosaccharide catabolic process small molecule catabolic process pentose metabolic process pentose catabolic process rhamnose catabolic process hexose catabolic process monosaccharide metabolic process carbohydrate metabolic process catabolic process carbohydrate catabolic process primary metabolic process small molecule metabolic process metabolic process cellular process monosaccharide catabolic process small molecule catabolic process pentose metabolic process pentose catabolic process rhamnose catabolic process hexose catabolic process hexose metabolic process rhamnose metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR013447	Rhamnulose-1-phosphate aldolase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR036409	Class II aldolase/adducin N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR001303	Class II aldolase/adducin N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR050197	Aldolase class II family, sugar metabolism enzymes	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A, B	rhamnulose-1-phosphate aldolase M-CSA #645	L-Rhamnulose-1-phosphate aldolase (RhuA) is a Class II aldolase, which infers the use of a divalent metal ion as an electron sink in the catalytic mechanism of the aldol cleavage and addition reactions. RhuA catalyses the cleavage of L-rhmnulose-1-phosphate to dihydroxyacetone phosphate and L-lactaldehyde. This enzyme also catalyses the reverse direction in making a carbon-carbon bond. This enzyme shows similarities with L-fuculose-1-phosphate aldolase (FucA) and L-Ribulose-5-phosphate 4-epimerase (RibE).	Defined by 5 residues: GLU:A-117HIS:A-141HIS:A-143HIS:A-212GLU:B-171 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 4.1.2.19 (PDB Primary Data) Search M-CSA Motif + EC 4.1.2.19

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1GT7

L-rhamnulose-1-phosphate aldolase from Escherichia coli

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage