Annotations: 1I3O

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1i3o.1	Alpha and beta proteins (a/b)	Caspase-like	Caspase-like	Caspase catalytic domain	Apopain (caspase-3, cpp32)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1i3o.2	Alpha and beta proteins (a/b)	Caspase-like	Caspase-like	Caspase catalytic domain	Apopain (caspase-3, cpp32)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1i3o.1	Alpha and beta proteins (a/b)	Caspase-like	Caspase-like	Caspase catalytic domain	Apopain (caspase-3, cpp32)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1i3o.2	Alpha and beta proteins (a/b)	Caspase-like	Caspase-like	Caspase catalytic domain	Apopain (caspase-3, cpp32)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1i3oe_	Small proteins	Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	BIR domains of XIAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1i3of_	Small proteins	Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	BIR domains of XIAP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	BIR	e1i3oE1	A: few secondary structure elements	X: Inhibitor of apoptosis (IAP) repeat (From Topology)	H: Inhibitor of apoptosis (IAP) repeat (From Topology)	T: Inhibitor of apoptosis (IAP) repeat	F: BIR	ECOD (1.6)
F	BIR	e1i3oF1	A: few secondary structure elements	X: Inhibitor of apoptosis (IAP) repeat (From Topology)	H: Inhibitor of apoptosis (IAP) repeat (From Topology)	T: Inhibitor of apoptosis (IAP) repeat	F: BIR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.1460	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (4.3.0)
D	3.30.70.1470	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Caspase-like	CATH (4.3.0)
E	1.10.1170.10	Mainly Alpha	Orthogonal Bundle	Inhibitor Of Apoptosis Protein (2mihbC-IAP-1)	Chain A	CATH (4.3.0)
F	1.10.1170.10	Mainly Alpha	Orthogonal Bundle	Inhibitor Of Apoptosis Protein (2mihbC-IAP-1)	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
B, D	PF00656	Caspase domain (Peptidase_C14)	Caspase domain	-	Domain
E, F	PF00653	Inhibitor of Apoptosis domain (BIR)	Inhibitor of Apoptosis domain	BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, incl ...	BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin (Swiss:O15392) [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	CASPASE 3	enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function regulator activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein-containing complex binding binding protein binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function regulator activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein-containing complex binding binding protein binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity enzyme binding protease binding aspartic-type peptidase activity aspartic-type endopeptidase activity enzyme activator activity molecular function activator activity phospholipase A2 activator activity phospholipase activator activity lipase activator activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development negative regulation of lymphocyte proliferation regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation negative regulation of cellular process regulation of multicellular organismal process regulation of immune system process negative regulation of B cell activation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of biological process negative regulation of cell population proliferation cell population proliferation B cell activation biological regulation cell activation B cell proliferation negative regulation of B cell proliferation negative regulation of cell activation negative regulation of immune system process regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation leukocyte apoptotic process apoptotic process cell death programmed cell death catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy regulation of macroautophagy metabolic process process utilizing autophagic mechanism regulation of metabolic process glial cell apoptotic process response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus negative regulation of cell cycle cell cycle regulation of cell cycle primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of cellular process regulation of neuron apoptotic process signaling cellular response to chemical stress intracellular signal transduction cellular response to environmental stimulus cell communication signal transduction intrinsic apoptotic signaling pathway response to osmotic stress cellular response to osmotic stress apoptotic signaling pathway cellular response to chemical stimulus intrinsic apoptotic signaling pathway in response to osmotic stress cellular response to abiotic stimulus B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis fibroblast apoptotic process cytokine production regulation of cytokine production negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of protein stability regulation of biological quality response to light stimulus response to UV response to wounding cellular developmental process cell differentiation cell fate commitment system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus response to decreased oxygen levels response to hypoxia response to oxygen levels hemopoiesis cell development erythrocyte differentiation myeloid cell differentiation myeloid cell homeostasis erythrocyte homeostasis neuron recognition cell projection organization neuron projection development neuron projection fasciculation cellular component organization neurogenesis neuron differentiation axonal fasciculation cell recognition cellular component organization or biogenesis plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development muscle structure development striated muscle cell differentiation muscle cell differentiation response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species response to acid chemical response to amino acid epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation head development forebrain development brain development pallium development central nervous system development telencephalon development hippocampus development limbic system development negative regulation of T cell proliferation negative regulation of cell adhesion T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion regulation of activated T cell proliferation leukocyte cell-cell adhesion activated T cell proliferation cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation negative regulation of activated T cell proliferation epithelial cell apoptotic process T cell homeostasis execution phase of apoptosis protein maturation proteolysis protein processing response to hexose response to monosaccharide response to carbohydrate response to glucose embryonic epithelial tube formation chordate embryonic development anterior neural tube closure tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure response to corticosteroid response to lipid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to organic cyclic compound cellular response to nitrogen compound cellular response to staurosporine cellular response to organic cyclic compound response to staurosporine response to nitrogen compound response to alkaloid cellular response to alkaloid regulation of amide metabolic process amyloid precursor protein catabolic process positive regulation of protein metabolic process regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process regulation of primary metabolic process positive regulation of metabolic process amyloid-beta metabolic process positive regulation of macromolecule metabolic process amide metabolic process amyloid precursor protein metabolic process amyloid-beta formation regulation of protein metabolic process positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process platelet morphogenesis cell morphogenesis platelet formation rhythmic process ovulation cycle process gonad development reproductive system development reproductive process female gonad development sex differentiation multicellular organismal reproductive process female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction ovulation cycle development of primary sexual characteristics reproductive structure development luteolysis regulation of defense response regulation of response to external stimulus defense response pyroptotic inflammatory response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress positive regulation of defense response positive regulation of pyroptotic inflammatory response inflammatory response behavior learning or memory cognition cellular response to growth factor stimulus cell surface receptor signaling pathway neurotrophin TRK receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus neurotrophin signaling pathway response to growth factor enzyme-linked receptor protein signaling pathway response to nicotine response to cobalt ion response to metal ion biological process involved in interspecies interaction between organisms response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin response to estradiol response to peptide response to cytokine response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body neuronal cell body cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane death-inducing signaling complex membrane protein complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body neuronal cell body cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane death-inducing signaling complex membrane protein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B, D	CASPASE 3	enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function regulator activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein-containing complex binding binding protein binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function regulator activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein-containing complex binding binding protein binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity cysteine-type endopeptidase activity endopeptidase activity enzyme binding protease binding aspartic-type peptidase activity aspartic-type endopeptidase activity enzyme activator activity molecular function activator activity phospholipase A2 activator activity phospholipase activator activity lipase activator activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development negative regulation of lymphocyte proliferation regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation negative regulation of cellular process regulation of multicellular organismal process regulation of immune system process negative regulation of B cell activation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of biological process negative regulation of cell population proliferation cell population proliferation B cell activation biological regulation cell activation B cell proliferation negative regulation of B cell proliferation negative regulation of cell activation negative regulation of immune system process regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation leukocyte apoptotic process apoptotic process cell death programmed cell death catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy regulation of macroautophagy metabolic process process utilizing autophagic mechanism regulation of metabolic process glial cell apoptotic process response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus negative regulation of cell cycle cell cycle regulation of cell cycle primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of cellular process regulation of neuron apoptotic process signaling cellular response to chemical stress intracellular signal transduction cellular response to environmental stimulus cell communication signal transduction intrinsic apoptotic signaling pathway response to osmotic stress cellular response to osmotic stress apoptotic signaling pathway cellular response to chemical stimulus intrinsic apoptotic signaling pathway in response to osmotic stress cellular response to abiotic stimulus B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis fibroblast apoptotic process cytokine production regulation of cytokine production negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of protein stability regulation of biological quality response to light stimulus response to UV response to wounding cellular developmental process cell differentiation cell fate commitment system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus response to decreased oxygen levels response to hypoxia response to oxygen levels hemopoiesis cell development erythrocyte differentiation myeloid cell differentiation myeloid cell homeostasis erythrocyte homeostasis neuron recognition cell projection organization neuron projection development neuron projection fasciculation cellular component organization neurogenesis neuron differentiation axonal fasciculation cell recognition cellular component organization or biogenesis plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development muscle structure development striated muscle cell differentiation muscle cell differentiation response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species response to acid chemical response to amino acid epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation head development forebrain development brain development pallium development central nervous system development telencephalon development hippocampus development limbic system development negative regulation of T cell proliferation negative regulation of cell adhesion T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion regulation of activated T cell proliferation leukocyte cell-cell adhesion activated T cell proliferation cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation negative regulation of activated T cell proliferation epithelial cell apoptotic process T cell homeostasis execution phase of apoptosis protein maturation proteolysis protein processing response to hexose response to monosaccharide response to carbohydrate response to glucose embryonic epithelial tube formation chordate embryonic development anterior neural tube closure tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium anatomical structure morphogenesis tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure response to corticosteroid response to lipid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to organic cyclic compound cellular response to nitrogen compound cellular response to staurosporine cellular response to organic cyclic compound response to staurosporine response to nitrogen compound response to alkaloid cellular response to alkaloid regulation of amide metabolic process amyloid precursor protein catabolic process positive regulation of protein metabolic process regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process regulation of primary metabolic process positive regulation of metabolic process amyloid-beta metabolic process positive regulation of macromolecule metabolic process amide metabolic process amyloid precursor protein metabolic process amyloid-beta formation regulation of protein metabolic process positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process platelet morphogenesis cell morphogenesis platelet formation rhythmic process ovulation cycle process gonad development reproductive system development reproductive process female gonad development sex differentiation multicellular organismal reproductive process female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction ovulation cycle development of primary sexual characteristics reproductive structure development luteolysis regulation of defense response regulation of response to external stimulus defense response pyroptotic inflammatory response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress positive regulation of defense response positive regulation of pyroptotic inflammatory response inflammatory response behavior learning or memory cognition cellular response to growth factor stimulus cell surface receptor signaling pathway neurotrophin TRK receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus neurotrophin signaling pathway response to growth factor enzyme-linked receptor protein signaling pathway response to nicotine response to cobalt ion response to metal ion biological process involved in interspecies interaction between organisms response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin response to estradiol response to peptide response to cytokine response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body neuronal cell body cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane death-inducing signaling complex membrane protein complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body neuronal cell body cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane death-inducing signaling complex membrane protein complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
E, F	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process cysteine-type endopeptidase regulator activity involved in apoptotic process protein binding binding protein serine/threonine kinase binding kinase binding enzyme binding protein kinase binding cation binding ion binding metal ion binding small molecule binding identical protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response response to external biotic stimulus nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway positive regulation of innate immune response defense response regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway defense response to symbiont immune system process nucleotide-binding oligomerization domain containing 1 signaling pathway regulation of protein modification process positive regulation of protein metabolic process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process protein ubiquitination positive regulation of macromolecule metabolic process protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal defense response to bacterium response to bacterium regulation of protein maturation negative regulation of proteolysis regulation of catalytic activity negative regulation of catalytic activity protein maturation negative regulation of peptidase activity regulation of proteolysis proteolysis zymogen inhibition negative regulation of protein metabolic process regulation of cysteine-type endopeptidase activity negative regulation of metabolic process regulation of peptidase activity regulation of gene expression regulation of molecular function negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process regulation of hydrolase activity regulation of protein processing protein processing negative regulation of cysteine-type endopeptidase activity regulation of macromolecule biosynthetic process negative regulation of hydrolase activity negative regulation of protein maturation negative regulation of endopeptidase activity inhibition of cysteine-type endopeptidase activity regulation of endopeptidase activity negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of molecular function gene expression macromolecule biosynthetic process negative regulation of biosynthetic process negative regulation of protein processing inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis copper ion homeostasis monoatomic cation homeostasis nucleotide-binding oligomerization domain containing 2 signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway cellular response to endogenous stimulus BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor positive regulation of JNK cascade JNK cascade positive regulation of MAPK cascade regulation of JNK cascade regulation of MAPK cascade MAPK cascade protein polyubiquitination protein K63-linked ubiquitination regulation of inflammatory response inflammatory response neuron apoptotic process cell population proliferation regulation of cell population proliferation Wnt signaling pathway positive regulation of protein linear polyubiquitination regulation of protein linear polyubiquitination regulation of protein polyubiquitination positive regulation of protein polyubiquitination protein linear polyubiquitination regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway regulation of apoptosis involved in tissue homeostasis multicellular organismal process homeostasis of number of cells within a tissue tissue homeostasis multicellular organismal-level homeostasis anatomical structure homeostasis homeostasis of number of cells cell cycle regulation of cell cycle positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of type I interferon production type I interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production regulation of type I interferon production negative regulation of signaling response to cytokine negative regulation of cell communication cytokine-mediated signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus regulation of tumor necrosis factor-mediated signaling pathway negative regulation of response to stimulus regulation of cytokine-mediated signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of signal transduction response to peptide regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway response to chemical response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
A, C	IPR001309	Peptidase C14, p20 domain	Domain
A, C	IPR011600	Peptidase C14, caspase domain	Domain
A, C	IPR016129	Peptidase family C14A, His active site	Active Site
A, C	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
A, C	IPR033139	Peptidase family C14A, cysteine active site	Active Site
A, C	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
B, D	IPR029030	Caspase-like domain superfamily	Homologous Superfamily
B, D	IPR001309	Peptidase C14, p20 domain	Domain
B, D	IPR011600	Peptidase C14, caspase domain	Domain
B, D	IPR016129	Peptidase family C14A, His active site	Active Site
B, D	IPR015917	Peptidase C14A, caspase catalytic domain	Domain
B, D	IPR033139	Peptidase family C14A, cysteine active site	Active Site
B, D	IPR002138	Peptidase C14, caspase non-catalytic subunit p10	Domain
E, F	IPR050784	Inhibitor of Apoptosis	Family
E, F	IPR048875	BIRC2/3-like, UBA domain	Domain
E, F	IPR011029	Death-like domain superfamily	Homologous Superfamily
E, F	IPR042579	XIAP/BIRC8, UBA domain	Domain
E, F	IPR001370	BIR repeat	Repeat
E, F	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P42574	Alzheimer disease status epilepticus diabetic retinopathy ulcerative colitis Diabetes Mellitus, Experimental diabetic polyneuropathy heart valve disease retinal detachment diabetic autonomic neuropathy diabetic neuropathy calcinosis type 2 diabetes mellitus cryptorchidism myocardial infarction diabetic peripheral angiopathy Alzheimer disease status epilepticus diabetic retinopathy ulcerative colitis Diabetes Mellitus, Experimental diabetic polyneuropathy heart valve disease retinal detachment diabetic autonomic neuropathy diabetic neuropathy calcinosis type 2 diabetes mellitus cryptorchidism myocardial infarction diabetic peripheral angiopathy nervous system disorder subarachnoid hemorrhage brain ischemia toxic encephalopathy colonic disease ischemia reperfusion injury schizophrenia coronary artery disease lung cancer maturity-onset diabetes of the young mucocutaneous lymph node syndrome stomach disease neurodegenerative disease ovarian cancer autoimmune disease eye disease pancreatic intraductal papillary-mucinous neoplasm breast disease glioblastoma prostate disease intracerebral hemorrhage kidney disease lung disease spinal cord injury ovarian disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia uterine disease hematologic disease inborn carbohydrate metabolic disorder invasive ductal breast carcinoma liver disease lymphatic system disease pancreatic intraductal papillary-mucinous carcinoma cancer heart disease cerebrovascular disorder vertebral column disease hepatitis
B, D	Pharos: P42574	Alzheimer disease status epilepticus diabetic retinopathy ulcerative colitis Diabetes Mellitus, Experimental diabetic polyneuropathy heart valve disease retinal detachment diabetic autonomic neuropathy diabetic neuropathy calcinosis type 2 diabetes mellitus cryptorchidism myocardial infarction diabetic peripheral angiopathy Alzheimer disease status epilepticus diabetic retinopathy ulcerative colitis Diabetes Mellitus, Experimental diabetic polyneuropathy heart valve disease retinal detachment diabetic autonomic neuropathy diabetic neuropathy calcinosis type 2 diabetes mellitus cryptorchidism myocardial infarction diabetic peripheral angiopathy nervous system disorder subarachnoid hemorrhage brain ischemia toxic encephalopathy colonic disease ischemia reperfusion injury schizophrenia coronary artery disease lung cancer maturity-onset diabetes of the young mucocutaneous lymph node syndrome stomach disease neurodegenerative disease ovarian cancer autoimmune disease eye disease pancreatic intraductal papillary-mucinous neoplasm breast disease glioblastoma prostate disease intracerebral hemorrhage kidney disease lung disease spinal cord injury ovarian disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia uterine disease hematologic disease inborn carbohydrate metabolic disorder invasive ductal breast carcinoma liver disease lymphatic system disease pancreatic intraductal papillary-mucinous carcinoma cancer heart disease cerebrovascular disorder vertebral column disease hepatitis
E, F	Pharos: P98170	X-linked lymphoproliferative disease due to XIAP deficiency esophageal cancer ovarian cancer Mammary Neoplasms, Experimental amyotrophic lateral sclerosis type 1 osteosarcoma pancreatic ductal adenocarcinoma X-linked lymphoproliferative disease due to SH2D1A deficiency amyotrophic lateral sclerosis intellectual disability lymphatic system disease myopathy pancreatic intraductal papillary-mucinous carcinoma breast cancer facioscapulohumeral muscular dystrophy X-linked lymphoproliferative disease due to XIAP deficiency esophageal cancer ovarian cancer Mammary Neoplasms, Experimental amyotrophic lateral sclerosis type 1 osteosarcoma pancreatic ductal adenocarcinoma X-linked lymphoproliferative disease due to SH2D1A deficiency amyotrophic lateral sclerosis intellectual disability lymphatic system disease myopathy pancreatic intraductal papillary-mucinous carcinoma breast cancer facioscapulohumeral muscular dystrophy juvenile dermatomyositis neoplasm of esophagus ovarian neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia X-linked lymphoproliferative syndrome cancer hematologic disease large cell medulloblastoma lymphoproliferative syndrome