1RYY

Acetobacter turbidans alpha-amino acid ester hydrolase Y206A mutant

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ryya1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
A	d1ryya2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
B	d1ryyb1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
B	d1ryyb2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
D	d1ryyd1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
D	d1ryyd2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
E	d1ryye1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
E	d1ryye2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
F	d1ryyf1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
F	d1ryyf2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
G	d1ryyg1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
G	d1ryyg2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
H	d1ryyh1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
H	d1ryyh2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
C	d1ryyc1	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	PepX C-terminal domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)
C	d1ryyc2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	Alpha-amino acid ester hydrolase	(Acetobacter pasteurianus ) [TaxId: 438 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	galactose-binding domain-like	8037044	3000087	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8037046	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PepX_C	e1ryyA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
A	Hydrolase_4	e1ryyA2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
B	PepX_C	e1ryyB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
B	Hydrolase_4	e1ryyB2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
D	PepX_C	e1ryyD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
D	Hydrolase_4	e1ryyD2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
E	PepX_C	e1ryyE1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
E	Hydrolase_4	e1ryyE2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
F	PepX_C	e1ryyF1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
F	Hydrolase_4	e1ryyF2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
G	PepX_C	e1ryyG1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
G	Hydrolase_4	e1ryyG2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
H	PepX_C	e1ryyH1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
H	Hydrolase_4	e1ryyH2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
C	PepX_C	e1ryyC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
C	Hydrolase_4	e1ryyC2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
A	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
B	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
D	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
E	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
E	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
E	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
F	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
F	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
F	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
G	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
G	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
G	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
H	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
H	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
H	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
C	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF08530	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain (PepX_C)	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	This domain contains a beta sandwich domain.	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF02129	X-Pro dipeptidyl-peptidase (S15 family) (Peptidase_S15)	X-Pro dipeptidyl-peptidase (S15 family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	alpha-amino acid ester hydrolase	peptidase activity catalytic activity, acting on a protein dipeptidyl-peptidase activity hydrolase activity exopeptidase activity catalytic activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity alpha-amino-acid esterase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005674	CocE/Serine esterase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR050585	Xaa-Pro dipeptidyl-peptidase/Cocaine esterase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000383	Xaa-Pro dipeptidyl-peptidase-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013736	Xaa-Pro dipeptidyl-peptidase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily