1TLU

Crystal Structure of Thermotoga maritima S-adenosylmethionine decarboxylase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1tlua_	Alpha and beta proteins (a+b)	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	Bacterial S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase (SamDC, SpeH)	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
B	d1tlub_	Alpha and beta proteins (a+b)	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	Bacterial S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase (SamDC, SpeH)	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	S-adenosylmethionine decarboxylase	8032696	3001051	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	S-adenosylmethionine decarboxylase	8032696	3001051	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AdoMet_dc	e1tluA1	A: a+b two layers	X: TBP-like	H: S-adenosylmethionine decarboxylase-related	T: Bacterial S-adenosylmethionine decarboxylase	F: AdoMet_dc	ECOD (1.6)
B	AdoMet_dc	e1tluB1	A: a+b two layers	X: TBP-like	H: S-adenosylmethionine decarboxylase-related	T: Bacterial S-adenosylmethionine decarboxylase	F: AdoMet_dc	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.90.10	Alpha Beta	4-Layer Sandwich	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	CATH (4.3.0)
B	3.60.90.10	Alpha Beta	4-Layer Sandwich	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02675	S-adenosylmethionine decarboxylase (AdoMet_dc)	S-adenosylmethionine decarboxylase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SamDC	adenosylmethionine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	polyamine metabolic process amine metabolic process biogenic amine biosynthetic process spermidine metabolic process biosynthetic process amine biosynthetic process polyamine biosynthetic process metabolic process cellular process spermidine biosynthetic process biogenic amine metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016067	S-adenosylmethionine decarboxylase, core	Homologous Superfamily
A, B	IPR042284	S-adenosylmethionine decarboxylase, N-terminal	Homologous Superfamily
A, B	IPR017716	S-adenosylmethionine decarboxylase proenzyme	Family
A, B	IPR003826	S-adenosylmethionine decarboxylase family, prokaryotic	Family
A, B	IPR042286	S-adenosylmethionine decarboxylase, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.