1U7Z

Phosphopantothenoylcysteine synthetase from E. coli, 4'-phosphopantothenoyl-CMP complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1u7zb_	Alpha and beta proteins (a/b)	Ribokinase-like	CoaB-like	CoaB-like	Coenzyme A biosynthesis bifunctional protein CoaBC, phosphopantothenoylcysteine synthase domain (CoaB)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1u7za_	Alpha and beta proteins (a/b)	Ribokinase-like	CoaB-like	CoaB-like	Coenzyme A biosynthesis bifunctional protein CoaBC, phosphopantothenoylcysteine synthase domain (CoaB)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1u7zc_	Alpha and beta proteins (a/b)	Ribokinase-like	CoaB-like	CoaB-like	Coenzyme A biosynthesis bifunctional protein CoaBC, phosphopantothenoylcysteine synthase domain (CoaB)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	CoaB-like	8042809	3001036	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	CoaB-like	8042809	3001036	SCOP2B (2022-06-29)
C	SCOP2 Family	CoaB-like	8030430	4001195	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	CoaB-like	8042809	3001036	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	DFP	e1u7zB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: DFP	ECOD (1.6)
A	DFP	e1u7zA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: DFP	ECOD (1.6)
C	DFP	e1u7zC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: DFP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.10300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CoaB-like	CATH (4.3.0)
A	3.40.50.10300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CoaB-like	CATH (4.3.0)
C	3.40.50.10300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CoaB-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF04127	DNA / pantothenate metabolism flavoprotein C-terminal (DFP)	DNA / pantothenate metabolism flavoprotein C-terminal	The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism. This entry represents the C-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Coenzyme A biosynthesis bifunctional protein coaBC	FMN binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acid-amino acid ligase activity phosphopantothenate--cysteine ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds FMN binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acid-amino acid ligase activity phosphopantothenate--cysteine ligase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity phosphopantothenoylcysteine decarboxylase activity carboxy-lyase activity lyase activity carbon-carbon lyase activity cation binding metal ion binding identical protein binding protein binding	catabolic process pantothenate metabolic process oxoacid metabolic process modified amino acid metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process modified amino acid catabolic process vitamin metabolic process vitamin catabolic process cellular catabolic process water-soluble vitamin catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process catabolic process pantothenate metabolic process oxoacid metabolic process modified amino acid metabolic process carboxylic acid metabolic process organic acid metabolic process organic acid catabolic process modified amino acid catabolic process vitamin metabolic process vitamin catabolic process cellular catabolic process water-soluble vitamin catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process metabolic process cellular process small molecule metabolic process amide metabolic process monocarboxylic acid metabolic process pantothenate catabolic process water-soluble vitamin metabolic process small molecule catabolic process nucleoside phosphate metabolic process coenzyme A biosynthetic process amide biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process nucleoside phosphate biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process phosphorus metabolic process coenzyme A metabolic process	protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm phosphopantothenoylcysteine decarboxylase complex cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036551	Flavin prenyltransferase-like	Homologous Superfamily
A, B, C	IPR005252	Coenzyme A biosynthesis bifunctional protein CoaBC	Family
A, B, C	IPR007085	DNA/pantothenate metabolism flavoprotein, C-terminal	Domain
A, B, C	IPR035929	CoaB-like superfamily	Homologous Superfamily
A, B, C	IPR003382	Flavoprotein	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.