2B2T

Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and phosphothreonine 3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2b2ta1	All beta proteins	SH3-like barrel	Chromo domain-like	Chromo domain	ATP-dependent helicase CHD1 (Chromo domain protein 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2b2ta3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2b2tb1	All beta proteins	SH3-like barrel	Chromo domain-like	Chromo domain	ATP-dependent helicase CHD1 (Chromo domain protein 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2b2tb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2b2tc1	All beta proteins	SH3-like barrel	Chromo domain-like	Chromo domain	ATP-dependent helicase CHD1 (Chromo domain protein 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Chromo domain-like	8037567	3000161	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Chromo domain-like	8037567	3000161	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Chromo domain-like	8037567	3000161	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Chromo	e2b2tA1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: Chromo	ECOD (1.6)
B	Chromo	e2b2tB1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: Chromo	ECOD (1.6)
C	Chromo	e2b2tC1	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: Chromo	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Provenance Source (Version)
A	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	CATH (4.3.0)
B	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	CATH (4.3.0)
C	2.40.50.40	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00385	Chromo (CHRromatin Organisation MOdifier) domain (Chromo)	Chromo (CHRromatin Organisation MOdifier) domain	-	Domain
C	PF00385	Chromo (CHRromatin Organisation MOdifier) domain (Chromo)	Chromo (CHRromatin Organisation MOdifier) domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Chromodomain-helicase-DNA-binding protein 1	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein binding binding histone binding chromatin binding ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein binding binding histone binding chromatin binding ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides methylated histone binding modification-dependent protein binding methylation-dependent protein binding	viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction cellular component organization protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling cellular process viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction cellular component organization protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling cellular process cellular component organization or biogenesis nucleosome organization	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome nuclear chromosome
C	Chromodomain-helicase-DNA-binding protein 1	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein binding binding histone binding chromatin binding ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein binding binding histone binding chromatin binding ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides methylated histone binding modification-dependent protein binding methylation-dependent protein binding	viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction cellular component organization protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling cellular process viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction cellular component organization protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling cellular process cellular component organization or biogenesis nucleosome organization	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome nuclear chromosome
D	Histone H3 tail	DNA binding binding organic cyclic compound binding nucleic acid binding cell adhesion molecule binding cadherin binding protein binding protein heterodimerization activity protein dimerization activity structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biosynthetic process protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process organelle organization telomere organization chromosome organization regulation of biosynthetic process regulation of biological process regulation of cellular process epigenetic regulation of gene expression biological regulation regulation of macromolecule metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process	cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle membraneless organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000330	SNF2, N-terminal	Domain
A, B	IPR023780	Chromo domain	Domain
A, B	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
A, B	IPR023779	Chromo domain, conserved site	Conserved Site
A, B	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
A, B	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR000953	Chromo/chromo shadow domain	Domain
A, B	IPR001650	Helicase, C-terminal domain-like	Domain
A, B	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A, B	IPR025260	Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain	Domain
A, B	IPR040793	CDH1/2, SANT-Helical linker 1	Domain
C	IPR000330	SNF2, N-terminal	Domain
C	IPR023780	Chromo domain	Domain
C	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
C	IPR023779	Chromo domain, conserved site	Conserved Site
C	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
C	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR000953	Chromo/chromo shadow domain	Domain
C	IPR001650	Helicase, C-terminal domain-like	Domain
C	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
C	IPR025260	Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain	Domain
C	IPR040793	CDH1/2, SANT-Helical linker 1	Domain
D	IPR009072	Histone-fold	Homologous Superfamily
D	IPR007125	Histone H2A/H2B/H3	Domain
D	IPR000164	Histone H3/CENP-A	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O14646	prostate cancer Pilarowski-Bjornsson syndrome colorectal cancer adrenal cortex carcinoma Crohn disease interstitial lung disease malignant glioma ovarian cancer colorectal adenoma diabetes mellitus large cell medulloblastoma malignant mesothelioma Prostatic Neoplasms glioblastoma lung cancer prostate cancer Pilarowski-Bjornsson syndrome colorectal cancer adrenal cortex carcinoma Crohn disease interstitial lung disease malignant glioma ovarian cancer colorectal adenoma diabetes mellitus large cell medulloblastoma malignant mesothelioma Prostatic Neoplasms glioblastoma lung cancer medulloblastoma primitive neuroectodermal tumor ulcerative colitis
C	Pharos: O14646	prostate cancer Pilarowski-Bjornsson syndrome colorectal cancer adrenal cortex carcinoma Crohn disease interstitial lung disease malignant glioma ovarian cancer colorectal adenoma diabetes mellitus large cell medulloblastoma malignant mesothelioma Prostatic Neoplasms glioblastoma lung cancer prostate cancer Pilarowski-Bjornsson syndrome colorectal cancer adrenal cortex carcinoma Crohn disease interstitial lung disease malignant glioma ovarian cancer colorectal adenoma diabetes mellitus large cell medulloblastoma malignant mesothelioma Prostatic Neoplasms glioblastoma lung cancer medulloblastoma primitive neuroectodermal tumor ulcerative colitis
D	Pharos: P68431	lung carcinoma glioblastoma glioma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma allergic rhinitis ovarian cancer autism spectrum disorder psoriasis cutaneous lupus erythematosus tuberculosis ependymoma gastric carcinoma Glioma of Brain, Familial lung carcinoma glioblastoma glioma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma allergic rhinitis ovarian cancer autism spectrum disorder psoriasis cutaneous lupus erythematosus tuberculosis ependymoma gastric carcinoma Glioma of Brain, Familial hypertensive disorder lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis astrocytoma (excluding glioblastoma) pancreatic intraductal papillary-mucinous carcinoma breast cancer spina bifida cystic fibrosis exocrine pancreatic carcinoma glioma susceptibility 1 invasive ductal breast carcinoma lung cancer malignant glioma medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm breast carcinoma subependymoma ductal breast carcinoma in situ gastric cancer hepatocellular carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	MSE	Parent Component: MET
C	MSE	Parent Component: MET
D	M3L	Parent Component: LYS RESID: AA0074 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083
D	TPO	Parent Component: THR RESID: AA0074 , AA0038 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083 , O-phospho-L-threonine MOD:00047