2A90 | pdb_00002a90

Crystal Structure of the tandem WWE domain of Drosophila Deltex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2a90a1	Alpha and beta proteins (a+b)	WWE domain	WWE domain	WWE domain	Deltex (Dx)	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	WWE domain	8021077	4003671	SCOP2 (2022-06-29)
A	SCOP2 Family	WWE domain	8021078	4003671	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WWE domain	8033457	3001237	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WWE domain	8033458	3001237	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	WWE	e2a90A1	A: beta barrels	X: WWE domain (From Topology)	H: WWE domain (From Topology)	T: WWE domain	F: WWE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.720.50	Alpha Beta	2-Layer Sandwich	Signal recognition particle alu RNA binding heterodimer, srp9/1		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02825	WWE domain (WWE)	WWE domain	The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Deltex protein	protein binding binding signaling receptor binding Notch binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SH3 domain binding protein binding binding signaling receptor binding Notch binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SH3 domain binding protein domain specific binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process imaginal disc development animal organ development anatomical structure development wing disc development localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport cellular response to stimulus regulation of cellular process developmental process imaginal disc development animal organ development anatomical structure development wing disc development localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication primary metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process regulation of Toll signaling pathway positive regulation of Toll signaling pathway Toll signaling pathway positive regulation of signaling Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway Notch receptor processing positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of Notch signaling pathway regulation of localization positive regulation of cellular component organization regulation of cellular component organization regulation of transport regulation of vesicle-mediated transport cellular component organization positive regulation of endocytosis positive regulation of transport cellular component organization or biogenesis regulation of endocytosis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle late endosome multivesicular body cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle late endosome multivesicular body vesicle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR039396	Deltex, C-terminal	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR004170	WWE domain	Domain
A	IPR039399	Deltex, C-terminal domain superfamily	Homologous Superfamily
A	IPR037197	WWE domain superfamily	Homologous Superfamily
A	IPR018123	WWE domain, subgroup	Domain
A	IPR001841	Zinc finger, RING-type	Domain
A	IPR039398	Deltex family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.