2BEI

X-ray structure of thialysine n-acetyltransferase (SSAT2) from homo sapiens

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2beia1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Diamine acetyltransferase 2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2beib_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Diamine acetyltransferase 2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8037929	3000403	SCOP2B (2022-06-29)
B	SCOP2 Family	N-acetyltransferase, NAT	8025550	4001800	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Acyl-CoA N-acyltransferases (Nat)	8037929	3000403	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acetyltransf_10_3	e2beiA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_3	ECOD (1.6)
B	Acetyltransf_10_3	e2beiB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Diamine acetyltransferase 2	acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity diamine N-acetyltransferase activity identical protein binding protein binding binding	amine metabolic process spermidine metabolic process spermidine acetylation polyamine acetylation metabolic process cellular process polyamine metabolic process biogenic amine metabolic process nor-spermidine metabolic process putrescine acetylation putrescine metabolic process spermine acetylation spermine metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B	IPR000182	GNAT domain	Domain
A, B	IPR051016	Diverse Substrate Acetyltransferase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96F10	acute myeloid leukemia breast cancer glioblastoma metabolic syndrome X pancreatic ductal adenocarcinoma skin basal cell carcinoma atrial fibrillation cutaneous melanoma IgA glomerulonephritis neuroblastoma pancreatic intraductal papillary-mucinous carcinoma triple-negative breast carcinoma brain glioma esophageal squamous cell carcinoma melanoma acute myeloid leukemia breast cancer glioblastoma metabolic syndrome X pancreatic ductal adenocarcinoma skin basal cell carcinoma atrial fibrillation cutaneous melanoma IgA glomerulonephritis neuroblastoma pancreatic intraductal papillary-mucinous carcinoma triple-negative breast carcinoma brain glioma esophageal squamous cell carcinoma melanoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm uterine corpus leiomyoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.