Annotations: 2BN3

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Insulin-like	8072339	3000307	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Insulin-like	8072339	3000307	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	INSULIN	protein binding binding signaling receptor binding insulin receptor binding hormone activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity identical protein binding	response to nutrient levels regulation of response to nutrient levels regulation of biological process negative regulation of response to food response to stimulus negative regulation of response to nutrient levels negative regulation of response to stimulus biological regulation negative regulation of biological process negative regulation of appetite regulation of response to food regulation of response to stimulus response to food response to chemical response to nutrient levels regulation of response to nutrient levels regulation of biological process negative regulation of response to food response to stimulus negative regulation of response to nutrient levels negative regulation of response to stimulus biological regulation negative regulation of biological process negative regulation of appetite regulation of response to food regulation of response to stimulus response to food response to chemical regulation of biological quality regulation of appetite regulation of localization regulation of body fluid levels multicellular organismal process negative regulation of lactation regulation of developmental process transport mammary gland development gland development negative regulation of transport localization multicellular organism development negative regulation of secretion anatomical structure development lactation regulation of multicellular organismal process developmental process regulation of multicellular organismal development regulation of transport secretion negative regulation of developmental process animal organ development establishment of localization regulation of secretion body fluid secretion regulation of lactation negative regulation of multicellular organismal process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process response to butyrate response to lipid response to fatty acid response to oxygen-containing compound cellular response to stimulus positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction Rho protein signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of intracellular signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction regulation of cell communication positive regulation of small GTPase mediated signal transduction positive regulation of signaling cellular response to nitrogen compound D-glucose import hexose transmembrane transport response to peptide hormone carbohydrate transport cellular response to endogenous stimulus response to hormone glucose import in response to insulin stimulus cellular response to hormone stimulus response to endogenous stimulus cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound transmembrane transport cellular response to chemical stimulus D-glucose transmembrane transport response to insulin monosaccharide transmembrane transport carbohydrate transmembrane transport cellular response to insulin stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction response to hexose response to monosaccharide response to carbohydrate response to glucose behavior feeding behavior monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process primary metabolic process glucose metabolic process protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization cellular developmental process positive regulation of cell development cell development positive regulation of cell maturation regulation of cell differentiation developmental maturation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation anatomical structure maturation cell differentiation cell maturation regulation of cell maturation positive regulation of cell population proliferation positive regulation of mammary gland epithelial cell proliferation epithelial cell proliferation epithelium development cell population proliferation positive regulation of epithelial cell proliferation tissue development regulation of mammary gland epithelial cell proliferation mammary gland epithelium development regulation of cell population proliferation positive regulation of multicellular organismal process regulation of epithelial cell proliferation mammary gland epithelial cell proliferation response to growth hormone system process steroid hormone secretion organic hydroxy compound transport estradiol secretion hormone secretion signal release regulation of hormone levels lipid localization cell-cell signaling lipid transport endocrine hormone secretion endocrine process lipid export from cell hormone transport negative regulation of catabolic process lipid catabolic process catabolic process regulation of lipid metabolic process negative regulation of metabolic process regulation of catabolic process regulation of lipid catabolic process regulation of primary metabolic process negative regulation of lipid metabolic process negative regulation of lipid catabolic process lipid metabolic process positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion regulation of hormone secretion regulation of peptide secretion peptide secretion positive regulation of hormone secretion amide transport positive regulation of peptide secretion regulation of peptide transport peptide transport regulation of insulin secretion peptide hormone secretion insulin secretion response to stress response to heat response to abiotic stimulus response to temperature stimulus response to acid chemical response to L-arginine response to amino acid chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis regulation of system process positive regulation of blood circulation circulatory system process regulation of blood circulation blood circulation positive regulation of lactation	cellular anatomical structure extracellular region extracellular space
A	INSULIN	protein binding binding signaling receptor binding insulin receptor binding hormone activity molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity identical protein binding	response to nutrient levels regulation of response to nutrient levels regulation of biological process negative regulation of response to food response to stimulus negative regulation of response to nutrient levels negative regulation of response to stimulus biological regulation negative regulation of biological process negative regulation of appetite regulation of response to food regulation of response to stimulus response to food response to chemical response to nutrient levels regulation of response to nutrient levels regulation of biological process negative regulation of response to food response to stimulus negative regulation of response to nutrient levels negative regulation of response to stimulus biological regulation negative regulation of biological process negative regulation of appetite regulation of response to food regulation of response to stimulus response to food response to chemical regulation of biological quality regulation of appetite regulation of localization regulation of body fluid levels multicellular organismal process negative regulation of lactation regulation of developmental process transport mammary gland development gland development negative regulation of transport localization multicellular organism development negative regulation of secretion anatomical structure development lactation regulation of multicellular organismal process developmental process regulation of multicellular organismal development regulation of transport secretion negative regulation of developmental process animal organ development establishment of localization regulation of secretion body fluid secretion regulation of lactation negative regulation of multicellular organismal process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death regulation of biosynthetic process positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process response to butyrate response to lipid response to fatty acid response to oxygen-containing compound cellular response to stimulus positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction Rho protein signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of intracellular signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction regulation of cell communication positive regulation of small GTPase mediated signal transduction positive regulation of signaling cellular response to nitrogen compound D-glucose import hexose transmembrane transport response to peptide hormone carbohydrate transport cellular response to endogenous stimulus response to hormone glucose import in response to insulin stimulus cellular response to hormone stimulus response to endogenous stimulus cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound transmembrane transport cellular response to chemical stimulus D-glucose transmembrane transport response to insulin monosaccharide transmembrane transport carbohydrate transmembrane transport cellular response to insulin stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction response to hexose response to monosaccharide response to carbohydrate response to glucose behavior feeding behavior monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process primary metabolic process glucose metabolic process protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization cellular developmental process positive regulation of cell development cell development positive regulation of cell maturation regulation of cell differentiation developmental maturation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation anatomical structure maturation cell differentiation cell maturation regulation of cell maturation positive regulation of cell population proliferation positive regulation of mammary gland epithelial cell proliferation epithelial cell proliferation epithelium development cell population proliferation positive regulation of epithelial cell proliferation tissue development regulation of mammary gland epithelial cell proliferation mammary gland epithelium development regulation of cell population proliferation positive regulation of multicellular organismal process regulation of epithelial cell proliferation mammary gland epithelial cell proliferation response to growth hormone system process steroid hormone secretion organic hydroxy compound transport estradiol secretion hormone secretion signal release regulation of hormone levels lipid localization cell-cell signaling lipid transport endocrine hormone secretion endocrine process lipid export from cell hormone transport negative regulation of catabolic process lipid catabolic process catabolic process regulation of lipid metabolic process negative regulation of metabolic process regulation of catabolic process regulation of lipid catabolic process regulation of primary metabolic process negative regulation of lipid metabolic process negative regulation of lipid catabolic process lipid metabolic process positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion regulation of hormone secretion regulation of peptide secretion peptide secretion positive regulation of hormone secretion amide transport positive regulation of peptide secretion regulation of peptide transport peptide transport regulation of insulin secretion peptide hormone secretion insulin secretion response to stress response to heat response to abiotic stimulus response to temperature stimulus response to acid chemical response to L-arginine response to amino acid chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis regulation of system process positive regulation of blood circulation circulatory system process regulation of blood circulation blood circulation positive regulation of lactation	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR022352	Insulin family	Family
B	IPR004825	Insulin	Family
B	IPR016179	Insulin-like	Domain
B	IPR022353	Insulin, conserved site	Conserved Site
B	IPR036438	Insulin-like superfamily	Homologous Superfamily
A	IPR022352	Insulin family	Family
A	IPR004825	Insulin	Family
A	IPR016179	Insulin-like	Domain
A	IPR022353	Insulin, conserved site	Conserved Site
A	IPR036438	Insulin-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.