Annotations: 2VZ8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2vz8ab	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Enoylreductase nucleotide-binding domain from fatty acid synthase (FAS)	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8aa	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	Enoylreductase substrate-binding domain from fatty acid synthase (FAS)	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8ac	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Ketoreductase domain from fatty acid synthase (FAS)	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a4	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase MAT	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a3	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Ferredoxin-like domain from acyl transferase MAT	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a9	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	pseudo-methyltransferase domain from fatty acid synthase (FAS)	pseudo-methyltransferase domain from fatty acid synthase (FAS)	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketoacyl synthase domain from fatty acid synthase (FAS)	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a7	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	Polyketide synthase dehydratase (PS-DH)-like	Dehydratase domain from fatty acid synthase (FAS)	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a5	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	Acyltransferase domain N-terminal linker	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2vz8a6	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of acyltransferase MAT	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	KASAT domain-like	8045091	4004293	SCOP2 (2022-06-29)
A	SCOP2 Family	PKS dehydratase-like	8050556	4006953	SCOP2 (2022-06-29)
A	SCOP2 Family	Thiolase-related	8055914	4000245	SCOP2 (2022-06-29)
A	SCOP2 Family	FabD-like	8055916	4003614	SCOP2 (2022-06-29)
A	SCOP2 Family	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055918	4001289	SCOP2 (2022-06-29)
A	SCOP2 Family	PKS methyltransferase-like	8055922	4007658	SCOP2 (2022-06-29)
A	SCOP2 Family	Alcohol dehydrogenase-like	8055924	4000010	SCOP2 (2022-06-29)
A	SCOP2 Family	Ketoreductase module of polyketide syntase	8055927	4000119	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	KASAT domain-like	8055913	3002319	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055921	3000149	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thiolase-like	8055915	3000122	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FabD/lysophospholipase-like	8055917	3001121	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055919	3001224	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8055923	3000118	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Zinc-containing alcohol dehydrogenase-like	8055926	3000040	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SDR-like	8055928	3000038	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055920	3000149	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GroES-like	8055925	3000002	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	KASAT domain-like	8055913	3002319	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055919	3001224	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FabD/lysophospholipase-like	8055917	3001121	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroES-like	8055925	3000002	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thiolase-like	8055915	3000122	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FabD/lysophospholipase-like	8055917	3001121	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SDR-like	8055928	3000038	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055920	3000149	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8055923	3000118	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	KASAT domain-like	8055913	3002319	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thioesterase/thiol ester dehydrase-isomerase-like	8055921	3000149	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8055926	3000040	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG1202_2nd	e2vz8A7	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: KOG1202_2nd	ECOD (1.6)
A	PS-DH_N	e2vz8A13	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_N	ECOD (1.6)
A	PS-DH_C_2	e2vz8A12	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_C_2	ECOD (1.6)
A	Acyl_transf_1_2nd	e2vz8A14	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd	ECOD (1.6)
A	KAsynt_C_assoc	e2vz8A11	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: KAsynt_C_assoc	ECOD (1.6)
A	ADH_zinc_N	e2vz8A8	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
A	KOG1202_1st	e2vz8A10	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: KOG1202_1st	ECOD (1.6)
A	adh_short_C2_1	e2vz8A9	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2_1	ECOD (1.6)
A	Methyltransf_11_3	e2vz8A6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_11_3	ECOD (1.6)
A	Acyl_transf_1_1st	e2vz8A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
A	ketoacyl-synt	e2vz8A2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
A	Ketoacyl-synt_C	e2vz8A3	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
B	KOG1202_2nd	e2vz8B9	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: KOG1202_2nd	ECOD (1.6)
B	PS-DH_N	e2vz8B8	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_N	ECOD (1.6)
B	PS-DH_C_2	e2vz8B7	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_C_2	ECOD (1.6)
B	KAsynt_C_assoc	e2vz8B11	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: KAsynt_C_assoc	ECOD (1.6)
B	ADH_zinc_N	e2vz8B4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
B	KOG1202_1st	e2vz8B10	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: KOG1202_1st	ECOD (1.6)
B	adh_short_C2_1	e2vz8B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: adh_short_C2_1	ECOD (1.6)
B	Methyltransf_11_3	e2vz8B5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_11_3	ECOD (1.6)
B	Acyl_transf_1_1st	e2vz8B3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
B	ketoacyl-synt	e2vz8B1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
B	Ketoacyl-synt_C	e2vz8B6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
A	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
A	3.10.129.110	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
B	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
B	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
B	3.10.129.110	Alpha Beta	Roll	Thiol Ester Dehydrase	Chain A	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13602	Zinc-binding dehydrogenase (ADH_zinc_N_2)	Zinc-binding dehydrogenase		Domain
A, B	PF02801	Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)	Beta-ketoacyl synthase, C-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	Domain
A, B	PF21089	Polyketide synthase dehydratase domain (PKS_DH_N)	Polyketide synthase dehydratase domain	This domain is part of a dehydratase domain found in diverse PKS enzymes. This domain adopts a HotDog fold.	Domain
A, B	PF00109	Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)	Beta-ketoacyl synthase, N-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].	Domain
A, B	PF16197	Ketoacyl-synthetase C-terminal extension (KAsynt_C_assoc)	Ketoacyl-synthetase C-terminal extension	-	Family
A, B	PF08242	Methyltransferase domain (Methyltransf_12)	Methyltransferase domain	Members of this family are SAM dependent methyltransferases.	Domain
A, B	PF08659	KR domain (KR)	KR domain	-	Family
A, B	PF21149	Fatty acid synthase, pseudo-KR domain (FAS_pseudo-KR)	Fatty acid synthase, pseudo-KR domain	Fatty acid synthase is a multifunctional enzyme that catalyses the de novo biosynthesis of long-chain saturated fatty acids, starting from acetyl-CoA and malonyl-CoA in the presence of NADPH [1-3]. This entry represents the pseudo-ketoreductase (pseu ...	Fatty acid synthase is a multifunctional enzyme that catalyses the de novo biosynthesis of long-chain saturated fatty acids, starting from acetyl-CoA and malonyl-CoA in the presence of NADPH [1-3]. This entry represents the pseudo-ketoreductase (pseudo-KR) domain which is catalytically inactive and supports the integrity of the active KR domain [1,3].	Domain
A, B	PF00698	Acyl transferase domain (Acyl_transf_1)	Acyl transferase domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	FATTY ACID SYNTHASE	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity acetyltransferase activity acyltransferase activity [acyl-carrier-protein] S-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acetyltransferase activity S-acyltransferase activity binding nucleoside phosphate binding 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity acetyltransferase activity acyltransferase activity [acyl-carrier-protein] S-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity S-acetyltransferase activity S-acyltransferase activity binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding vitamin binding amide binding modified amino acid binding phosphopantetheine binding fatty acyl-[ACP] hydrolase activity hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity malonyltransferase activity [acyl-carrier-protein] S-malonyltransferase activity S-malonyltransferase activity enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-CH group of donors enoyl-[acyl-carrier-protein] reductase (NADPH) activity fatty acid synthase activity (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity hydro-lyase activity lyase activity carbon-oxygen lyase activity	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B	IPR006162	Phosphopantetheine attachment site	PTM
A, B	IPR013217	Methyltransferase type 12	Domain
A, B	IPR020807	Polyketide synthase, dehydratase domain	Domain
A, B	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
A, B	IPR049391	Fatty acid synthase, pseudo-KR domain	Domain
A, B	IPR020843	Polyketide synthase, enoylreductase domain	Domain
A, B	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A, B	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
A, B	IPR050091	Polyketide and Nonribosomal Peptide Biosynthesis Enzymes	Family
A, B	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B	IPR036736	ACP-like superfamily	Homologous Superfamily
A, B	IPR014043	Acyl transferase domain	Domain
A, B	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B	IPR020806	Polyketide synthase-like, phosphopantetheine-binding domain	Domain
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B	IPR016039	Thiolase-like	Homologous Superfamily
A, B	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B	IPR014030	Beta-ketoacyl synthase-like, N-terminal	Domain
A, B	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily
A, B	IPR049900	Polyketide/metazoan fatty acid synthase, dehydratase domain	Domain
A, B	IPR001031	Thioesterase	Domain