2WSW

Crystal Structure of Carnitine Transporter from Proteus mirabilis

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Betaine transporter BetP-like	8049744	4006618	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SNF-like	8092924	3001654	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	BCCT	e2wswA1	A: alpha complex topology	X: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	H: Sodium:neurotransmitter symporter family (SNF)-like (From Topology)	T: Sodium:neurotransmitter symporter family (SNF)-like	F: BCCT	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02028	BCCT, betaine/carnitine/choline family transporter (BCCT)	BCCT, betaine/carnitine/choline family transporter	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	BCCT FAMILY BETAINE/CARNITINE/CHOLINE TRANSPORTER	organic cation transmembrane transporter activity carnitine transmembrane transporter activity 4-(trimethylammonio)butanoate transmembrane transporter activity modified amino acid transmembrane transporter activity secondary active transmembrane transporter activity (R)-carnitine transmembrane transporter activity antiporter activity active transmembrane transporter activity (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity transporter activity transmembrane transporter activity quaternary ammonium group transmembrane transporter activity	carnitine metabolic process modified amino acid metabolic process metabolic process cellular process amino-acid betaine metabolic process quaternary ammonium group transport 4-(trimethylammonio)butanoate transport localization nitrogen compound transport transport modified amino acid transport establishment of localization organic cation transport amino-acid betaine transport	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000060	BCCT transporter family	Family
A	IPR023449	L-carnitine/gamma-butyrobetaine antiporter CaiT	Family
A	IPR018093	BCCT transporter, conserved site	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	APC (Amino acid-Polyamine-organoCation) superfamily	Betaine/carnitine/choline transporters

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.