2Y7D

Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (Kce) from Candidatus Cloacamonas acidaminovorans (orthorombic form)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Dihydropteroate synthetase-like	8053324	3000643	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Dihydropteroate synthetase-like	8053324	3000643	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Dihydropteroate synthetase-like	8053324	3000643	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Dihydropteroate synthetase-like	8053324	3000643	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	BKACE	e2y7dC2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: BKACE	ECOD (1.6)
A	BKACE	e2y7dA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: BKACE	ECOD (1.6)
B	BKACE	e2y7dB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: BKACE	ECOD (1.6)
D	BKACE	e2y7dD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: BKACE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF05853	beta-keto acid cleavage enzyme (BKACE)	beta-keto acid cleavage enzyme	BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyses the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA [1]. The family is found to have at least 1 ...	BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyses the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA [1]. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	3-KETO-5-AMINOHEXANOATE CLEAVAGE ENZYME	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity 3-keto-5-aminohexanoate cleavage activity cation binding ion binding binding metal ion binding small molecule binding	lysine metabolic process catabolic process oxoacid metabolic process energy derivation by oxidation of organic compounds L-lysine catabolic process aspartate family amino acid metabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process fermentation cellular catabolic process nitrogenous compound fermentation carboxylic acid catabolic process L-lysine metabolic process lysine metabolic process catabolic process oxoacid metabolic process energy derivation by oxidation of organic compounds L-lysine catabolic process aspartate family amino acid metabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process fermentation cellular catabolic process nitrogenous compound fermentation carboxylic acid catabolic process L-lysine metabolic process small molecule metabolic process amino acid catabolic process aspartate family amino acid catabolic process lysine catabolic process carboxylic acid metabolic process L-amino acid catabolic process acetate metabolic process primary metabolic process generation of precursor metabolites and energy L-amino acid metabolic process anaerobic amino acid catabolic process proteinogenic amino acid metabolic process L-lysine catabolic process to acetate alpha-amino acid catabolic process proteinogenic amino acid catabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR008567	Beta-keto acid cleavage enzyme	Family
A, B, C, D	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.