Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and CORTISONE. Resolution 1.90 A.
External Resource: Annotation
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
A | SCOP2B Superfamily | NAD(P)-linked oxidoreductase | 8061991 | 3000288 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | NAD(P)-linked oxidoreductase | 8061991 | 3000288 | SCOP2B (2022-06-29) |
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
A | Aldo_ket_red | e3cmfA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Aldo_ket_red | ECOD (1.6) |
B | Aldo_ket_red | e3cmfB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: Aldo_ket_red | ECOD (1.6) |
Chains | Accession | Name | Description | Comments | Source |
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| PF00248 | Aldo/keto reductase family (Aldo_ket_red) | Aldo/keto reductase family | This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2]. | Domain |
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
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| 3-oxo-5-beta-steroid 4-dehydrogenase | - aldo-keto reductase (NADPH) activity
- alcohol dehydrogenase [NAD(P)+] activity
- oxidoreductase activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- oxidoreductase activity, acting on CH-OH group of donors
- catalytic activity
- alcohol dehydrogenase (NADP+) activity
- aldose reductase (NADPH) activity
- enone reductase activity
- oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
- Delta4-3-oxosteroid 5beta-reductase activity
- oxidoreductase activity, acting on the CH-CH group of donors
- binding
- organic cyclic compound binding
- steroid binding
- lipid binding
- steroid dehydrogenase activity
- monooxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- ketosteroid monooxygenase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
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Chains | Drug Target | Associated Disease |
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| Pharos: P51857 | |