3IWF

The Crystal Structure of the N-terminal domain of a RpiR Transcriptional Regulator from Staphylococcus epidermidis to 1.4A

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Homeodomain-like	8085427	3000001	SCOP2B (2022-06-29)
A	SCOP2 Family	RpiR-like	8085426	4000148	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Homeodomain-like	8085427	3000001	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	HTH_6	e3iwfB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: HTH_6	ECOD (1.6)
A	HTH_6	e3iwfA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: HTH_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01418	Helix-turn-helix domain, rpiR family (HTH_6)	Helix-turn-helix domain, rpiR family	This domain contains a helix-turn-helix motif [1]. The best characterised member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transcription regulator RpiR family	DNA binding binding organic cyclic compound binding nucleic acid binding carbohydrate derivative binding transcription regulator activity DNA-binding transcription factor activity	carbohydrate derivative metabolic process metabolic process cellular process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A, B	IPR046348	SIS domain superfamily	Homologous Superfamily
A, B	IPR035472	RpiR-like, SIS domain	Domain
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR047640	HTH-type transcriptional regulator RpiR-like	Family
A, B	IPR000281	Helix-turn-helix protein RpiR	Domain
A, B	IPR001347	SIS domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.