3JUT

Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d3jutf_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3juta_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3jutb_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3jutc_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3jutd_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3jute_	All beta proteins	beta-Trefoil	Cytokine	Fibroblast growth factors (FGF)	Acidic FGF (FGF1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Cytokine	8042239	3000648	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	FGF	e3jutF1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
A	FGF	e3jutA1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
B	FGF	e3jutB1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
C	FGF	e3jutC1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
D	FGF	e3jutD1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)
E	FGF	e3jutE1	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: FGF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
A	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
C	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
D	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
E	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00167	Fibroblast growth factor (FGF)	Fibroblast growth factor	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, c ...	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular [2]. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Heparin-binding growth factor 1	protein binding binding signaling receptor binding fibroblast growth factor receptor binding growth factor receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity Hsp70 protein binding protein-folding chaperone binding heat shock protein binding protein binding binding signaling receptor binding fibroblast growth factor receptor binding growth factor receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity Hsp70 protein binding protein-folding chaperone binding heat shock protein binding S100 protein binding cell adhesion molecule binding protein-containing complex binding integrin binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	multicellular organismal process mesonephric epithelium development kidney epithelium development nephron morphogenesis developmental growth branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis ureteric bud elongation nephron tubule development renal system development multicellular organism development ureteric bud morphogenesis tube morphogenesis branch elongation involved in ureteric bud branching multicellular organismal process mesonephric epithelium development kidney epithelium development nephron morphogenesis developmental growth branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis ureteric bud elongation nephron tubule development renal system development multicellular organism development ureteric bud morphogenesis tube morphogenesis branch elongation involved in ureteric bud branching branching involved in ureteric bud morphogenesis anatomical structure development renal tubule development animal organ morphogenesis epithelial tube morphogenesis nephron development system development nephron epithelium development developmental process ureteric bud development epithelium development axis elongation tube development mesonephros development branch elongation of an epithelium animal organ development growth morphogenesis of an epithelium tissue development developmental growth involved in morphogenesis tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium cellular developmental process cell differentiation cellular process positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process endothelial cell migration biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of cellular process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling blood vessel morphogenesis angiogenesis vasculature development circulatory system development anatomical structure formation involved in morphogenesis blood vessel development response to fibroblast growth factor cellular response to growth factor stimulus regulation of response to external stimulus endothelial cell chemotaxis to fibroblast growth factor cellular response to endogenous stimulus taxis endothelial cell chemotaxis regulation of cell chemotaxis to fibroblast growth factor cell chemotaxis chemotaxis regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of endothelial cell chemotaxis response to endogenous stimulus regulation of cellular response to growth factor stimulus response to external stimulus regulation of chemotaxis cellular response to chemical stimulus response to chemical cell chemotaxis to fibroblast growth factor response to growth factor cellular response to fibroblast growth factor stimulus regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of biosynthetic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process cellular response to heat cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus regulation of cholesterol metabolic process sterol metabolic process regulation of lipid metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process regulation of alcohol biosynthetic process positive regulation of cholesterol biosynthetic process positive regulation of steroid biosynthetic process sterol biosynthetic process regulation of sterol biosynthetic process regulation of steroid biosynthetic process regulation of cholesterol biosynthetic process organic hydroxy compound metabolic process steroid metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process steroid biosynthetic process secondary alcohol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process cholesterol biosynthetic process secondary alcohol metabolic process positive regulation of lipid biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process lipid metabolic process respiratory tube development lung development respiratory system development positive regulation of cell division cell division regulation of cell division regulation of developmental process endothelium development morphogenesis of an endothelium endothelial tube morphogenesis regulation of endothelial tube morphogenesis regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of MAP kinase activity regulation of protein serine/threonine kinase activity regulation of hepatocyte proliferation gland development liver development gland morphogenesis epithelial cell proliferation liver morphogenesis positive regulation of epithelial cell proliferation epithelial cell proliferation involved in liver morphogenesis hepatocyte proliferation hepaticobiliary system development positive regulation of hepatocyte proliferation regulation of epithelial cell proliferation cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway fibroblast growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of vasculature development positive regulation of developmental process regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process wound healing response to wounding regulation of sprouting angiogenesis positive regulation of sprouting angiogenesis sprouting angiogenesis specification of animal organ identity pattern specification process developmental induction animal organ formation regulation of animal organ morphogenesis regionalization positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular matrix external encapsulating structure membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol extracellular matrix external encapsulating structure membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR008996	Cytokine IL1/FGF	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR002209	Fibroblast growth factor family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P05230	Weight Gain leukemia ovarian cancer pulmonary fibrosis medulloblastoma osteosarcoma pituitary cancer atypical teratoid rhabdoid tumor breast carcinoma Down syndrome heart disease idiopathic interstitial pneumonia malignant mesothelioma mesothelioma primitive neuroectodermal tumor Weight Gain leukemia ovarian cancer pulmonary fibrosis medulloblastoma osteosarcoma pituitary cancer atypical teratoid rhabdoid tumor breast carcinoma Down syndrome heart disease idiopathic interstitial pneumonia malignant mesothelioma mesothelioma primitive neuroectodermal tumor benign mesothelioma coronary artery disease ductal breast carcinoma in situ invasive ductal breast carcinoma lung carcinoma myocardial ischemia ovarian neoplasm breast cancer cystic fibrosis hypotensive disorder large cell medulloblastoma malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.