4R38

LOV domain from Erythrobacter litoralis EL346 blue-light activated histidine kinase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4r38b_	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	(Erythrobacter litoralis HTCC2594 ) [TaxId: 314225 ],	SCOPe (2.08)
C	d4r38c_	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	(Erythrobacter litoralis HTCC2594 ) [TaxId: 314225 ],	SCOPe (2.08)
D	d4r38d_	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	(Erythrobacter litoralis HTCC2594 ) [TaxId: 314225 ],	SCOPe (2.08)
A	d4r38a_	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	automated matches	automated matches	(Erythrobacter litoralis HTCC2594 ) [TaxId: 314225 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Flavin-binding PAS domain	8084697	4003660	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	PYP-like sensor domain (PAS domain)	8084698	3000471	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8084698	3000471	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8084698	3000471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PYP-like sensor domain (PAS domain)	8084698	3000471	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PAS	e4r38B1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)
C	PAS	e4r38C1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)
D	PAS	e4r38D1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)
A	PAS	e4r38A1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
C	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
D	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13426	PAS domain (PAS_9)	PAS domain	This domain is found in many signalling proteins in which it functions as a sensor domain. It recognises FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Blue-light-activated histidine kinase 2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups molecular transducer activity photoreceptor activity signaling receptor activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B, C, D	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
A, B, C, D	IPR000700	PAS-associated, C-terminal	Domain
A, B, C, D	IPR005467	Histidine kinase domain	Domain
A, B, C, D	IPR000014	PAS domain	Domain
A, B, C, D	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A, B, C, D	IPR011495	Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain	Domain
A, B, C, D	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.