Crystal Structure of PGT121 Fab Bound to a complex-type sialylated N-glycan
External Resource: Annotation
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
B [auth L] | C1-set | e4fqcL3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
B [auth L] | V-set_3 | e4fqcL4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
A [auth H] | V-set_8 | e4fqcH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
A [auth H] | C1-set_1 | e4fqcH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
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B [auth L] | PGT121 mAb, anti-gp120 [HIV-1], broadly neutralizing | L-LAMBDA | Homo sapiens (human) | IGLV3-21*01, IGLJ3*02, IGLC2*01, IGLC2*02, IGLC3*04 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-1_LAMBDA | IMGT (202445-0) |
A [auth H] | PGT121 mAb, anti-gp120 [HIV-1], broadly neutralizing | VH-CH1 | Homo sapiens (human) | IGHV4-59*01, IGHV4-59*08, IGHV4-4*08, IGHJ6*03, IGHG1*03 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_LAMBDA | IMGT (202445-0) |
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
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B [auth L] | Light Chain | IGLV3 | Lambda | - | SAbDab (2024-11-15) |
A [auth H] | Heavy Chain | IGHV4 | - | - | SAbDab (2024-11-15) |