4PA0 | pdb_00004pa0

Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GFP-like	8096046	3000576	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GFP	e4pa0A1	A: beta barrels	X: GFP-like (From Topology)	H: GFP-like (From Topology)	T: GFP-like	F: GFP	ECOD (1.6)
A	Myosin_N	e4pa0A2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Myosin_N	ECOD (1.6)
A	Myosin_head,IQ_2	e4pa0A3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Myosin_head,IQ_2	ECOD (1.6)
B	GFP	e4pa0B1	A: beta barrels	X: GFP-like (From Topology)	H: GFP-like (From Topology)	T: GFP-like	F: GFP	ECOD (1.6)
B	Myosin_N	e4pa0B2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Myosin_N	ECOD (1.6)
B	Myosin_head,IQ_2	e4pa0B3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Myosin_head,IQ_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.530	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (utative)
A	1.20.58.60	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (utative)
B	1.20.58.530	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (utative)
B	1.20.58.60	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A, B	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)		Domain
A, B	PF01353	Green fluorescent protein (GFP)	Green fluorescent protein		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Myosin-7,Green fluorescent protein	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity microfilament motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity	bioluminescence metabolic process cellular process generation of precursor metabolites and energy heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process bioluminescence metabolic process cellular process generation of precursor metabolites and energy heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate muscle contraction muscle system process striated muscle contraction nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process regulation of the force of heart contraction regulation of muscle adaptation striated muscle adaptation response to stimulus transition between fast and slow fiber regulation of skeletal muscle adaptation regulation of muscle system process muscle adaptation regulation of response to stimulus skeletal muscle adaptation slow-twitch skeletal muscle fiber contraction twitch skeletal muscle contraction multicellular organismal movement musculoskeletal movement regulation of twitch skeletal muscle contraction regulation of skeletal muscle contraction regulation of slow-twitch skeletal muscle fiber contraction nervous system process neuromuscular process skeletal muscle contraction voluntary skeletal muscle contraction regulation of striated muscle contraction regulation of muscle contraction muscle filament sliding actin filament-based process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding cardiac muscle contraction developmental process heart development multicellular organism development anatomical structure development animal organ development adult heart development circulatory system development system development ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis anatomical structure morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of the force of skeletal muscle contraction regulation of skeletal muscle contraction by chemo-mechanical energy conversion muscle hypertrophy striated muscle hypertrophy cardiac muscle adaptation response to stress cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex protein-containing complex actin cytoskeleton myosin complex cytoskeleton myosin II complex muscle myosin complex myosin filament actin filament bundle actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000786	Green fluorescent protein, GFP	Family
A, B	IPR011584	Green fluorescent protein-related	Family
A, B	IPR009017	Green fluorescent protein	Homologous Superfamily
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001609	Myosin head, motor domain-like	Domain
A, B	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B	IPR002928	Myosin tail	Domain
A, B	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12883	myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy MYH7-related late-onset scapuloperoneal muscular dystrophy atrial fibrillation centronuclear myopathy coronary stenosis familial dilated cardiomyopathy heart disease LEFT VENTRICULAR NONCOMPACTION 5 arthrogryposis autosomal dominant centronuclear myopathy Charcot-Marie-Tooth disease scapuloperoneal myopathy familial hypertrophic cardiomyopathy hyaline body myopathy malignant ependymoma psoriasis X-linked centronuclear myopathy dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy myopathy autosomal recessive centronuclear myopathy myotonia congenita restrictive cardiomyopathy tubular aggregate myopathy X-linked Emery-Dreifuss muscular dystrophy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.