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Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A [auth H] V-set_8 e5fuzH2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: V-set_8 ECOD (1.6) A [auth H] C1-set_1 e5fuzH1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: C1-set_1 ECOD (1.6) B [auth L] C1-set_4 e5fuzL1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: C1-set_4 ECOD (1.6) B [auth L] V-set e5fuzL2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: V-set ECOD (1.6)
Chain Protein Name Description Organism Name Gene Allele Name(s) Domain Name(s) Receptor Type Receptor Description Provenance Source A [auth H] 645 Fab, atni-serum albumin VH-CH1 Homo sapiens (human) IGHV3-23*01, IGHV3-23D*01, IGHJ2*01, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202516-0) B [auth L] 645 Fab, atni-serum albumin L-KAPPA Homo sapiens (human) IGKV1-12*01, IGKV1D-12*01, IGKV1-12*02, IGKV1D-12*02, IGKJ4*01, IGKJ4*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202516-0)
Chain Chain Class Chain Subclass Chain Type Antigen Name(s) Provenance Source A [auth H] Heavy Chain IGHV3 - - SAbDab (2025-05-02) B [auth L] Light Chain IGKV1 Kappa - SAbDab (2025-05-02)
