5TIO
Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607
External Resource: Annotation
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth C] | Neur_chan_LBD | e5tioC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: Neur_chan_LBD | ECOD (1.6) |
A [auth C] | Neur_chan_memb | e5tioC2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: Neur_chan_memb | ECOD (1.6) |
B [auth A] | Neur_chan_LBD | e5tioA1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: Neur_chan_LBD | ECOD (1.6) |
B [auth A] | Neur_chan_memb | e5tioA2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: Neur_chan_memb | ECOD (1.6) |
C [auth B] | Neur_chan_LBD | e5tioB1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: Neur_chan_LBD | ECOD (1.6) |
C [auth B] | Neur_chan_memb | e5tioB2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: Neur_chan_memb | ECOD (1.6) |
D | Neur_chan_LBD | e5tioD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: Neur_chan_LBD | ECOD (1.6) |
D | Neur_chan_memb | e5tioD2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: Neur_chan_memb | ECOD (1.6) |
E | Neur_chan_LBD | e5tioE1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Nicotinic receptor ligand binding domain-like (From Topology) | T: Nicotinic receptor ligand binding domain-like | F: Neur_chan_LBD | ECOD (1.6) |
E | Neur_chan_memb | e5tioE2 | A: alpha bundles | X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology) | T: Neurotransmitter-gated ion-channel transmembrane pore | F: Neur_chan_memb | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth C], B [auth A], C [auth B], D, E | PF02932 | Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb) | Neurotransmitter-gated ion-channel transmembrane region | - | Family |
A [auth C], B [auth A], C [auth B], D, E | PF02931 | Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD) | Neurotransmitter-gated ion-channel ligand binding domain | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
A [auth C], B [auth A], C [auth B], D, E | O75311 | : 
Membrane Protein Annotation: PDBTM PDBTM Database Homepage
Chains | External Link | Comment |
---|---|---|
PDBTM | Annotated as membrane protein by PDBTM |
Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage
Chains | External Link | Comment |
---|---|---|
MemProtMD | Annotated as membrane protein by MemProtMD |
Membrane Protein Annotation: mpstruc mpstruc Database Homepage
Chains | Resource Link | Group | Subgroup | Protein |
---|---|---|---|---|
mpstruc | TRANSMEMBRANE PROTEINS: ALPHA-HELICAL | Cys-Loop Receptor Family | Human glycine receptor (hGlyR-¦Á3) N38Q mutant in complex with AM-3607 |