6DZM

Bundibugyo virus GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab

External Resource: Annotation

Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Filo_glycop	e6dzmA1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
E [auth B]	Filo_glycop	e6dzmB1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
I [auth C]	Filo_glycop	e6dzmC1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: Filo_glycop	ECOD (1.6)
B [auth D]	Ebola-like_HR1-HR2	e6dzmD1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
F [auth E]	Ebola-like_HR1-HR2	e6dzmE1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
J [auth F]	Ebola-like_HR1-HR2	e6dzmF1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: Ebola-like_HR1-HR2	ECOD (1.6)
C [auth H]	V-set	e6dzmH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
G [auth K]	V-set	e6dzmK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
K [auth L]	V-set	e6dzmL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
D [auth G]	V-set_12	e6dzmG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
H [auth I]	V-set_12	e6dzmI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
L [auth J]	V-set_12	e6dzmJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
C [auth H], G [auth K], K [auth L]	Fab ADI-15878	V-KAPPA	Homo sapiens (human)	IGKV1-501, IGKJ401, IGKJ4*02	V-DOMAIN V-KAPPA	RPI	VH-V-KAPPA	IMGT (202500-0)
D [auth G], H [auth I], L [auth J]	Fab ADI-15878	VH	Homo sapiens (human)	IGHV3-2304, IGHJ401, IGHJ402, IGHJ403	V-DOMAIN VH	RPI	VH-V-KAPPA	IMGT (202500-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C [auth H], G [auth K], K [auth L]	Light Chain	IGKV1	Kappa	bundibugyo virus gp2 \| bundibugyo virus gp1	SAbDab (2025-01-10)
D [auth G], H [auth I], L [auth J]	Heavy Chain	IGHV3	-	bundibugyo virus gp2 \| bundibugyo virus gp1	SAbDab (2025-01-10)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth B], I [auth C]	PF01611	Filovirus glycoprotein (Filo_glycop)	Filovirus glycoprotein	-	Family
B [auth D], F [auth E], J [auth F]	PF22307	Envelope glycoprotein GP2-like, HR1-HR2 (Ebola-like_HR1-HR2)	Envelope glycoprotein GP2-like, HR1-HR2	This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel ...	This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel orientation). This domain may have been acquired via horizontal transfer from retroviruses.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth B], I [auth C]	Bundibugyo virus GP1	-	-	virion component viral membrane viral envelope cellular anatomical structure membrane extracellular region
B [auth D], F [auth E], J [auth F]	Bundibugyo virus GP2	-	-	virion component viral membrane viral envelope cellular anatomical structure membrane extracellular region
C [auth H], G [auth K], K [auth L]	Antibody ADI-15878 Fab, light chain	-	-	-
D [auth G], H [auth I], L [auth J]	Antibody ADI-15878 Fab, heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth B], I [auth C]	IPR014625	Filoviruses glycoprotein	Family
A, E [auth B], I [auth C]	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
A, E [auth B], I [auth C]	IPR054584	Envelope glycoprotein GP2-like, HR1-HR2	Domain
B [auth D], F [auth E], J [auth F]	IPR014625	Filoviruses glycoprotein	Family
B [auth D], F [auth E], J [auth F]	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
B [auth D], F [auth E], J [auth F]	IPR054584	Envelope glycoprotein GP2-like, HR1-HR2	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.