6KE5

Structure of CavAb in complex with Diltiazem and Amlodipine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6ke5b_	Membrane and cell surface proteins and peptides	Gated ion channels	Voltage-gated ion channels	Voltage-gated Na/Ca cation channels	NavAb sodium channel	(Aliarcobacter butzleri RM4018 ) [TaxId: 367737 ],	SCOPe (2.08)
C	d6ke5c_	Membrane and cell surface proteins and peptides	Gated ion channels	Voltage-gated ion channels	Voltage-gated Na/Ca cation channels	NavAb sodium channel	(Aliarcobacter butzleri RM4018 ) [TaxId: 367737 ],	SCOPe (2.08)
A	d6ke5a_	Membrane and cell surface proteins and peptides	Gated ion channels	Voltage-gated ion channels	Voltage-gated Na/Ca cation channels	NavAb sodium channel	(Aliarcobacter butzleri RM4018 ) [TaxId: 367737 ],	SCOPe (2.08)
D	d6ke5d_	Membrane and cell surface proteins and peptides	Gated ion channels	Voltage-gated ion channels	Voltage-gated Na/Ca cation channels	NavAb sodium channel	(Aliarcobacter butzleri RM4018 ) [TaxId: 367737 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ion_trans	e6ke5B1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
C	Ion_trans	e6ke5C1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
A	Ion_trans	e6ke5A1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)
D	Ion_trans	e6ke5D1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08016	Polycystin cation channel (PKD_channel)	Polycystin cation channel	-	Family
A, B, C, D	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Ion transport protein	monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	-	protein-containing complex sodium channel complex voltage-gated sodium channel complex plasma membrane protein complex membrane plasma membrane membrane protein complex cation channel complex transporter complex cell periphery cellular anatomical structure transmembrane transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR043203	Voltage-gated cation channel calcium and sodium	Family
A, B, C, D	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Voltage-gated calcium and sodium channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.