Annotations: 6MRD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth O]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)
C [auth U]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)
D [auth T]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)
E [auth S]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)
F [auth R]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)
G [auth Q]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)
H [auth P]	SCOP2B Superfamily	GroES-like	8074768	3000002	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cpn60_TCP1_1st	e6mrdA3	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
A	Cpn60_TCP1_2nd_2	e6mrdA1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
A	Cpn60_TCP1_3rd	e6mrdA2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
I [auth G]	Cpn60_TCP1_1st	e6mrdG2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
I [auth G]	Cpn60_TCP1_2nd_2	e6mrdG1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
I [auth G]	Cpn60_TCP1_3rd	e6mrdG3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
J [auth F]	Cpn60_TCP1_1st	e6mrdF2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
J [auth F]	Cpn60_TCP1_2nd_2	e6mrdF3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
J [auth F]	Cpn60_TCP1_3rd	e6mrdF1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
K [auth E]	Cpn60_TCP1_1st	e6mrdE2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
K [auth E]	Cpn60_TCP1_2nd_2	e6mrdE1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
K [auth E]	Cpn60_TCP1_3rd	e6mrdE3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
L [auth D]	Cpn60_TCP1_1st	e6mrdD2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
L [auth D]	Cpn60_TCP1_2nd_2	e6mrdD3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
L [auth D]	Cpn60_TCP1_3rd	e6mrdD1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
M [auth C]	Cpn60_TCP1_1st	e6mrdC2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
M [auth C]	Cpn60_TCP1_2nd_2	e6mrdC1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
M [auth C]	Cpn60_TCP1_3rd	e6mrdC3	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
N [auth B]	Cpn60_TCP1_1st	e6mrdB2	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
N [auth B]	Cpn60_TCP1_2nd_2	e6mrdB3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
N [auth B]	Cpn60_TCP1_3rd	e6mrdB1	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
B [auth O]	Cpn10	e6mrdO1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
C [auth U]	Cpn10	e6mrdU1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
D [auth T]	Cpn10	e6mrdT1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
E [auth S]	Cpn10	e6mrdS1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
F [auth R]	Cpn10	e6mrdR1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
G [auth Q]	Cpn10	e6mrdQ1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
H [auth P]	Cpn10	e6mrdP1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
A	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
I [auth G]	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
I [auth G]	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
J [auth F]	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
J [auth F]	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
K [auth E]	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
K [auth E]	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
L [auth D]	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
L [auth D]	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
M [auth C]	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
M [auth C]	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
N [auth B]	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (utative)
N [auth B]	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (utative)
B [auth O]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)
C [auth U]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)
D [auth T]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)
E [auth S]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)
F [auth R]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)
G [auth Q]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)
H [auth P]	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	PF00118	TCP-1/cpn60 chaperonin family (Cpn60_TCP1)	TCP-1/cpn60 chaperonin family	-	Family
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	PF00166	Chaperonin 10 Kd subunit (Cpn10)	Chaperonin 10 Kd subunit	This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	60 kDa heat shock protein, mitochondrial	RNA binding double-stranded RNA binding binding nucleic acid binding apolipoprotein binding protein binding apolipoprotein A-I binding cysteine-type endopeptidase activator activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein molecular function activator activity hydrolase activity RNA binding double-stranded RNA binding binding nucleic acid binding apolipoprotein binding protein binding apolipoprotein A-I binding cysteine-type endopeptidase activator activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein molecular function activator activity hydrolase activity peptidase activator activity endopeptidase regulator activity cysteine-type peptidase activity endopeptidase activator activity enzyme activator activity molecular function regulator activity cysteine-type endopeptidase activity catalytic activity endopeptidase activity protein-folding chaperone binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding lipoprotein particle binding protein-containing complex binding protein-lipid complex binding high-density lipoprotein particle binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding p53 binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding DNA replication origin binding lipid binding lipopolysaccharide binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity unfolded protein binding isomerase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides single-stranded DNA binding	protein refolding primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of protein stability biological regulation regulation of biological quality protein refolding primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus toll-like receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway MyD88-dependent toll-like receptor signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response response to abiotic stimulus response to cold response to temperature stimulus response to topologically incorrect protein response to unfolded protein multicellular organismal process B cell activation cell activation lymphocyte activation leukocyte activation positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis apoptotic process programmed cell death positive regulation of cellular process interleukin-10 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of interleukin-10 production regulation of biosynthetic process regulation of macromolecule metabolic process positive regulation of interleukin-10 production regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process 'de novo' protein folding adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity B cell activation involved in immune response cell activation involved in immune response nucleobase-containing compound metabolic process multicellular organism development anatomical structure development leukocyte mediated immunity somatic diversification of immune receptors somatic recombination of immunoglobulin genes involved in immune response system development developmental process DNA recombination DNA metabolic process immune effector process somatic diversification of immunoglobulins B cell mediated immunity isotype switching immune system development immunoglobulin production immunoglobulin production involved in immunoglobulin-mediated immune response somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments leukocyte activation involved in immune response lymphocyte activation involved in immune response production of molecular mediator of immune response immunoglobulin mediated immune response adaptive immune response nucleic acid metabolic process isotype switching to IgG isotypes somatic diversification of immune receptors via germline recombination within a single locus interferon-alpha production regulation of interferon-alpha production positive regulation of type I interferon production type I interferon production positive regulation of interferon-alpha production regulation of type I interferon production regulation of macrophage activation positive regulation of macrophage activation regulation of leukocyte activation regulation of cell activation myeloid leukocyte activation macrophage activation positive regulation of cell activation positive regulation of leukocyte activation cellular component organization organelle organization apoptotic mitochondrial changes cellular component organization or biogenesis mitochondrion organization cellular component biogenesis cellular component assembly chaperone-mediated protein complex assembly protein-containing complex organization protein-containing complex assembly negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production mitochondrial unfolded protein response cellular response to topologically incorrect protein cellular response to stress cellular response to unfolded protein regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production biological process involved in interaction with symbiont biological process involved in symbiotic interaction negative regulation of execution phase of apoptosis T cell activation cell population proliferation B cell proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation regulation of immune effector process T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains immune response to tumor cell positive regulation of lymphocyte mediated immunity regulation of response to tumor cell T cell mediated immune response to tumor cell regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated immune response to tumor cell positive regulation of immune effector process positive regulation of adaptive immune response regulation of T cell mediated immunity response to tumor cell positive regulation of immune response to tumor cell regulation of adaptive immune response regulation of immune response to tumor cell positive regulation of T cell mediated immune response to tumor cell regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity positive regulation of response to tumor cell protein localization establishment of protein localization cellular localization nitrogen compound transport protein transmembrane import into intracellular organelle transport protein targeting localization protein transmembrane transport cellular macromolecule localization mitochondrial transport protein import into mitochondrial intermembrane space establishment of localization mitochondrial transmembrane transport transmembrane transport establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of leukocyte cell-cell adhesion regulation of lymphocyte activation response to peptide response to interleukin-7 response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-7 regulation of type II interferon production type II interferon production positive regulation of type II interferon production	cellular anatomical structure clathrin-coated pit membrane endomembrane system extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cellular anatomical structure clathrin-coated pit membrane endomembrane system extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle secretory granule secretory vesicle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection coated vesicle cell periphery plasma membrane sperm plasma membrane mitochondrion mitochondrial membrane organelle inner membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cell surface lipopolysaccharide receptor complex protein-containing complex membrane protein complex receptor complex migrasome early endosome endosome membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	10 kDa heat shock protein, mitochondrial	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding protein folding chaperone RNA binding nucleic acid binding cation binding metal ion binding protein-folding chaperone binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell death developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell death intracellular signal transduction cell communication apoptotic signaling pathway signal transduction apoptotic process intrinsic apoptotic signaling pathway programmed cell death protein folding biosynthetic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation chaperone cofactor-dependent protein refolding chaperone-mediated protein folding 'de novo' protein folding 'de novo' post-translational protein folding response to topologically incorrect protein response to stress response to unfolded protein	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	IPR027413	GroEL-like equatorial domain superfamily	Homologous Superfamily
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	IPR027410	TCP-1-like chaperonin intermediate domain superfamily	Homologous Superfamily
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	IPR018370	Chaperonin Cpn60, conserved site	Conserved Site
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	IPR001844	Chaperonin Cpn60/GroEL	Family
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	IPR027409	GroEL-like apical domain superfamily	Homologous Superfamily
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family	Family
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	IPR018369	Chaperonin GroES, conserved site	Conserved Site
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	IPR011032	GroES-like superfamily	Homologous Superfamily
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	IPR037124	GroES chaperonin superfamily	Homologous Superfamily
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	IPR020818	GroES chaperonin family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, I [auth G], J [auth F], K [auth E], L [auth D], A, I [auth G], J [auth F], K [auth E], L [auth D], M [auth C], N [auth B]	Pharos: P10809	hereditary spastic paraplegia 13 hypomyelinating leukodystrophy 4 hypertrophic cardiomyopathy leukodystrophy cardiomyopathy renal cell carcinoma tubular adenocarcinoma granular cell carcinoma acute coronary syndrome chromophobe renal cell carcinoma adenocarcinoma papillary renal cell carcinoma sarcomatoid renal cell carcinoma Endotoxemia tuberculosis hereditary spastic paraplegia 13 hypomyelinating leukodystrophy 4 hypertrophic cardiomyopathy leukodystrophy cardiomyopathy renal cell carcinoma tubular adenocarcinoma granular cell carcinoma acute coronary syndrome chromophobe renal cell carcinoma adenocarcinoma papillary renal cell carcinoma sarcomatoid renal cell carcinoma Endotoxemia tuberculosis hereditary spastic paraplegia HIV infectious disease middle cerebral artery infarction collecting duct carcinoma bipolar disorder oligodendroglioma Pelizaeus-Merzbacher disease gastric cancer hereditary diffuse gastric adenocarcinoma allergic rhinitis clear cell renal carcinoma renal carcinoma cribriform carcinoma gastric neoplasm intellectual disability malignant ependymoma autism spectrum disorder neurodegenerative disease paraplegia cribriform carcinoma of breast
B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], B [auth O], C [auth U], D [auth T], E [auth S], F [auth R], G [auth Q], H [auth P]	Pharos: P61604	cardiomyopathy allergic rhinitis Cardiomyopathies, Primary autism spectrum disorder bipolar disorder